| Summary: | Background: Early detection of the disease in its latent phase through executive health checkup facilitates timely therapeutic interventions, thereby significantly reducing the associated morbidity, mortality and economic burden. Objectives: To evaluate the physiological determinants of health and disease in executive health checkup. Methods: In this hospital-based, cross-sectional study, a total of 768 individuals aged >20 years, irrespective of their gender, reporting for an executive health check-up were included. Demographic parameters, radiological examinations and psychological wellbeing score were evaluated and compared. Data were analyzed using statistical software R version 3.6.3. Results: The study consisted of 768 patients (515 males and 253 females) and majority of them were aged >40 years, almost 75%. No significant difference was found between demographic variables and mean psychological wellbeing scores, environmental mastery and personal growth (P>0.05). A significant association was found between age and findings of ECT and TMT (P=0.001), between gender and findings of TMT (P=0.01). No positive relation was found between sub-categories of demographic variables with respect to psychological wellbeing. A significant difference was found only between different classes of socioeconomic status with respect to self-acceptance and purpose in life (P=0.08). Conclusion: Age and gender associated abnormal ECG and TMT findings are common physiological determinants found in this study. Executive checkups are integral to health promotion, especially in the current scenario of silent killer diseases; preventive health services reduce eventual demand for medical care, thus, enhancing the economic efficiency.
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