Role of Known Transient Receptor Potential Vanilloid Channels in Modulating Cardiac Mechanobiology
The transient receptor potential (TRP) channels have been described in almost every mammalian cell type. Several members of the Vanilloid (TRPV) subtype have been found to play important roles in modulating cardiac structure and function through Ca2+ handling in response to systemic and local mechan...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2021-10-01
|
| Series: | Frontiers in Physiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphys.2021.734113/full |
| _version_ | 1830300220984918016 |
|---|---|
| author | Michael Miller Sheryl E. Koch Adam Veteto Adam Veteto Timothy Domeier Jack Rubinstein Jack Rubinstein |
| author_facet | Michael Miller Sheryl E. Koch Adam Veteto Adam Veteto Timothy Domeier Jack Rubinstein Jack Rubinstein |
| author_sort | Michael Miller |
| collection | DOAJ |
| description | The transient receptor potential (TRP) channels have been described in almost every mammalian cell type. Several members of the Vanilloid (TRPV) subtype have been found to play important roles in modulating cardiac structure and function through Ca2+ handling in response to systemic and local mechanobiological cues. In this review, we will consider the most studied TRPV channels in the cardiovascular field; transient receptor potential vanilloid 1 as a modulator of cardiac hypertrophy; transient receptor potential vanilloid 2 as a structural and functional protein; transient receptor potential vanilloid 3 in the development of hypertrophy and myocardial fibrosis; and transient receptor potential vanilloid 4 in its roles modulating the fibrotic and functional responses of the heart to pressure overload. Lastly, we will also review the potential overlapping roles of these channels with other TRP proteins as well as the advances in translational and clinical arenas associated with TRPV channels. |
| first_indexed | 2024-12-19T08:24:00Z |
| format | Article |
| id | doaj.art-76cf874e081d450089f986e156d86824 |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-12-19T08:24:00Z |
| publishDate | 2021-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-76cf874e081d450089f986e156d868242022-12-21T20:29:20ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2021-10-011210.3389/fphys.2021.734113734113Role of Known Transient Receptor Potential Vanilloid Channels in Modulating Cardiac MechanobiologyMichael Miller0Sheryl E. Koch1Adam Veteto2Adam Veteto3Timothy Domeier4Jack Rubinstein5Jack Rubinstein6Department of Medical Pharmacology and Physiology, University of Missouri School of Medicine, Columbia, KY, United StatesDepartment of Internal Medicine, Division of Cardiovascular Health and Disease, College of Medicine, University of Cincinnati Medical Center, Cincinnati, OH, United StatesDepartment of Medical Pharmacology and Physiology, University of Missouri School of Medicine, Columbia, KY, United StatesIonOptix, LLC, Westwood, MA, United StatesDepartment of Medical Pharmacology and Physiology, University of Missouri School of Medicine, Columbia, KY, United StatesDepartment of Internal Medicine, Division of Cardiovascular Health and Disease, College of Medicine, University of Cincinnati Medical Center, Cincinnati, OH, United StatesDivision of Cardiovascular Medicine, Cincinnati Veterans Affairs Medical Center, Cincinnati, OH, United StatesThe transient receptor potential (TRP) channels have been described in almost every mammalian cell type. Several members of the Vanilloid (TRPV) subtype have been found to play important roles in modulating cardiac structure and function through Ca2+ handling in response to systemic and local mechanobiological cues. In this review, we will consider the most studied TRPV channels in the cardiovascular field; transient receptor potential vanilloid 1 as a modulator of cardiac hypertrophy; transient receptor potential vanilloid 2 as a structural and functional protein; transient receptor potential vanilloid 3 in the development of hypertrophy and myocardial fibrosis; and transient receptor potential vanilloid 4 in its roles modulating the fibrotic and functional responses of the heart to pressure overload. Lastly, we will also review the potential overlapping roles of these channels with other TRP proteins as well as the advances in translational and clinical arenas associated with TRPV channels.https://www.frontiersin.org/articles/10.3389/fphys.2021.734113/fullTRPV channelshypertrophycardiomyopathiesfibrosiscardiac fibrosis |
| spellingShingle | Michael Miller Sheryl E. Koch Adam Veteto Adam Veteto Timothy Domeier Jack Rubinstein Jack Rubinstein Role of Known Transient Receptor Potential Vanilloid Channels in Modulating Cardiac Mechanobiology Frontiers in Physiology TRPV channels hypertrophy cardiomyopathies fibrosis cardiac fibrosis |
| title | Role of Known Transient Receptor Potential Vanilloid Channels in Modulating Cardiac Mechanobiology |
| title_full | Role of Known Transient Receptor Potential Vanilloid Channels in Modulating Cardiac Mechanobiology |
| title_fullStr | Role of Known Transient Receptor Potential Vanilloid Channels in Modulating Cardiac Mechanobiology |
| title_full_unstemmed | Role of Known Transient Receptor Potential Vanilloid Channels in Modulating Cardiac Mechanobiology |
| title_short | Role of Known Transient Receptor Potential Vanilloid Channels in Modulating Cardiac Mechanobiology |
| title_sort | role of known transient receptor potential vanilloid channels in modulating cardiac mechanobiology |
| topic | TRPV channels hypertrophy cardiomyopathies fibrosis cardiac fibrosis |
| url | https://www.frontiersin.org/articles/10.3389/fphys.2021.734113/full |
| work_keys_str_mv | AT michaelmiller roleofknowntransientreceptorpotentialvanilloidchannelsinmodulatingcardiacmechanobiology AT sherylekoch roleofknowntransientreceptorpotentialvanilloidchannelsinmodulatingcardiacmechanobiology AT adamveteto roleofknowntransientreceptorpotentialvanilloidchannelsinmodulatingcardiacmechanobiology AT adamveteto roleofknowntransientreceptorpotentialvanilloidchannelsinmodulatingcardiacmechanobiology AT timothydomeier roleofknowntransientreceptorpotentialvanilloidchannelsinmodulatingcardiacmechanobiology AT jackrubinstein roleofknowntransientreceptorpotentialvanilloidchannelsinmodulatingcardiacmechanobiology AT jackrubinstein roleofknowntransientreceptorpotentialvanilloidchannelsinmodulatingcardiacmechanobiology |