PPAR Gamma Agonist Leriglitazone Recovers Alterations Due to Pank2-Deficiency in hiPS-Derived Astrocytes

PPAR Gamma Agonist Leriglitazone Recovers Alterations Due to Pank2-Deficiency in hiPS-Derived Astrocytes

The novel brain-penetrant peroxisome proliferator-activated receptor gamma agonist leriglitazone, previously validated for other rare neurodegenerative diseases, is a small molecule that acts as a regulator of mitochondrial function and exerts neuroprotective, anti-oxidative and anti-inflammatory ef...

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Bibliographic Details
Main Authors:	Paolo Santambrogio, Anna Cozzi, Ivano Di Meo, Chiara Cavestro, Cristina Vergara, Laura Rodríguez-Pascau, Marc Martinell, Pilar Pizcueta, Valeria Tiranti, Sonia Levi
Format:	Article
Language:	English
Published:	MDPI AG 2023-01-01
Series:	Pharmaceutics
Subjects:	pantothenate kinase-2 associated neurodegeneration leriglitazone hiPS-derived astrocytes nuerodegeneration with brain iron accumulation
Online Access:	https://www.mdpi.com/1999-4923/15/1/202

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