MOLECULAR GENETICS STUDY FUNCTIONING POLYMORPHIC GENE VARIANTS CYTOKINE NETWORK AND BIOTRANSFORMATION OF XENOBIOTICS FOR CANCER

MOLECULAR GENETICS STUDY FUNCTIONING POLYMORPHIC GENE VARIANTS CYTOKINE NETWORK AND BIOTRANSFORMATION OF XENOBIOTICS FOR CANCER

The interrelation of polymorphic loci genes  cytokine profile with indicators spontaneous cytokine  production oxists.  Combination of  genotypes identified family interleukin  -1, and having functional significance adaptive " mutant " alleles (* E2/* II /* C) in the genes of the interleuk...

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Bibliographic Details
Main Authors: E. V. Vorobyeva, E. M. Vasilyeva, G F. Galikeeva, V. Y. Gorbunova
Format: Article
Language:English
Published: Bashkir State Medical University 2017-02-01
Series:Креативная хирургия и онкология
Subjects:
cytokines
tumor suppressor gene
serum cytokines indices
genetic typing
Online Access:https://www.surgonco.ru/jour/article/view/187
Description
Summary:The interrelation of polymorphic loci genes  cytokine profile with indicators spontaneous cytokine  production oxists.  Combination of  genotypes identified family interleukin  -1, and having functional significance adaptive " mutant " alleles (* E2/* II /* C) in the genes of the interleukin -1 was significantly  more frequent in cancer patients " risk" alleles of the tumor  suppressor gene TP53. It’s revealed that  the cancer patients in the combined genotype " mutant " alleles in the gene not only NQO1, but also genes of the interleukin -1 wich where studied.
ISSN:2076-3093
2307-0501

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