Retinal vascular abnormalities and their associations with cardiovascular and cerebrovascular diseases: a Study in rural southwestern Harbin, China
Abstract Background Limited data is available on retinal vessel morphology in the north China. The study aimed to evaluate the prevalence of retinal vascular abnormalities (RVAs) and investigate their associations with the self-reported diagnosis of cardiovascular and cerebrovascsular diseases (CCVd...
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| Format: | Article |
| Language: | English |
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BMC
2020-04-01
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| Series: | BMC Ophthalmology |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12886-020-01407-y |
| _version_ | 1819162192571793408 |
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| author | Junwei Wang Fei Leng Zhijian Li Xianling Tang Hua Qian Xiaoguang Li Yi Zhang Xuedong Chen Haitao Du Ping Liu |
| author_facet | Junwei Wang Fei Leng Zhijian Li Xianling Tang Hua Qian Xiaoguang Li Yi Zhang Xuedong Chen Haitao Du Ping Liu |
| author_sort | Junwei Wang |
| collection | DOAJ |
| description | Abstract Background Limited data is available on retinal vessel morphology in the north China. The study aimed to evaluate the prevalence of retinal vascular abnormalities (RVAs) and investigate their associations with the self-reported diagnosis of cardiovascular and cerebrovascsular diseases (CCVds) in a rural adult population of northeast China. Methods A population-based, cross-sectional study was conducted, using the cluster random sampling method. One eye of each participant was photographed with a non-mydriatic fundus camera. RVAs including focal and general arteriolar narrowing (FAN and GAN), arteriovenous nicking (AVN), arteriolar sheathing (AS), and retinopathy were evaluated. Data on self-reported diagnosis of cardiovascular and cerebrovascular diseases and status of smoking and alcohol drinking were obtained from questionnaires. Results Among the 6267 participants with an age ≥ 50 years, photographs were obtained of 99.2%, with quality sufficient to perform retinal evaluations in 82.5%. The prevalence of FAN, AVN, AS, retinopathy and GAN were 9.1, 8.9, 5.0, 6.6 and 6.2%, respectively. All the retinal lesions were associated with hypertension (all P < 0.01). After adjusting for age, gender, and left/right eyes, hypertension, hyperlipidaemia, diabetes mellitus, habits of past or current smoking and alcohol consumption, AVN was strongly associated with the self-reported diagnosis histories of coronary heart diseases(CHD) (OR, 1.44; 95% CI, 1.09, 1.89) and retinopathy was significantly associated with a self-reported diagnosis of stroke (OR, 2.05; 95% CI, 1.18, 3.57). Conclusions The overall prevalence of retinal microvascular abnormalities in this population was relatively higher than that reported in other regions of the world. Retinopathy is associated with the self-reported diagnosis of stroke while AVN was associated with the self-reported diagnosis of CHD, but the remaining retinal lesions were not consistently associated with CCVds. Thus, an examination of retinal microvascular characteristics may offer clues to CCVds and could be a potentially novel biomarkers for CCVds risk. |
| first_indexed | 2024-12-22T17:24:20Z |
| format | Article |
| id | doaj.art-76cb5b2b32a146e68bafe7ee14e53643 |
| institution | Directory Open Access Journal |
| issn | 1471-2415 |
| language | English |
| last_indexed | 2024-12-22T17:24:20Z |
| publishDate | 2020-04-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Ophthalmology |
| spelling | doaj.art-76cb5b2b32a146e68bafe7ee14e536432022-12-21T18:18:46ZengBMCBMC Ophthalmology1471-24152020-04-0120111010.1186/s12886-020-01407-yRetinal vascular abnormalities and their associations with cardiovascular and cerebrovascular diseases: a Study in rural southwestern Harbin, ChinaJunwei Wang0Fei Leng1Zhijian Li2Xianling Tang3Hua Qian4Xiaoguang Li5Yi Zhang6Xuedong Chen7Haitao Du8Ping Liu9Eye Hospital, First Affiliated Hospital, Harbin Medical UniversityEye Hospital, First Affiliated Hospital, Harbin Medical UniversityEye Hospital, First Affiliated Hospital, Harbin Medical UniversityEye Hospital, First Affiliated Hospital, Harbin Medical UniversityDepartment of Pharmacology, College of Pharmacy, Harbin