Human Leukocyte Antigen Typing Using a Knowledge Base Coupled with a High Throughput Oligonucleotide Probe Array Analysis

Human Leukocyte Antigen Typing Using a Knowledge Base Coupled with a High Throughput Oligonucleotide Probe Array Analysis

Human leukocyte antigens (HLA) are important biomarkers since multiple diseases, drug toxicity, and vaccine responses reveal strong HLA associations. Current clinical HLA typing is an elimination process requiring serial testing. We present an alternative an in situ synthesized DNA-based microarray...

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Bibliographic Details
Main Author: Vladimir eBrusic
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-11-01
Series:Frontiers in Immunology
Subjects:
High-Throughput Screening Assays
machine learning
HLA typing
HLA disease association
population typing
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00597/full

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