Three-Component Condensation of β-Ketonitriles, 4-Fluorobenzaldehyde, and Secondary Cyclic Amines

Three-Component Condensation of β-Ketonitriles, 4-Fluorobenzaldehyde, and Secondary Cyclic Amines

A new three-component condensation of β-ketonitriles, 4-fluorobenzaldehyde, and secondary cyclic amines was developed. A possible reaction mechanism has been proposed including Knoevenagel condensation followed by aromatic nucleophilic substitution. It was found that in the case of 3-oxopropanenitri...

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Bibliographic Details
Main Authors:	Dmitry V. Osipov, Kirill S. Korzhenko, Vitaly A. Osyanin
Format:	Article
Language:	English
Published:	MDPI AG 2022-12-01
Series:	Reactions
Subjects:	α-arylidene-β-ketonitriles α-cyanoketones three-component reaction Knoevenagel condensation aromatic nucleophilic substitution
Online Access:	https://www.mdpi.com/2624-781X/3/4/42

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