The effect of erythropoietin treatment on left ventricular hypertrophy in haemodialysis patients
Anaemia appears to play an important role in left ventricular (LV) enlargement in chronic kidney disease patients. The objective of this study was to evaluate LV echocardiography changes during anaemia correction with recombinant human erythropoietin(rHu-Epo) in chronic haemodialysis patients (HD p...
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| Format: | Article |
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Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina
2003-11-01
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| Series: | Biomolecules & Biomedicine |
| Subjects: | |
| Online Access: | https://www.bjbms.org/ojs/index.php/bjbms/article/view/3485 |
| _version_ | 1797260754659835904 |
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| author | Senija Rašić Indira Kulenović Irfan Zulić Azra Haračić Mithat Čengić Snježana Unčanin Jasminka Džemidžić |
| author_facet | Senija Rašić Indira Kulenović Irfan Zulić Azra Haračić Mithat Čengić Snježana Unčanin Jasminka Džemidžić |
| author_sort | Senija Rašić |
| collection | DOAJ |
| description |
Anaemia appears to play an important role in left ventricular (LV) enlargement in chronic kidney disease patients. The objective of this study was to evaluate LV echocardiography changes during anaemia correction with recombinant human erythropoietin(rHu-Epo) in chronic haemodialysis patients (HD pts) with signs of anaemia and LV hypertrophy (LVH). The study included 20 HD pts aged 39,6 +/- 5,3 yrs, with the same condition of HD treatment, anaemia and echocardiographically LVH verified. At the beginning of the rHu-Epo treatment haemoglobin (Hb) level was < 90 g/L and the target Hb level was 110 g/L. Echocardiography was performed at the beginning (baseline) and after six months of rHu-Epo treatment. LVH was defined as LV mass index >100 g/m2 in women and >131 g/m2 in men. We observed significant reduction of LV mass index (LVMI) (mean 26,4%, p=0.008), as well as LV volumen. There was a significant negative correlation between Hb level and LVMI with predictive LVMI reduction of 2,317 g/m2 for each 1g/L rising of mean Hb level. The results of the study confirm the importance of early anaemia correction in haemodialysis patients aimed to improve LV parameters.
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| first_indexed | 2024-04-24T23:30:21Z |
| format | Article |
| id | doaj.art-76d01cde57d547a184124b1d19deb085 |
| institution | Directory Open Access Journal |
| issn | 2831-0896 2831-090X |
| language | English |
| last_indexed | 2024-04-24T23:30:21Z |
| publishDate | 2003-11-01 |
| publisher | Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina |
| record_format | Article |
| series | Biomolecules & Biomedicine |
| spelling | doaj.art-76d01cde57d547a184124b1d19deb0852024-03-15T14:43:47ZengAssociation of Basic Medical Sciences of Federation of Bosnia and HerzegovinaBiomolecules & Biomedicine2831-08962831-090X2003-11-013410.17305/bjbms.2003.3485874The effect of erythropoietin treatment on left ventricular hypertrophy in haemodialysis patientsSenija Rašić0Indira Kulenović1Irfan Zulić2Azra Haračić3Mithat Čengić4Snježana Unčanin5Jasminka Džemidžić6Institute of NephrologyDepartment of Endocrinology and DiabetesInstitute for Pharmacology and Toxicology - Medical Faculty University of SarajevoDepartment of Cardiology - Clinical Centre University of SarajevoInstitute of NephrologyInstitute of NephrologyInstitute of Nephrology Anaemia appears to play an important role in left ventricular (LV) enlargement in chronic kidney disease patients. The objective of this study was to evaluate LV echocardiography changes during anaemia correction with recombinant human erythropoietin(rHu-Epo) in chronic haemodialysis patients (HD pts) with signs of anaemia and LV hypertrophy (LVH). The study included 20 HD pts aged 39,6 +/- 5,3 yrs, with the same condition of HD treatment, anaemia and echocardiographically LVH verified. At the beginning of the rHu-Epo treatment haemoglobin (Hb) level was < 90 g/L and the target Hb level was 110 g/L. Echocardiography was performed at the beginning (baseline) and after six months of rHu-Epo treatment. LVH was defined as LV mass index >100 g/m2 in women and >131 g/m2 in men. We observed significant reduction of LV mass index (LVMI) (mean 26,4%, p=0.008), as well as LV volumen. There was a significant negative correlation between Hb level and LVMI with predictive LVMI reduction of 2,317 g/m2 for each 1g/L rising of mean Hb level. The results of the study confirm the importance of early anaemia correction in haemodialysis patients aimed to improve LV parameters. https://www.bjbms.org/ojs/index.php/bjbms/article/view/3485erythropoietin treatmentleft ventricular hyperthrophyhaemodialysis patients |
| spellingShingle | Senija Rašić Indira Kulenović Irfan Zulić Azra Haračić Mithat Čengić Snježana Unčanin Jasminka Džemidžić The effect of erythropoietin treatment on left ventricular hypertrophy in haemodialysis patients Biomolecules & Biomedicine erythropoietin treatment left ventricular hyperthrophy haemodialysis patients |
| title | The effect of erythropoietin treatment on left ventricular hypertrophy in haemodialysis patients |
| title_full | The effect of erythropoietin treatment on left ventricular hypertrophy in haemodialysis patients |
| title_fullStr | The effect of erythropoietin treatment on left ventricular hypertrophy in haemodialysis patients |
| title_full_unstemmed | The effect of erythropoietin treatment on left ventricular hypertrophy in haemodialysis patients |
| title_short | The effect of erythropoietin treatment on left ventricular hypertrophy in haemodialysis patients |
| title_sort | effect of erythropoietin treatment on left ventricular hypertrophy in haemodialysis patients |
| topic | erythropoietin treatment left ventricular hyperthrophy haemodialysis patients |
| url | https://www.bjbms.org/ojs/index.php/bjbms/article/view/3485 |
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