Role of meningeal immunity in brain function and protection against pathogens
Abstract The brain and spinal cord collectively referred to as the Central Nervous System (CNS) are protected by the blood-brain barrier that limits molecular, microbial and immunological trafficking. However, in the last decade, many studies have emphasized the protective role of ‘border regions’ a...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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BMC
2024-01-01
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| Series: | Journal of Inflammation |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12950-023-00374-7 |
| _version_ | 1827328611342876672 |
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| author | Julie Rebejac Elisa Eme-Scolan Rejane Rua |
| author_facet | Julie Rebejac Elisa Eme-Scolan Rejane Rua |
| author_sort | Julie Rebejac |
| collection | DOAJ |
| description | Abstract The brain and spinal cord collectively referred to as the Central Nervous System (CNS) are protected by the blood-brain barrier that limits molecular, microbial and immunological trafficking. However, in the last decade, many studies have emphasized the protective role of ‘border regions’ at the surface of the CNS which are highly immunologically active, in contrast with the CNS parenchyma. In the steady-state, lymphoid and myeloid cells residing in the cranial meninges can affect brain function and behavior. Upon infection, they provide a first layer of protection against microbial neuroinvasion. The maturation of border sites over time enables more effective brain protection in adults as compared to neonates. Here, we provide a comprehensive update on the meningeal immune system and its role in physiological brain function and protection against infectious agents. |
| first_indexed | 2024-03-07T15:20:00Z |
| format | Article |
| id | doaj.art-76c36efec1c04a51b71a33abedcb785f |
| institution | Directory Open Access Journal |
| issn | 1476-9255 |
| language | English |
| last_indexed | 2024-03-07T15:20:00Z |
| publishDate | 2024-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Inflammation |
| spelling | doaj.art-76c36efec1c04a51b71a33abedcb785f2024-03-05T17:41:14ZengBMCJournal of Inflammation1476-92552024-01-012111810.1186/s12950-023-00374-7Role of meningeal immunity in brain function and protection against pathogensJulie Rebejac0Elisa Eme-Scolan1Rejane Rua2Centre d’Immunologie de Marseille-Luminy, Aix Marseille Université, Inserm, CNRSCentre d’Immunologie de Marseille-Luminy, Aix Marseille Université, Inserm, CNRSCentre d’Immunologie de Marseille-Luminy, Aix Marseille Université, Inserm, CNRSAbstract The brain and spinal cord collectively referred to as the Central Nervous System (CNS) are protected by the blood-brain barrier that limits molecular, microbial and immunological trafficking. However, in the last decade, many studies have emphasized the protective role of ‘border regions’ at the surface of the CNS which are highly immunologically active, in contrast with the CNS parenchyma. In the steady-state, lymphoid and myeloid cells residing in the cranial meninges can affect brain function and behavior. Upon infection, they provide a first layer of protection against microbial neuroinvasion. The maturation of border sites over time enables more effective brain protection in adults as compared to neonates. Here, we provide a comprehensive update on the meningeal immune system and its role in physiological brain function and protection against infectious agents.https://doi.org/10.1186/s12950-023-00374-7MeningesCentral nervous systemInfectionsMeningitisCognition |
| spellingShingle | Julie Rebejac Elisa Eme-Scolan Rejane Rua Role of meningeal immunity in brain function and protection against pathogens Journal of Inflammation Meninges Central nervous system Infections Meningitis Cognition |
| title | Role of meningeal immunity in brain function and protection against pathogens |
| title_full | Role of meningeal immunity in brain function and protection against pathogens |
| title_fullStr | Role of meningeal immunity in brain function and protection against pathogens |
| title_full_unstemmed | Role of meningeal immunity in brain function and protection against pathogens |
| title_short | Role of meningeal immunity in brain function and protection against pathogens |
| title_sort | role of meningeal immunity in brain function and protection against pathogens |
| topic | Meninges Central nervous system Infections Meningitis Cognition |
| url | https://doi.org/10.1186/s12950-023-00374-7 |
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