Association between Geriatric Nutrition Risk Index and Skeletal Muscle Mass Index with Bone Mineral Density in Post-Menopausal Women Who Have Undergone Total Thyroidectomy
Background: Osteoporosis is highly prevalent in postmenopausal women and may result in fractures and disabilities. Total thyroidectomy has also been associated with loss of bone mass. The aim of this cross-sectional study was to evaluate associations among nutritional status, skeletal muscle index a...
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| Format: | Article |
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MDPI AG
2020-06-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/12/6/1683 |
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| author | Tai-Hua Chiu Szu-Chia Chen Hui-Chen Yu Jui-Sheng Hsu Ming-Chen Shih He-Jiun Jiang Wei-Hao Hsu Mei-Yueh Lee |
| author_facet | Tai-Hua Chiu Szu-Chia Chen Hui-Chen Yu Jui-Sheng Hsu Ming-Chen Shih He-Jiun Jiang Wei-Hao Hsu Mei-Yueh Lee |
| author_sort | Tai-Hua Chiu |
| collection | DOAJ |
| description | Background: Osteoporosis is highly prevalent in postmenopausal women and may result in fractures and disabilities. Total thyroidectomy has also been associated with loss of bone mass. The aim of this cross-sectional study was to evaluate associations among nutritional status, skeletal muscle index and markers of bone turnover to bone mineral density in postmenopausal women who had undergone total thyroidectomy. Methods: Fifty postmenopausal women who had undergone total thyroidectomy were included. Body composition was measured using dual-energy X-ray absorptiometry (DXA). The Geriatric Nutritional Risk Index (GNRI) was calculated using baseline body weight and serum albumin level. Skeletal muscle mass index was calculated as the appendicular skeletal muscle mass (ASM) divided by the height squared and assessed using DXA. Results. Multivariate stepwise linear regression analysis showed that a low GNRI was significantly associated with low lumbar spine bone mineral density (BMD) and T-score, and that a low ASM/height<sup>2</sup> was significantly associated with low femoral neck BMD and T-score. A low vitamin D level was significantly associated with low femoral neck BMD and T-score and low total hip BMD and T-score. A high bone alkaline phosphatase (ALP) level was significantly associated with low femoral neck T-score and low total hip BMD and T-score. A low insulin-like growth factor-1 (IGF-1) was significantly associated with low total hip BMD and T-score. Conclusion: In the postmenopausal women who had undergone total thyroidectomy in this study, BMD was positively associated with GNRI, skeletal muscle mass index, and levels of vitamin D and serum IGF-1, and inversely associated with bone ALP level. Nutritional status, skeletal muscle mass index and bone turnover biomarkers can be used to early identify patients with a high risk of osteoporosis in this high-risk group. |
| first_indexed | 2024-03-10T19:21:51Z |
| format | Article |
| id | doaj.art-76b8a7f5383245fcbd744038e650cf74 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T19:21:51Z |
| publishDate | 2020-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-76b8a7f5383245fcbd744038e650cf742023-11-20T02:55:05ZengMDPI AGNutrients2072-66432020-06-01126168310.3390/nu12061683Association between Geriatric Nutrition Risk Index and Skeletal Muscle Mass Index with Bone Mineral Density in Post-Menopausal Women Who Have Undergone Total ThyroidectomyTai-Hua Chiu0Szu-Chia Chen1Hui-Chen Yu2Jui-Sheng Hsu3Ming-Chen Shih4He-Jiun Jiang5Wei-Hao Hsu6Mei-Yueh Lee7Department of General Medicine, Kaohsiung Medical University Hospital, Kaohsiung 807, TaiwanDivision of Nephrology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 807, TaiwanDepartment of Medical Imaging, Kaohsiung Medical University Hospital, Kaohsiung 807, TaiwanDepartment of Medical Imaging, Kaohsiung Medical University Hospital, Kaohsiung 807, TaiwanDepartment of Medical Imaging, Kaohsiung Medical University Hospital, Kaohsiung 807, TaiwanDivision of Endocrinology and