Medical UniversityDepartment of Pharmacology, College of Pharmacy, Harbin Medical UniversityEye Hospital, First Affiliated Hospital, Harbin Medical UniversityEye Hospital, First Affiliated Hospital, Harbin Medical UniversityEye Hospital, First Affiliated Hospital, Harbin Medical UniversityEye Hospital, First Affiliated Hospital, Harbin Medical UniversityAbstract Background Limited data is available on retinal vessel morphology in the north China. The study aimed to evaluate the prevalence of retinal vascular abnormalities (RVAs) and investigate their associations with the self-reported diagnosis of cardiovascular and cerebrovascsular diseases (CCVds) in a rural adult population of northeast China. Methods A population-based, cross-sectional study was conducted, using the cluster random sampling method. One eye of each participant was photographed with a non-mydriatic fundus camera. RVAs including focal and general arteriolar narrowing (FAN and GAN), arteriovenous nicking (AVN), arteriolar sheathing (AS), and retinopathy were evaluated. Data on self-reported diagnosis of cardiovascular and cerebrovascular diseases and status of smoking and alcohol drinking were obtained from questionnaires. Results Among the 6267 participants with an age ≥ 50 years, photographs were obtained of 99.2%, with quality sufficient to perform retinal evaluations in 82.5%. The prevalence of FAN, AVN, AS, retinopathy and GAN were 9.1, 8.9, 5.0, 6.6 and 6.2%, respectively. All the retinal lesions were associated with hypertension (all P < 0.01). After adjusting for age, gender, and left/right eyes, hypertension, hyperlipidaemia, diabetes mellitus, habits of past or current smoking and alcohol consumption, AVN was strongly associated with the self-reported diagnosis histories of coronary heart diseases(CHD) (OR, 1.44; 95% CI, 1.09, 1.89) and retinopathy was significantly associated with a self-reported diagnosis of stroke (OR, 2.05; 95% CI, 1.18, 3.57). Conclusions The overall prevalence of retinal microvascular abnormalities in this population was relatively higher than that reported in other regions of the world. Retinopathy is associated with the self-reported diagnosis of stroke while AVN was associated with the self-reported diagnosis of CHD, but the remaining retinal lesions were not consistently associated with CCVds. Thus, an examination of retinal microvascular characteristics may offer clues to CCVds and could be a potentially novel biomarkers for CCVds risk.http://link.springer.com/article/10.1186/s12886-020-01407-yRetinal vascular abnormalitiesRisk factorsCross-sectional studyPrevalenceRural populationCardiovascular and cerebrovascular diseases |
| spellingShingle | Junwei Wang Fei Leng Zhijian Li Xianling Tang Hua Qian Xiaoguang Li Yi Zhang Xuedong Chen Haitao Du Ping Liu Retinal vascular abnormalities and their associations with cardiovascular and cerebrovascular diseases: a Study in rural southwestern Harbin, China BMC Ophthalmology Retinal vascular abnormalities Risk factors Cross-sectional study Prevalence Rural population Cardiovascular and cerebrovascular diseases |
| title | Retinal vascular abnormalities and their associations with cardiovascular and cerebrovascular diseases: a Study in rural southwestern Harbin, China |
| title_full | Retinal vascular abnormalities and their associations with cardiovascular and cerebrovascular diseases: a Study in rural southwestern Harbin, China |
| title_fullStr | Retinal vascular abnormalities and their associations with cardiovascular and cerebrovascular diseases: a Study in rural southwestern Harbin, China |
| title_full_unstemmed | Retinal vascular abnormalities and their associations with cardiovascular and cerebrovascular diseases: a Study in rural southwestern Harbin, China |
| title_short | Retinal vascular abnormalities and their associations with cardiovascular and cerebrovascular diseases: a Study in rural southwestern Harbin, China |
| title_sort | retinal vascular abnormalities and their associations with cardiovascular and cerebrovascular diseases a study in rural southwestern harbin china |
| topic | Retinal vascular abnormalities Risk factors Cross-sectional study Prevalence Rural population Cardiovascular and cerebrovascular diseases |
| url | http://link.springer.com/article/10.1186/s12886-020-01407-y |
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