Gynecologic Malignancies in Children and Adolescents: How Common is the Uncommon?
The aim of this study is to assess the projected incidence and prognostic indicators of gynecologic malignancies in the pediatric population. In this population-based retrospective cohort study, girls ≤18 years with ovarian, uterine, cervical, vaginal and vulvar malignancies diagnosed between 2000 a...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-02-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/10/4/722 |
| _version_ | 1797396790903832576 |
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| author | Christoph Wohlmuth Iris Wohlmuth-Wieser |
| author_facet | Christoph Wohlmuth Iris Wohlmuth-Wieser |
| author_sort | Christoph Wohlmuth |
| collection | DOAJ |
| description | The aim of this study is to assess the projected incidence and prognostic indicators of gynecologic malignancies in the pediatric population. In this population-based retrospective cohort study, girls ≤18 years with ovarian, uterine, cervical, vaginal and vulvar malignancies diagnosed between 2000 and 2016 were identified from the Surveillance, Epidemiology and End Results (SEER)-18 registry. The Kaplan–Meier method was used to analyze overall survival (OS). The age-adjusted annual incidence of gynecologic malignancies was 6.7 per 1,000,000 females, with neoplasms of the ovary accounting for 87.5%, vagina 4.5%, cervix 3.9%, uterus 2.5% and vulva 1.6% of all gynecologic malignancies. Malignant germ-cell tumors represented the most common ovarian neoplasm, with an increased incidence in children from 5–18 years. Although certain subtypes were associated with advanced disease stages, the 10-year OS rate was 96.0%. Sarcomas accounted for the majority of vaginal, cervical, uterine and vulvar malignancies. The majority of vaginal neoplasms were observed in girls between 0–4 years, and the 10-year OS rate was 86.1%. Overall, gynecologic malignancies accounted for 4.2% of all malignancies in girls aged 0–18 years and the histologic subtypes and prognosis differed significantly from patients in older age groups. |
| first_indexed | 2024-03-09T00:56:38Z |
| format | Article |
| id | doaj.art-76ce937a719343618af12d5eb5759ed2 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-09T00:56:38Z |
| publishDate | 2021-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-76ce937a719343618af12d5eb5759ed22023-12-11T16:50:15ZengMDPI AGJournal of Clinical Medicine2077-03832021-02-0110472210.3390/jcm10040722Gynecologic Malignancies in Children and Adolescents: How Common is the Uncommon?Christoph Wohlmuth0Iris Wohlmuth-Wieser1Department of Obstetrics and Gynecology, Paracelsus Medical University Salzburg, 5020 Salzburg, AustriaDepartment of Dermatology, Paracelsus Medical University Salzburg, 5020 Salzburg, AustriaThe aim of this study is to assess the projected incidence and prognostic indicators of gynecologic malignancies in the pediatric population. In this population-based retrospective cohort study, girls ≤18 years with ovarian, uterine, cervical, vaginal and vulvar malignancies diagnosed between 2000 and 2016 were identified from the Surveillance, Epidemiology and End Results (SEER)-18 registry. The Kaplan–Meier method was used to analyze overall survival (OS). The age-adjusted annual incidence of gynecologic malignancies was 6.7 per 1,000,000 females, with neoplasms of the ovary accounting for 87.5%, vagina 4.5%, cervix 3.9%, uterus 2.5% and vulva 1.6% of all gynecologic malignancies. Malignant germ-cell tumors represented the most common ovarian neoplasm, with an increased incidence in children from 5–18 years. Although certain subtypes were associated with advanced disease stages, the 10-year OS rate was 96.0%. Sarcomas accounted for the majority of vaginal, cervical, uterine and vulvar malignancies. The majority of vaginal neoplasms were observed in girls between 0–4 years, and the 10-year OS rate was 86.1%. Overall, gynecologic malignancies accounted for 4.2% of all malignancies in girls aged 0–18 years and the histologic subtypes and prognosis differed significantly from patients in older age groups.https://www.mdpi.com/2077-0383/10/4/722gynecologic malignanciespediatric cancergynecologic cancerpediatricadolescentfemale |
| spellingShingle | Christoph Wohlmuth Iris Wohlmuth-Wieser Gynecologic Malignancies in Children and Adolescents: How Common is the Uncommon? Journal of Clinical Medicine gynecologic malignancies pediatric cancer gynecologic cancer pediatric adolescent female |
| title | Gynecologic Malignancies in Children and Adolescents: How Common is the Uncommon? |
| title_full | Gynecologic Malignancies in Children and Adolescents: How Common is the Uncommon? |
| title_fullStr | Gynecologic Malignancies in Children and Adolescents: How Common is the Uncommon? |
| title_full_unstemmed | Gynecologic Malignancies in Children and Adolescents: How Common is the Uncommon? |
| title_short | Gynecologic Malignancies in Children and Adolescents: How Common is the Uncommon? |
| title_sort | gynecologic malignancies in children and adolescents how common is the uncommon |
| topic | gynecologic malignancies pediatric cancer gynecologic cancer pediatric adolescent female |
| url | https://www.mdpi.com/2077-0383/10/4/722 |
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