Timed-averaged blood pressure showed a J-curve association with stroke in elderly chronic kidney disease patients
Background The risk factors for stroke in elderly patients with chronic kidney disease (CKD) are not well understood. This study aimed to explore the influence of systolic blood pressure (SBP) on the risk of stroke in a large cohort of elderly patients with stage 3–5 CKD.Methods We retrospectively i...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2022-12-01
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| Series: | Renal Failure |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/0886022X.2022.2131574 |
| _version_ | 1817986234853621760 |
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| author | Chen Fu Dongliang Zhang Haiping Chen Hui Zhang |
| author_facet | Chen Fu Dongliang Zhang Haiping Chen Hui Zhang |
| author_sort | Chen Fu |
| collection | DOAJ |
| description | Background The risk factors for stroke in elderly patients with chronic kidney disease (CKD) are not well understood. This study aimed to explore the influence of systolic blood pressure (SBP) on the risk of stroke in a large cohort of elderly patients with stage 3–5 CKD.Methods We retrospectively identified 665 patients hospitalized in Beijing Friendship Hospital from January 2000 to December 2021. Patients were followed up until the occurrence of stroke or death. Multivariate logistic regression analysis and Cox proportional hazard models were used to analyze the risk factors for stroke according to the presence or absence of CKD. The association between CKD and stroke was further evaluated regarding the role of SBP in the hypertensive population.Results In individuals with CKD, a J-shaped relationship was observed between SBP levels and the risk of stroke. Participants with CKD and an SBP less than 125 mmHg had a significantly higher cumulative stroke survival rate than those whose SBP was between 125 and 139 mmHg. The cumulative stroke survival rate increased progressively for those with SBP higher than 140 mmHg. This J-shaped relationship was not found in patients without CKD.Conclusion In elderly patients with CKD, those with the lowest BP are at increased risk for incident stroke. This phenomenon could be different from that in the general population. |
| first_indexed | 2024-04-14T00:07:48Z |
| format | Article |
| id | doaj.art-76c1535468fc4f1a8ce9da45306c1ac1 |
| institution | Directory Open Access Journal |
| issn | 0886-022X 1525-6049 |
| language | English |
| last_indexed | 2024-04-14T00:07:48Z |
| publishDate | 2022-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Renal Failure |
| spelling | doaj.art-76c1535468fc4f1a8ce9da45306c1ac12022-12-22T02:23:29ZengTaylor & Francis GroupRenal Failure0886-022X1525-60492022-12-014411677168610.1080/0886022X.2022.2131574Timed-averaged blood pressure showed a J-curve association with stroke in elderly chronic kidney disease patientsChen Fu0Dongliang Zhang1Haiping Chen2Hui Zhang3Department of Nephrology, Beijing Jishuitan Hospital, Beijing, ChinaDepartment of Nephrology, Beijing Jishuitan Hospital, Beijing, ChinaDepartment of Geriatric Nephrology, Medical and Health Care Center, Beijing Friendship Hospital (affiliated with Capital Medical University), Beijing, ChinaDepartment of Nephrology, Tianjin Hospital, Tianjin, ChinaBackground The risk factors for stroke in elderly patients with chronic kidney disease (CKD) are not well understood. This study aimed to explore the influence of systolic blood pressure (SBP) on the risk of stroke in a large cohort of elderly patients with stage 3–5 CKD.Methods We retrospectively identified 665 patients hospitalized in Beijing Friendship Hospital from January 2000 to December 2021. Patients were followed up until the occurrence of stroke or death. Multivariate logistic regression analysis and Cox proportional hazard models were used to analyze the risk factors for stroke according to the presence or absence of CKD. The association between CKD and stroke was further evaluated regarding the role of SBP in the hypertensive population.Results In individuals with CKD, a J-shaped relationship was observed between SBP levels and the risk of stroke. Participants with CKD and an SBP less than 125 mmHg had a significantly higher cumulative stroke survival rate than those whose SBP was between 125 and 139 mmHg. The cumulative stroke survival rate increased progressively for those with SBP higher than 140 mmHg. This J-shaped relationship was not found in patients without CKD.Conclusion In elderly patients with CKD, those with the lowest BP are at increased risk for incident stroke. This phenomenon could be different from that in the general population.https://www.tandfonline.com/doi/10.1080/0886022X.2022.2131574Chronic kidney diseaseelderly populationstrokeblood pressureJ-curve |
| spellingShingle | Chen Fu Dongliang Zhang Haiping Chen Hui Zhang Timed-averaged blood pressure showed a J-curve association with stroke in elderly chronic kidney disease patients Renal Failure Chronic kidney disease elderly population stroke blood pressure J-curve |
| title | Timed-averaged blood pressure showed a J-curve association with stroke in elderly chronic kidney disease patients |
| title_full | Timed-averaged blood pressure showed a J-curve association with stroke in elderly chronic kidney disease patients |
| title_fullStr | Timed-averaged blood pressure showed a J-curve association with stroke in elderly chronic kidney disease patients |
| title_full_unstemmed | Timed-averaged blood pressure showed a J-curve association with stroke in elderly chronic kidney disease patients |
| title_short | Timed-averaged blood pressure showed a J-curve association with stroke in elderly chronic kidney disease patients |
| title_sort | timed averaged blood pressure showed a j curve association with stroke in elderly chronic kidney disease patients |
| topic | Chronic kidney disease elderly population stroke blood pressure J-curve |
| url | https://www.tandfonline.com/doi/10.1080/0886022X.2022.2131574 |
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