Metabolism, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 807, TaiwanDepartment of Internal Medicine, Kaohsiung Municipal Siaogang Hospital, Kaohsiung Medical University, Kaohsiung 812, TaiwanFaculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, TaiwanBackground: Osteoporosis is highly prevalent in postmenopausal women and may result in fractures and disabilities. Total thyroidectomy has also been associated with loss of bone mass. The aim of this cross-sectional study was to evaluate associations among nutritional status, skeletal muscle index and markers of bone turnover to bone mineral density in postmenopausal women who had undergone total thyroidectomy. Methods: Fifty postmenopausal women who had undergone total thyroidectomy were included. Body composition was measured using dual-energy X-ray absorptiometry (DXA). The Geriatric Nutritional Risk Index (GNRI) was calculated using baseline body weight and serum albumin level. Skeletal muscle mass index was calculated as the appendicular skeletal muscle mass (ASM) divided by the height squared and assessed using DXA. Results. Multivariate stepwise linear regression analysis showed that a low GNRI was significantly associated with low lumbar spine bone mineral density (BMD) and T-score, and that a low ASM/height<sup>2</sup> was significantly associated with low femoral neck BMD and T-score. A low vitamin D level was significantly associated with low femoral neck BMD and T-score and low total hip BMD and T-score. A high bone alkaline phosphatase (ALP) level was significantly associated with low femoral neck T-score and low total hip BMD and T-score. A low insulin-like growth factor-1 (IGF-1) was significantly associated with low total hip BMD and T-score. Conclusion: In the postmenopausal women who had undergone total thyroidectomy in this study, BMD was positively associated with GNRI, skeletal muscle mass index, and levels of vitamin D and serum IGF-1, and inversely associated with bone ALP level. Nutritional status, skeletal muscle mass index and bone turnover biomarkers can be used to early identify patients with a high risk of osteoporosis in this high-risk group.https://www.mdpi.com/2072-6643/12/6/1683menopausal womentotal thyroidectomygeriatric nutritional risk indexbone mineral densityappendicular skeletal muscle mass |
| spellingShingle | Tai-Hua Chiu Szu-Chia Chen Hui-Chen Yu Jui-Sheng Hsu Ming-Chen Shih He-Jiun Jiang Wei-Hao Hsu Mei-Yueh Lee Association between Geriatric Nutrition Risk Index and Skeletal Muscle Mass Index with Bone Mineral Density in Post-Menopausal Women Who Have Undergone Total Thyroidectomy Nutrients menopausal women total thyroidectomy geriatric nutritional risk index bone mineral density appendicular skeletal muscle mass |
| title | Association between Geriatric Nutrition Risk Index and Skeletal Muscle Mass Index with Bone Mineral Density in Post-Menopausal Women Who Have Undergone Total Thyroidectomy |
| title_full | Association between Geriatric Nutrition Risk Index and Skeletal Muscle Mass Index with Bone Mineral Density in Post-Menopausal Women Who Have Undergone Total Thyroidectomy |
| title_fullStr | Association between Geriatric Nutrition Risk Index and Skeletal Muscle Mass Index with Bone Mineral Density in Post-Menopausal Women Who Have Undergone Total Thyroidectomy |
| title_full_unstemmed | Association between Geriatric Nutrition Risk Index and Skeletal Muscle Mass Index with Bone Mineral Density in Post-Menopausal Women Who Have Undergone Total Thyroidectomy |
| title_short | Association between Geriatric Nutrition Risk Index and Skeletal Muscle Mass Index with Bone Mineral Density in Post-Menopausal Women Who Have Undergone Total Thyroidectomy |
| title_sort | association between geriatric nutrition risk index and skeletal muscle mass index with bone mineral density in post menopausal women who have undergone total thyroidectomy |
| topic | menopausal women total thyroidectomy geriatric nutritional risk index bone mineral density appendicular skeletal muscle mass |
| url | https://www.mdpi.com/2072-6643/12/6/1683 |
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