The Association Between Epidermal Growth Factor rs3756261 A/G Gene Polymorphism and the Risk of Ankylosing Spondylitis in a Chinese Han Population
Hui Zhang, Wei Jiang Department of Orthopedics, The Affiliated Changzhou No. 2 People’s Hospital of Nanjing Medical University, Changzhou, People’s Republic of ChinaCorrespondence: Wei Jiang, Email jiangweicz@tom.comBackground: Epidermal growth factor (EGF) is a potent pro-angiogenic molecule promot...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2024-03-01
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| Series: | International Journal of General Medicine |
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| Online Access: | https://www.dovepress.com/the-association-between-epidermal-growth-factor-rs3756261-ag-gene-poly-peer-reviewed-fulltext-article-IJGM |
| _version_ | 1797231341359595520 |
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| author | Zhang H Jiang W |
| author_facet | Zhang H Jiang W |
| author_sort | Zhang H |
| collection | DOAJ |
| description | Hui Zhang, Wei Jiang Department of Orthopedics, The Affiliated Changzhou No. 2 People’s Hospital of Nanjing Medical University, Changzhou, People’s Republic of ChinaCorrespondence: Wei Jiang, Email jiangweicz@tom.comBackground: Epidermal growth factor (EGF) is a potent pro-angiogenic molecule promoting the angiogenic phenotype of ankylosing spondylitis (AS). Studies demonstrated that EGF rs3756261 polymorphism was associated with the risk of inflammatory diseases, but not including AS.Methods: To investigate the association between EGF rs3756261 polymorphism and the risk of AS, we genotyped the EGF rs3756261 polymorphism in 208 patients with AS and 412 controls in a Chinese Han population using a custom-by-design 48-Plex SNP scanTM Kit. The serum EGF levels were measured using an enzyme-linked immunosorbent assay in 208 AS patients and 412 controls.Results: Our data indicated that EGF rs3756261 polymorphism was associated with an increased risk of AS in the Chinese Han population. Stratified analyses indicated that the EGF rs3756261 polymorphism elevated the risk of AS among the males, smokers, drinkers and those aged < 30 years. In addition, the EGF rs3756261 polymorphism was related to increased CRP and HLA-B27 levels in AS patients. Next, we found that the average serum levels of EGF were significantly higher in AS patients compared with controls. Meanwhile, EGF serum levels were significantly higher in AG genotype carriers when compared with AA genotype carriers in AS patients.Conclusion: In conclusion, this study indicated that EGF rs3756261 polymorphism was associated with the risk of AS and EGF serum levels in a Chinese Han population.Keywords: EGF, rs3756261 polymorphism, serum levels, ankylosing spondylitis, case–control study |
| first_indexed | 2024-04-24T15:42:50Z |
| format | Article |
| id | doaj.art-76d00415d5ce4a24922d0ad5a1878463 |
| institution | Directory Open Access Journal |
| issn | 1178-7074 |
| language | English |
| last_indexed | 2024-04-24T15:42:50Z |
| publishDate | 2024-03-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | International Journal of General Medicine |
| spelling | doaj.art-76d00415d5ce4a24922d0ad5a18784632024-04-01T18:03:49ZengDove Medical PressInternational Journal of General Medicine1178-70742024-03-01Volume 171213122091576The Association Between Epidermal Growth Factor rs3756261 A/G Gene Polymorphism and the Risk of Ankylosing Spondylitis in a Chinese Han PopulationZhang HJiang WHui Zhang, Wei Jiang Department of Orthopedics, The Affiliated Changzhou No. 2 People’s Hospital of Nanjing Medical University, Changzhou, People’s Republic of ChinaCorrespondence: Wei Jiang, Email jiangweicz@tom.comBackground: Epidermal growth factor (EGF) is a potent pro-angiogenic molecule promoting the angiogenic phenotype of ankylosing spondylitis (AS). Studies demonstrated that EGF rs3756261 polymorphism was associated with the risk of inflammatory diseases, but not including AS.Methods: To investigate the association between EGF rs3756261 polymorphism and the risk of AS, we genotyped the EGF rs3756261 polymorphism in 208 patients with AS and 412 controls in a Chinese Han population using a custom-by-design 48-Plex SNP scanTM Kit. The serum EGF levels were measured using an enzyme-linked immunosorbent assay in 208 AS patients and 412 controls.Results: Our data indicated that EGF rs3756261 polymorphism was associated with an increased risk of AS in the Chinese Han population. Stratified analyses indicated that the EGF rs3756261 polymorphism elevated the risk of AS among the males, smokers, drinkers and those aged < 30 years. In addition, the EGF rs3756261 polymorphism was related to increased CRP and HLA-B27 levels in AS patients. Next, we found that the average serum levels of EGF were significantly higher in AS patients compared with controls. Meanwhile, EGF serum levels were significantly higher in AG genotype carriers when compared with AA genotype carriers in AS patients.Conclusion: In conclusion, this study indicated that EGF rs3756261 polymorphism was associated with the risk of AS and EGF serum levels in a Chinese Han population.Keywords: EGF, rs3756261 polymorphism, serum levels, ankylosing spondylitis, case–control studyhttps://www.dovepress.com/the-association-between-epidermal-growth-factor-rs3756261-ag-gene-poly-peer-reviewed-fulltext-article-IJGMegfrs3756261 polymorphismserum levelsankylosing spondylitiscase-control study. |
| spellingShingle | Zhang H Jiang W The Association Between Epidermal Growth Factor rs3756261 A/G Gene Polymorphism and the Risk of Ankylosing Spondylitis in a Chinese Han Population International Journal of General Medicine egf rs3756261 polymorphism serum levels ankylosing spondylitis case-control study. |
| title | The Association Between Epidermal Growth Factor rs3756261 A/G Gene Polymorphism and the Risk of Ankylosing Spondylitis in a Chinese Han Population |
| title_full | The Association Between Epidermal Growth Factor rs3756261 A/G Gene Polymorphism and the Risk of Ankylosing Spondylitis in a Chinese Han Population |
| title_fullStr | The Association Between Epidermal Growth Factor rs3756261 A/G Gene Polymorphism and the Risk of Ankylosing Spondylitis in a Chinese Han Population |
| title_full_unstemmed | The Association Between Epidermal Growth Factor rs3756261 A/G Gene Polymorphism and the Risk of Ankylosing Spondylitis in a Chinese Han Population |
| title_short | The Association Between Epidermal Growth Factor rs3756261 A/G Gene Polymorphism and the Risk of Ankylosing Spondylitis in a Chinese Han Population |
| title_sort | association between epidermal growth factor rs3756261 a g gene polymorphism and the risk of ankylosing spondylitis in a chinese han population |
| topic | egf rs3756261 polymorphism serum levels ankylosing spondylitis case-control study. |
| url | https://www.dovepress.com/the-association-between-epidermal-growth-factor-rs3756261-ag-gene-poly-peer-reviewed-fulltext-article-IJGM |
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