Recent Advances in Studying Age-Associated Lipids Alterations and Dietary Interventions in Mammals
Lipids are involved in a broad spectrum of canonical biological functions, from energy supply and storage by triacylglycerols to membrane formation by sphingolipids, phospholipids and glycolipids. Because of this wide range of functions, there is an overlap between age-associated processes and lipid...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-11-01
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| Series: | Frontiers in Aging |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fragi.2021.773795/full |
| _version_ | 1819040774596067328 |
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| author | Benedikt Gille Christina E. Galuska Beate Fuchs Shahaf Peleg Shahaf Peleg |
| author_facet | Benedikt Gille Christina E. Galuska Beate Fuchs Shahaf Peleg Shahaf Peleg |
| author_sort | Benedikt Gille |
| collection | DOAJ |
| description | Lipids are involved in a broad spectrum of canonical biological functions, from energy supply and storage by triacylglycerols to membrane formation by sphingolipids, phospholipids and glycolipids. Because of this wide range of functions, there is an overlap between age-associated processes and lipid pathways. Lipidome analysis revealed age-related changes in the lipid composition of various tissues in mice and humans, which were also influenced by diet and gender. Some changes in the lipid profile can be linked to the onset of age-related neurodegenerative diseases like Alzheimer’s disease. Furthermore, the excessive accumulation of lipid storage organelles, lipid droplets, has significant implications for the development of inflammaging and non-communicable age-related diseases. Dietary interventions such as caloric restriction, time-restrictive eating, and lipid supplementation have been shown to improve pertinent health metrics or even extend life span and thus modulate aging processes. |
| first_indexed | 2024-12-21T09:14:27Z |
| format | Article |
| id | doaj.art-76c0769431fa4430bcf3df9bc52dfc17 |
| institution | Directory Open Access Journal |
| issn | 2673-6217 |
| language | English |
| last_indexed | 2024-12-21T09:14:27Z |
| publishDate | 2021-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging |
| spelling | doaj.art-76c0769431fa4430bcf3df9bc52dfc172022-12-21T19:09:11ZengFrontiers Media S.A.Frontiers in Aging2673-62172021-11-01210.3389/fragi.2021.773795773795Recent Advances in Studying Age-Associated Lipids Alterations and Dietary Interventions in MammalsBenedikt Gille0Christina E. Galuska1Beate Fuchs2Shahaf Peleg3Shahaf Peleg4Research Group Epigenetics, Metabolism and Longevity, Research Institute for Farm Animal Biology (FBN), Dummerstorf, GermanyCore Facility Metabolomics, Research Institute for Farm Animal Biology (FBN), Dummerstorf, GermanyCore Facility Metabolomics, Research Institute for Farm Animal Biology (FBN), Dummerstorf, GermanyResearch Group Epigenetics, Metabolism and Longevity, Research Institute for Farm Animal Biology (FBN), Dummerstorf, GermanyInstitute of Neuroregeneration and Neurorehabilitation, Qingdao University, Qingdao, ChinaLipids are involved in a broad spectrum of canonical biological functions, from energy supply and storage by triacylglycerols to membrane formation by sphingolipids, phospholipids and glycolipids. Because of this wide range of functions, there is an overlap between age-associated processes and lipid pathways. Lipidome analysis revealed age-related changes in the lipid composition of various tissues in mice and humans, which were also influenced by diet and gender. Some changes in the lipid profile can be linked to the onset of age-related neurodegenerative diseases like Alzheimer’s disease. Furthermore, the excessive accumulation of lipid storage organelles, lipid droplets, has significant implications for the development of inflammaging and non-communicable age-related diseases. Dietary interventions such as caloric restriction, time-restrictive eating, and lipid supplementation have been shown to improve pertinent health metrics or even extend life span and thus modulate aging processes.https://www.frontiersin.org/articles/10.3389/fragi.2021.773795/fullaginglipidhealthy life spanmetabolismdietary intervention |
| spellingShingle | Benedikt Gille Christina E. Galuska Beate Fuchs Shahaf Peleg Shahaf Peleg Recent Advances in Studying Age-Associated Lipids Alterations and Dietary Interventions in Mammals Frontiers in Aging aging lipid healthy life span metabolism dietary intervention |
| title | Recent Advances in Studying Age-Associated Lipids Alterations and Dietary Interventions in Mammals |
| title_full | Recent Advances in Studying Age-Associated Lipids Alterations and Dietary Interventions in Mammals |
| title_fullStr | Recent Advances in Studying Age-Associated Lipids Alterations and Dietary Interventions in Mammals |
| title_full_unstemmed | Recent Advances in Studying Age-Associated Lipids Alterations and Dietary Interventions in Mammals |
| title_short | Recent Advances in Studying Age-Associated Lipids Alterations and Dietary Interventions in Mammals |
| title_sort | recent advances in studying age associated lipids alterations and dietary interventions in mammals |
| topic | aging lipid healthy life span metabolism dietary intervention |
| url | https://www.frontiersin.org/articles/10.3389/fragi.2021.773795/full |
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