A systematic review and meta-analysis of geographic differences in comorbidities and associated severity and mortality among individuals with COVID-19
Abstract Several comorbidities have been shown to be associated with coronavirus disease 2019 (COVID-19) related severity and mortality. However, considerable variation in the prevalence estimates of comorbidities and their effects on COVID-19 morbidity and mortality have been observed in prior stud...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2021-04-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-021-88130-w |
| _version_ | 1818694527618121728 |
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| author | Bhaskar Thakur Pallavi Dubey Joseph Benitez Joshua P. Torres Sireesha Reddy Navkiran Shokar Koko Aung Debabrata Mukherjee Alok Kumar Dwivedi |
| author_facet | Bhaskar Thakur Pallavi Dubey Joseph Benitez Joshua P. Torres Sireesha Reddy Navkiran Shokar Koko Aung Debabrata Mukherjee Alok Kumar Dwivedi |
| author_sort | Bhaskar Thakur |
| collection | DOAJ |
| description | Abstract Several comorbidities have been shown to be associated with coronavirus disease 2019 (COVID-19) related severity and mortality. However, considerable variation in the prevalence estimates of comorbidities and their effects on COVID-19 morbidity and mortality have been observed in prior studies. This systematic review and meta-analysis aimed to determine geographical, age, and gender related differences in the prevalence of comorbidities and associated severity and mortality rates among COVID-19 patients. We conducted a search using PubMed, Scopus, and EMBASE to include all COVID-19 studies published between January 1st, 2020 to July 24th, 2020 reporting comorbidities with severity or mortality. We included studies reporting the confirmed diagnosis of COVID-19 on human patients that also provided information on comorbidities or disease outcomes. We used DerSimonian and Laird random effects method for calculating estimates. Of 120 studies with 125,446 patients, the most prevalent comorbidity was hypertension (32%), obesity (25%), diabetes (18%), and cardiovascular disease (16%) while chronic kidney or other renal diseases (51%, 44%), cerebrovascular accident (43%, 44%), and cardiovascular disease (44%, 40%) patients had more COVID-19 severity and mortality respectively. Considerable variation in the prevalence of comorbidities and associated disease severity and mortality in different geographic regions was observed. The highest mortality was observed in studies with Latin American and European patients with any medical condition, mostly older adults (≥ 65 years), and predominantly male patients. Although the US studies observed the highest prevalence of comorbidities in COVID-19 patients, the severity of COVID-19 among each comorbid condition was highest in Asian studies whereas the mortality was highest in the European and Latin American countries. Risk stratification and effective control strategies for the COVID-19 should be done according to comorbidities, age, and gender differences specific to geographical location. |
| first_indexed | 2024-12-17T13:31:00Z |
| format | Article |
| id | doaj.art-76b73e51a68e407d854a30dbcd84dc49 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-17T13:31:00Z |
| publishDate | 2021-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-76b73e51a68e407d854a30dbcd84dc492022-12-21T21:46:35ZengNature PortfolioScientific Reports2045-23222021-04-0111111310.1038/s41598-021-88130-wA systematic review and meta-analysis of geographic differences in comorbidities and associated severity and mortality among individuals with COVID-19Bhaskar Thakur0Pallavi Dubey1Joseph Benitez2Joshua P. Torres3Sireesha Reddy4Navkiran Shokar5Koko Aung6Debabrata Mukherjee7Alok Kumar Dwivedi8Division of Biostatistics and Epidemiology, Department of Molecular and Translational Medicine, Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center El PasoDepartment of Obstetrics and Gynecology, Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center El PasoGraduate School of Biomedical Sciences, Texas Tech University Health Sciences Center El PasoGraduate School of Biomedical Sciences, Texas Tech University Health Sciences Center El PasoDepartment of Obstetrics and Gynecology, Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center El PasoDepartment of Family and Community Medicine, Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center El PasoDepartment of Internal Medicine, Paul L. Foster School of Medicine, Texas Tech University Health Science Center El PasoDepartment of Internal Medicine, Paul L. Foster School of Medicine, Texas Tech University Health Science Center El PasoDivision of Biostatistics and Epidemiology, Department of Molecular and Translational Medicine, Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center El PasoAbstract Several comorbidities have been shown to be associated with coronavirus disease 2019 (COVID-19) related severity and mortality. However, considerable variation in the prevalence estimates of comorbidities and their effects on COVID-19 morbidity and mortality have been observed in prior studies. This systematic review and meta-analysis aimed to determine geographical, age, and gender related differences in the prevalence of comorbidities and associated severity and mortality rates among COVID-19 patients. We conducted a search using PubMed, Scopus, and EMBASE to include all COVID-19 studies published between January 1st, 2020 to July 24th, 2020 reporting comorbidities with severity or mortality. We included studies reporting the confirmed diagnosis of COVID-19 on human patients that also provided information on comorbidities or disease outcomes. We used DerSimonian and Laird random effects method for calculating estimates. Of 120 studies with 125,446 patients, the most prevalent comorbidity was hypertension (32%), obesity (25%), diabetes (18%), and cardiovascular disease (16%) while chronic kidney or other renal diseases (51%, 44%), cerebrovascular accident (43%, 44%), and cardiovascular disease (44%, 40%) patients had more COVID-19 severity and mortality respectively. Considerable variation in the prevalence of comorbidities and associated disease severity and mortality in different geographic regions was observed. The highest mortality was observed in studies with Latin American and European patients with any medical condition, mostly older adults (≥ 65 years), and predominantly male patients. Although the US studies observed the highest prevalence of comorbidities in COVID-19 patients, the severity of COVID-19 among each comorbid condition was highest in Asian studies whereas the mortality was highest in the European and Latin American countries. Risk stratification and effective control strategies for the COVID-19 should be done according to comorbidities, age, and gender differences specific to geographical location.https://doi.org/10.1038/s41598-021-88130-w |
| spellingShingle | Bhaskar Thakur Pallavi Dubey Joseph Benitez Joshua P. Torres Sireesha Reddy Navkiran Shokar Koko Aung Debabrata Mukherjee Alok Kumar Dwivedi A systematic review and meta-analysis of geographic differences in comorbidities and associated severity and mortality among individuals with COVID-19 Scientific Reports |
| title | A systematic review and meta-analysis of geographic differences in comorbidities and associated severity and mortality among individuals with COVID-19 |
| title_full | A systematic review and meta-analysis of geographic differences in comorbidities and associated severity and mortality among individuals with COVID-19 |
| title_fullStr | A systematic review and meta-analysis of geographic differences in comorbidities and associated severity and mortality among individuals with COVID-19 |
| title_full_unstemmed | A systematic review and meta-analysis of geographic differences in comorbidities and associated severity and mortality among individuals with COVID-19 |
| title_short | A systematic review and meta-analysis of geographic differences in comorbidities and associated severity and mortality among individuals with COVID-19 |
| title_sort | systematic review and meta analysis of geographic differences in comorbidities and associated severity and mortality among individuals with covid 19 |
| url | https://doi.org/10.1038/s41598-021-88130-w |
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