Understanding flow chemistry for the production of active pharmaceutical ingredients
Summary: Multi-step organic syntheses of various drugs, active pharmaceutical ingredients, and other pharmaceutically and agriculturally important compounds have already been reported using flow synthesis. Compared to batch, hazardous and reactive reagents can be handled safely in flow. This review...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-03-01
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| Series: | iScience |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004222001626 |
| _version_ | 1819279328865681408 |
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| author | Anand S. Burange Sameh M. Osman Rafael Luque |
| author_facet | Anand S. Burange Sameh M. Osman Rafael Luque |
| author_sort | Anand S. Burange |
| collection | DOAJ |
| description | Summary: Multi-step organic syntheses of various drugs, active pharmaceutical ingredients, and other pharmaceutically and agriculturally important compounds have already been reported using flow synthesis. Compared to batch, hazardous and reactive reagents can be handled safely in flow. This review discusses the pros and cons of flow chemistry in today’s scenario and recent developments in flow devices. The review majorly emphasizes on the recent developments in the flow synthesis of pharmaceutically important products in last five years including flibanserin, imatinib, buclizine, cinnarizine, cyclizine, meclizine, ribociclib, celecoxib, SC-560 and mavacoxib, efavirenz, fluconazole, melitracen HCl, rasagiline, tamsulosin, valsartan, and hydroxychloroquine. Critical steps and new development in the flow synthesis of selected compounds are also discussed. |
| first_indexed | 2024-12-24T00:26:10Z |
| format | Article |
| id | doaj.art-76bd78c921524b0daac0d3a78d16f963 |
| institution | Directory Open Access Journal |
| issn | 2589-0042 |
| language | English |
| last_indexed | 2024-12-24T00:26:10Z |
| publishDate | 2022-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj.art-76bd78c921524b0daac0d3a78d16f9632022-12-21T17:24:26ZengElsevieriScience2589-00422022-03-01253103892Understanding flow chemistry for the production of active pharmaceutical ingredientsAnand S. Burange0Sameh M. Osman1Rafael Luque2Department of Chemistry, Wilson College, Chowpatty, Mumbai 400007, India; Corresponding authorChemistry Department, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi ArabiaDepartamento de Quimica Organica, Universidad de Cordoba, Edificio Marie Curie (C-3), Ctra Nnal IV-A, Km 396, E14014 Cordoba, Spain; Peoples Friendship University of Russia (RUDN University), 6 Miklukho Maklaya str., 107198 Moscow, Russian Federation; Corresponding authorSummary: Multi-step organic syntheses of various drugs, active pharmaceutical ingredients, and other pharmaceutically and agriculturally important compounds have already been reported using flow synthesis. Compared to batch, hazardous and reactive reagents can be handled safely in flow. This review discusses the pros and cons of flow chemistry in today’s scenario and recent developments in flow devices. The review majorly emphasizes on the recent developments in the flow synthesis of pharmaceutically important products in last five years including flibanserin, imatinib, buclizine, cinnarizine, cyclizine, meclizine, ribociclib, celecoxib, SC-560 and mavacoxib, efavirenz, fluconazole, melitracen HCl, rasagiline, tamsulosin, valsartan, and hydroxychloroquine. Critical steps and new development in the flow synthesis of selected compounds are also discussed.http://www.sciencedirect.com/science/article/pii/S2589004222001626ChemistryChemical engineeringOrganic chemistryGreen chemistry |
| spellingShingle | Anand S. Burange Sameh M. Osman Rafael Luque Understanding flow chemistry for the production of active pharmaceutical ingredients iScience Chemistry Chemical engineering Organic chemistry Green chemistry |
| title | Understanding flow chemistry for the production of active pharmaceutical ingredients |
| title_full | Understanding flow chemistry for the production of active pharmaceutical ingredients |
| title_fullStr | Understanding flow chemistry for the production of active pharmaceutical ingredients |
| title_full_unstemmed | Understanding flow chemistry for the production of active pharmaceutical ingredients |
| title_short | Understanding flow chemistry for the production of active pharmaceutical ingredients |
| title_sort | understanding flow chemistry for the production of active pharmaceutical ingredients |
| topic | Chemistry Chemical engineering Organic chemistry Green chemistry |
| url | http://www.sciencedirect.com/science/article/pii/S2589004222001626 |
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