Association of Multiple Glycemic Parameters at Hospital Admission with Mortality and Short-Term Outcomes in Acutely Poisoned Patients
The prognostic value of multiple glycemic parameters in poisoned patients was never assessed. We aim to explore the effects of glucose variability on short-term outcomes in nondiabetic and diabetic patients acutely poisoned with undifferentiated xenobiotics. We performed a prospective observational...
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MDPI AG
2021-02-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/11/2/361 |
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| author | Catalina Lionte Cristina Bologa Inga Agafiti Victorita Sorodoc Ovidiu Rusalim Petris Elisabeta Jaba Laurentiu Sorodoc |
| author_facet | Catalina Lionte Cristina Bologa Inga Agafiti Victorita Sorodoc Ovidiu Rusalim Petris Elisabeta Jaba Laurentiu Sorodoc |
| author_sort | Catalina Lionte |
| collection | DOAJ |
| description | The prognostic value of multiple glycemic parameters in poisoned patients was never assessed. We aim to explore the effects of glucose variability on short-term outcomes in nondiabetic and diabetic patients acutely poisoned with undifferentiated xenobiotics. We performed a prospective observational study in a tertiary center for toxicology in northeastern Romania. Over the course of 3 years, we included 1076 adults, older than 18 years, admitted for acute poisoning with a xenobiotic. The mortality rate was 4.1%. The admission blood glucose level (BGL) predicted mortality (OR 1.015, 95% CI 1.011–1.019, <i>p</i> < 0.001) and complications (OR 1.005, 95% CI 1.001–1.009, <i>p</i> 0.02). The mean glucose level (MGL) after admission (OR 1.007, 95% CI 1.000–1.013, <i>p</i> 0.034) and coefficient of glucose variability (CV) were predictive for complications (OR 40.58, 95% CI 1.35–1220.52, <i>p</i> 0.033), using the same multivariable model. The receiver operating characteristic curve (ROC) analysis revealed that BGL had good predictive value for in-hospital mortality (area under the curve (AUC) = 0.744, 95% CI = 0.648–0.841, <i>p</i> < 0.001), and complications (AUC = 0.618, 95% CI = 0.584–0.653, <i>p</i> < 0.001). In patients acutely poisoned with xenobiotics, the BGL, MGL and CV can be useful as mortality and short-outcome predictors. |
| first_indexed | 2024-03-09T00:40:42Z |
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| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-09T00:40:42Z |
| publishDate | 2021-02-01 |
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| series | Diagnostics |
| spelling | doaj.art-76c528c7802c4338b7421912da8543dd2023-12-11T17:51:12ZengMDPI AGDiagnostics2075-44182021-02-0111236110.3390/diagnostics11020361Association of Multiple Glycemic Parameters at Hospital Admission with Mortality and Short-Term Outcomes in Acutely Poisoned PatientsCatalina Lionte0Cristina Bologa1Inga Agafiti2Victorita Sorodoc3Ovidiu Rusalim Petris4Elisabeta Jaba5Laurentiu Sorodoc6Internal Medicine and Clinical Toxicology Department, Faculty of Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, RomaniaInternal Medicine and Clinical Toxicology Department, Faculty of Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, Romania2nd Internal Medicine Clinic, “Sf. Spiridon” Emergency Clinic County Hospital, 700111 Iasi, RomaniaInternal Medicine and Clinical Toxicology Department, Faculty of Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, Romania2nd Internal Medicine Clinic, “Sf. Spiridon” Emergency Clinic County Hospital, 700111 Iasi, RomaniaStatistics Department, FEEA, “Alexandru Ioan Cuza” University, 700506 Iasi, RomaniaInternal Medicine and Clinical Toxicology Department, Faculty of Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, RomaniaThe prognostic value of multiple glycemic parameters in poisoned patients was never assessed. We aim to explore the effects of glucose variability on short-term outcomes in nondiabetic and diabetic patients acutely poisoned with undifferentiated xenobiotics. We performed a prospective observational study in a tertiary center for toxicology in northeastern Romania. Over the course of 3 years, we included 1076 adults, older than 18 years, admitted for acute poisoning with a xenobiotic. The mortality rate was 4.1%. The admission blood glucose level (BGL) predicted mortality (OR 1.015, 95% CI 1.011–1.019, <i>p</i> < 0.001) and complications (OR 1.005, 95% CI 1.001–1.009, <i>p</i> 0.02). The mean glucose level (MGL) after admission (OR 1.007, 95% CI 1.000–1.013, <i>p</i> 0.034) and coefficient of glucose variability (CV) were predictive for complications (OR 40.58, 95% CI 1.35–1220.52, <i>p</i> 0.033), using the same multivariable model. The receiver operating characteristic curve (ROC) analysis revealed that BGL had good predictive value for in-hospital mortality (area under the curve (AUC) = 0.744, 95% CI = 0.648–0.841, <i>p</i> < 0.001), and complications (AUC = 0.618, 95% CI = 0.584–0.653, <i>p</i> < 0.001). In patients acutely poisoned with xenobiotics, the BGL, MGL and CV can be useful as mortality and short-outcome predictors.https://www.mdpi.com/2075-4418/11/2/361glycemiamean glucose levelglucose variabilityoutcomespoisoningxenobiotics |
| spellingShingle | Catalina Lionte Cristina Bologa Inga Agafiti Victorita Sorodoc Ovidiu Rusalim Petris Elisabeta Jaba Laurentiu Sorodoc Association of Multiple Glycemic Parameters at Hospital Admission with Mortality and Short-Term Outcomes in Acutely Poisoned Patients Diagnostics glycemia mean glucose level glucose variability outcomes poisoning xenobiotics |
| title | Association of Multiple Glycemic Parameters at Hospital Admission with Mortality and Short-Term Outcomes in Acutely Poisoned Patients |
| title_full | Association of Multiple Glycemic Parameters at Hospital Admission with Mortality and Short-Term Outcomes in Acutely Poisoned Patients |
| title_fullStr | Association of Multiple Glycemic Parameters at Hospital Admission with Mortality and Short-Term Outcomes in Acutely Poisoned Patients |
| title_full_unstemmed | Association of Multiple Glycemic Parameters at Hospital Admission with Mortality and Short-Term Outcomes in Acutely Poisoned Patients |
| title_short | Association of Multiple Glycemic Parameters at Hospital Admission with Mortality and Short-Term Outcomes in Acutely Poisoned Patients |
| title_sort | association of multiple glycemic parameters at hospital admission with mortality and short term outcomes in acutely poisoned patients |
| topic | glycemia mean glucose level glucose variability outcomes poisoning xenobiotics |
| url | https://www.mdpi.com/2075-4418/11/2/361 |
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