Impact of ceftolozane/tazobactam concentrations in continuous infusion against extensively drug-resistant Pseudomonas aeruginosa isolates in a hollow-fiber infection model

Impact of ceftolozane/tazobactam concentrations in continuous infusion against extensively drug-resistant Pseudomonas aeruginosa isolates in a hollow-fiber infection model

Abstract Ceftolozane/tazobactam (C/T) has emerged as a potential agent for the treatment of extensively drug-resistant (XDR) Pseudomonas aeruginosa infections. As it is a time-dependent antimicrobial, prolonged infusion may help achieve pharmacokinetic/pharmacodynamic (PK/PD) targets. To compare alt...

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Bibliographic Details
Main Authors: María M. Montero, Sandra Domene-Ochoa, Carla López-Causapé, Sonia Luque, Luisa Sorlí, Núria Campillo, Eduardo Padilla, Núria Prim, Lorena Ferrer-Alapont, Ariadna Angulo-Brunet, Santiago Grau, Antonio Oliver, Juan P. Horcajada
Format: Article
Language:English
Published: Nature Portfolio 2021-11-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-01784-4

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