Cell Penetrating Capacity and Internalization Mechanisms Used by the Synthetic Peptide CIGB-552 and Its Relationship with Tumor Cell Line Sensitivity

Cell Penetrating Capacity and Internalization Mechanisms Used by the Synthetic Peptide CIGB-552 and Its Relationship with Tumor Cell Line Sensitivity

CIGB-552 is a twenty-amino-acid novel synthetic peptide that has proven to be effective in reducing tumor size and increasing lifespan in tumor-bearing mice. Such capability is conferred by its cell-penetrating peptide character, which allows it to enter cells and elicit a pro-apoptotic effect throu...

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Bibliographic Details
Main Authors: Soledad Astrada, Julio Raúl Fernández Massó, Maribel G. Vallespí, Mariela Bollati-Fogolín
Format: Article
Language:English
Published: MDPI AG 2018-03-01
Series:Molecules
Subjects:
cell penetrating peptide
endocytosis
transduction
Online Access:http://www.mdpi.com/1420-3049/23/4/801

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