Oncolytic reprogramming of tumor microenvironment shapes CD4 T-cell memory via the IL6ra-Bcl6 axis for targeted control of glioblastoma

Oncolytic reprogramming of tumor microenvironment shapes CD4 T-cell memory via the IL6ra-Bcl6 axis for targeted control of glioblastoma

Abstract Oncolytic viruses (OVs) emerge as a promising cancer immunotherapy. However, the temporal impact on tumor cells and the tumor microenvironment, and the nature of anti-tumor immunity post-therapy remain largely unclear. Here we report that CD4+ T cells are required for durable tumor control...

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Podrobná bibliografie
Hlavní autoři: Jeffrey M. Grimes, Sadashib Ghosh, Shamza Manzoor, Li X. Li, Monica M. Moran, Jennifer C. Clements, Sherrie D. Alexander, James M. Markert, Jianmei W. Leavenworth
Médium: Článek
Jazyk:English
Vydáno: Nature Portfolio 2025-01-01
Edice:Nature Communications
On-line přístup:https://doi.org/10.1038/s41467-024-55455-9

Internet

https://doi.org/10.1038/s41467-024-55455-9

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