Effect of fish oil on monoepoxides derived from fatty acids during cardiac surgery1[S]
Our objective was to assess the dynamics of monoepoxides derived from polyunsaturated fatty acids (MEFAs), and their response to n-3 PUFA supplementation, in the setting of acute tissue injury and inflammation (cardiac surgery) in humans. Patients (479) undergoing cardiac surgery in three countries...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2016-03-01
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| Series: | Journal of Lipid Research |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0022227520354481 |
| _version_ | 1818690640741924864 |
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| author | Emmanuel Akintoye JasonH.Y. Wu Tao Hou Xiaoling Song Jun Yang Bruce Hammock Dariush Mozaffarian |
| author_facet | Emmanuel Akintoye JasonH.Y. Wu Tao Hou Xiaoling Song Jun Yang Bruce Hammock Dariush Mozaffarian |
| author_sort | Emmanuel Akintoye |
| collection | DOAJ |
| description | Our objective was to assess the dynamics of monoepoxides derived from polyunsaturated fatty acids (MEFAs), and their response to n-3 PUFA supplementation, in the setting of acute tissue injury and inflammation (cardiac surgery) in humans. Patients (479) undergoing cardiac surgery in three countries were randomized to perioperative fish oil (EPA + DHA; 8–10 g over 2–5 days preoperatively, then 2 g/day postoperatively) or placebo (olive oil). Plasma MEFAs derived from n-3 and n-6 PUFAs were measured 2 days postoperatively. Based on serial measures in a subset of the placebo group, levels of all MEFAs declined substantially following surgery (at postoperative day 2), with declines ranging from 37% to 63% (P < 0.05 each). Compared with placebo at postoperative day 2, levels of EPA- and DHA-derived MEFAs were 40% and 18% higher, respectively (P ≤ 0.004). The n-3 PUFA supplementation did not significantly alter the decline in n-6 PUFA-derived MEFAs. Both enrollment level and changes in plasma phospholipid EPA and DHA were associated with their respective MEFAs at postoperative day 2 (P < 0.001). Under the acute stress of cardiac surgery, n-3 PUFA supplementation significantly ameliorated the reduction in postoperative n-3 MEFAs, but not n-6 MEFAs, and the degree of increase in n-3 MEFAs related positively to the circulating level of their n-3 PUFA precursors. |
| first_indexed | 2024-12-17T12:29:13Z |
| format | Article |
| id | doaj.art-76beffdcb23d40e0a3e0869ec3692cf9 |
| institution | Directory Open Access Journal |
| issn | 0022-2275 |
| language | English |
| last_indexed | 2024-12-17T12:29:13Z |
| publishDate | 2016-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Lipid Research |
| spelling | doaj.art-76beffdcb23d40e0a3e0869ec3692cf92022-12-21T21:48:41ZengElsevierJournal of Lipid Research0022-22752016-03-01573492498Effect of fish oil on monoepoxides derived from fatty acids during cardiac surgery1[S]Emmanuel Akintoye0JasonH.Y. Wu1Tao Hou2Xiaoling Song3Jun Yang4Bruce Hammock5Dariush Mozaffarian6Department of Internal Medicine, Wayne State University School of Medicine, Detroit, MIThe George Institute for Global Health, University of Sydney, Sydney, New South Wales, AustraliaHarvard University School of Public Health, Boston, MADivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WADepartment of Entomology and Nematology University of California Davis, Davis, CA; UC Davis Comprehensive Cancer Center, University of California Davis, Davis, CADepartment of Entomology and Nematology University of California Davis, Davis, CA; UC Davis Comprehensive Cancer Center, University of California Davis, Davis, CATo whom correspondence should be addressed; Tufts Friedman School of Nutrition Science & Policy, Boston, MAOur objective was to assess the dynamics of monoepoxides derived from polyunsaturated fatty acids (MEFAs), and their response to n-3 PUFA supplementation, in the setting of acute tissue injury and inflammation (cardiac surgery) in humans. Patients (479) undergoing cardiac surgery in three countries were randomized to perioperative fish oil (EPA + DHA; 8–10 g over 2–5 days preoperatively, then 2 g/day postoperatively) or placebo (olive oil). Plasma MEFAs derived from n-3 and n-6 PUFAs were measured 2 days postoperatively. Based on serial measures in a subset of the placebo group, levels of all MEFAs declined substantially following surgery (at postoperative day 2), with declines ranging from 37% to 63% (P < 0.05 each). Compared with placebo at postoperative day 2, levels of EPA- and DHA-derived MEFAs were 40% and 18% higher, respectively (P ≤ 0.004). The n-3 PUFA supplementation did not significantly alter the decline in n-6 PUFA-derived MEFAs. Both enrollment level and changes in plasma phospholipid EPA and DHA were associated with their respective MEFAs at postoperative day 2 (P < 0.001). Under the acute stress of cardiac surgery, n-3 PUFA supplementation significantly ameliorated the reduction in postoperative n-3 MEFAs, but not n-6 MEFAs, and the degree of increase in n-3 MEFAs related positively to the circulating level of their n-3 PUFA precursors.http://www.sciencedirect.com/science/article/pii/S0022227520354481diet and dietary lipidsinflammationomega-3 fatty acidsphospholipidsvascular biologyrandomized controlled trial |
| spellingShingle | Emmanuel Akintoye JasonH.Y. Wu Tao Hou Xiaoling Song Jun Yang Bruce Hammock Dariush Mozaffarian Effect of fish oil on monoepoxides derived from fatty acids during cardiac surgery1[S] Journal of Lipid Research diet and dietary lipids inflammation omega-3 fatty acids phospholipids vascular biology randomized controlled trial |
| title | Effect of fish oil on monoepoxides derived from fatty acids during cardiac surgery1[S] |
| title_full | Effect of fish oil on monoepoxides derived from fatty acids during cardiac surgery1[S] |
| title_fullStr | Effect of fish oil on monoepoxides derived from fatty acids during cardiac surgery1[S] |
| title_full_unstemmed | Effect of fish oil on monoepoxides derived from fatty acids during cardiac surgery1[S] |
| title_short | Effect of fish oil on monoepoxides derived from fatty acids during cardiac surgery1[S] |
| title_sort | effect of fish oil on monoepoxides derived from fatty acids during cardiac surgery1 s |
| topic | diet and dietary lipids inflammation omega-3 fatty acids phospholipids vascular biology randomized controlled trial |
| url | http://www.sciencedirect.com/science/article/pii/S0022227520354481 |
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