Mice deficient in ER protein seipin have reduced adrenal cholesteryl ester lipid droplet formation and utilization

Mice deficient in ER protein seipin have reduced adrenal cholesteryl ester lipid droplet formation and utilization

Cholesteryl ester (CE)-rich lipid droplets (LDs) accumulate in steroidogenic tissues under physiological conditions and constitute an important source of cholesterol as the precursor for the synthesis of all steroid hormones. The mechanisms specifically involved in CE-rich LD formation have not been...

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Bibliographic Details
Main Authors: Wen-Jun Shen, Yuan Cortez, Amar Singh, Weiqin Chen, Salman Azhar, Fredric B. Kraemer
Format: Article
Language:English
Published: Elsevier 2022-12-01
Series:Journal of Lipid Research
Subjects:
seipin deficiency
lipid droplet maturation
cholesterol
steroidogenesis
adrenal
testis
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227522001420

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