Thermal ablation in pancreatic cancer: A scoping review of clinical studies
BackgroundPancreatic cancer is a deadly cancer with a 5-year survival rate less than 10%. Only 20% of patients are eligible to receive surgery at diagnosis. Hence, new therapies are needed to improve outcomes for non-surgical candidates. Thermal ablation techniques can offer a non-invasive alternati...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.1066990/full |
| _version_ | 1811323027845021696 |
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| author | William Farmer William Farmer Gary Hannon Gary Hannon Shubhrima Ghosh Shubhrima Ghosh Adriele Prina-Mello Adriele Prina-Mello Adriele Prina-Mello |
| author_facet | William Farmer William Farmer Gary Hannon Gary Hannon Shubhrima Ghosh Shubhrima Ghosh Adriele Prina-Mello Adriele Prina-Mello Adriele Prina-Mello |
| author_sort | William Farmer |
| collection | DOAJ |
| description | BackgroundPancreatic cancer is a deadly cancer with a 5-year survival rate less than 10%. Only 20% of patients are eligible to receive surgery at diagnosis. Hence, new therapies are needed to improve outcomes for non-surgical candidates. Thermal ablation techniques can offer a non-invasive alternative to surgery.AimThe aim of this review is to map the literature for the use of thermal ablative techniques: Radiofrequency ablation (RFA), High-intensity focused ultrasound (HIFU), Microwave ablation (MWA), and Laser ablation (LA) in the management of patients with PC.MethodsA search strategy was applied to PUBMED and EMBASE using keywords concerning pancreatic cancer, radiofrequency ablation, ultrasound ablation, laser ablation, and microwave ablation. The studies that fit this inclusion criteria were summarized in table format and results reviewed for interpretation.Results72 clinical studies were included. Most of the included studies related to RFA (n=35) and HIFU (n=27). The most common study design was retrospective (n=33). Only 3 randomized control trials (RCT) were included, all of which related to RFA. Safety outcomes were reported in 53 of the 72 studies, and survival outcomes were reported in 39. Statistically significant survival benefits were demonstrated in 11 studies.ConclusionThe evidence for the benefit of MWA and LA in PC patients is limited. RFA and HIFU are safe and feasible therapies to be used in PC patients. Further RCTs where thermal techniques are standardized and reported are necessary in the future to elucidate thermal ablation’s clinical utility, and before an evidence-based decision on its routine use in PC management can be considered. |
| first_indexed | 2024-04-13T13:46:45Z |
| format | Article |
| id | doaj.art-76c221a7af9f4c09a6ac71648aa5b9fa |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-13T13:46:45Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-76c221a7af9f4c09a6ac71648aa5b9fa2022-12-22T02:44:27ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-11-011210.3389/fonc.2022.10669901066990Thermal ablation in pancreatic cancer: A scoping review of clinical studiesWilliam Farmer0William Farmer1Gary Hannon2Gary Hannon3Shubhrima Ghosh4Shubhrima Ghosh5Adriele Prina-Mello6Adriele Prina-Mello7Adriele Prina-Mello8Nanomedicine and Molecular Imaging Group, Trinity Translational Medicine Institute, Dublin, IrelandLaboratory of Biological Characterization of Advanced Materials (LBCAM), Trinity Translational Medicine Institute, Trinity College Dublin, Dublin, IrelandNanomedicine and Molecular Imaging Group, Trinity Translational Medicine Institute, Dublin, IrelandLaboratory of Biological Characterization of Advanced Materials (LBCAM), Trinity Translational Medicine Institute, Trinity College Dublin, Dublin, IrelandNanomedicine and Molecular Imaging Group, Trinity Translational Medicine Institute, Dublin, IrelandLaboratory of Biological Characterization of Advanced Materials (LBCAM), Trinity Translational Medicine Institute, Trinity College Dublin, Dublin, IrelandNanomedicine and Molecular Imaging Group, Trinity Translational Medicine Institute, Dublin, IrelandLaboratory of Biological Characterization of Advanced Materials (LBCAM), Trinity Translational Medicine Institute, Trinity College Dublin, Dublin, IrelandAdvanced Materials and Bioengineering Research (AMBER) Centre, Centre for Research on Adaptive Nanostructures and Nanodevices (CRANN) Institute, Trinity College Dublin, Dublin, IrelandBackgroundPancreatic cancer is a deadly cancer with a 5-year survival rate less than 10%. Only 20% of patients are eligible to receive surgery at diagnosis. Hence, new therapies are needed to improve outcomes for non-surgical candidates. Thermal ablation techniques can offer a non-invasive alternative to surgery.AimThe aim of this review is to map the literature for the use of thermal ablative techniques: Radiofrequency ablation (RFA), High-intensity focused ultrasound (HIFU), Microwave ablation (MWA), and Laser ablation (LA) in the management of patients with PC.MethodsA search strategy was applied to PUBMED and EMBASE using keywords concerning pancreatic cancer, radiofrequency ablation, ultrasound ablation, laser ablation, and microwave ablation. The studies that fit this inclusion criteria were summarized in table format and results reviewed for interpretation.Results72 clinical studies were included. Most of the included studies related to RFA (n=35) and HIFU (n=27). The most common study design was retrospective (n=33). Only 3 randomized control trials (RCT) were included, all of which related to RFA. Safety outcomes were reported in 53 of the 72 studies, and survival outcomes were reported in 39. Statistically significant survival benefits were demonstrated in 11 studies.ConclusionThe evidence for the benefit of MWA and LA in PC patients is limited. RFA and HIFU are safe and feasible therapies to be used in PC patients. Further RCTs where thermal techniques are standardized and reported are necessary in the future to elucidate thermal ablation’s clinical utility, and before an evidence-based decision on its routine use in PC management can be considered.https://www.frontiersin.org/articles/10.3389/fonc.2022.1066990/fullthermal ablationpancreatic cancerradiofrequency ablationhigh-intensity focused ultrasoundmicrowave ablationlaser ablation |
| spellingShingle | William Farmer William Farmer Gary Hannon Gary Hannon Shubhrima Ghosh Shubhrima Ghosh Adriele Prina-Mello Adriele Prina-Mello Adriele Prina-Mello Thermal ablation in pancreatic cancer: A scoping review of clinical studies Frontiers in Oncology thermal ablation pancreatic cancer radiofrequency ablation high-intensity focused ultrasound microwave ablation laser ablation |
| title | Thermal ablation in pancreatic cancer: A scoping review of clinical studies |
| title_full | Thermal ablation in pancreatic cancer: A scoping review of clinical studies |
| title_fullStr | Thermal ablation in pancreatic cancer: A scoping review of clinical studies |
| title_full_unstemmed | Thermal ablation in pancreatic cancer: A scoping review of clinical studies |
| title_short | Thermal ablation in pancreatic cancer: A scoping review of clinical studies |
| title_sort | thermal ablation in pancreatic cancer a scoping review of clinical studies |
| topic | thermal ablation pancreatic cancer radiofrequency ablation high-intensity focused ultrasound microwave ablation laser ablation |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.1066990/full |
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