Correlations between cortical gyrification and schizophrenia symptoms with and without comorbid hostility symptoms
IntroductionInterest in identifying the clinical implications of the neuropathophysiological background of schizophrenia is rising, including changes in cortical gyrification that may be due to neurodevelopmental abnormalities. Inpatients with schizophrenia can show abnormal gyrification of cortical...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-01-01
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| Series: | Frontiers in Psychiatry |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyt.2022.1092784/full |
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| author | Stefano Ferracuti Stefano Ferracuti Antonio Del Casale Antonio Del Casale Andrea Romano Andrea Romano Ida Gualtieri Martina Lucignani Antonio Napolitano Martina Nicole Modesti Martina Nicole Modesti Andrea Buscajoni Teodolinda Zoppi Georgios D. Kotzalidis Lorenza Manelfi Eleonora de Pisa Eleonora de Pisa Paolo Girardi Paolo Girardi Gabriele Mandarelli Giovanna Parmigiani Maria Camilla Rossi-Espagnet Maria Camilla Rossi-Espagnet Maurizio Pompili Maurizio Pompili Alessandro Bozzao Alessandro Bozzao |
| author_facet | Stefano Ferracuti Stefano Ferracuti Antonio Del Casale Antonio Del Casale Andrea Romano Andrea Romano Ida Gualtieri Martina Lucignani Antonio Napolitano Martina Nicole Modesti Martina Nicole Modesti Andrea Buscajoni Teodolinda Zoppi Georgios D. Kotzalidis Lorenza Manelfi Eleonora de Pisa Eleonora de Pisa Paolo Girardi Paolo Girardi Gabriele Mandarelli Giovanna Parmigiani Maria Camilla Rossi-Espagnet Maria Camilla Rossi-Espagnet Maurizio Pompili Maurizio Pompili Alessandro Bozzao Alessandro Bozzao |
| author_sort | Stefano Ferracuti |
| collection | DOAJ |
| description | IntroductionInterest in identifying the clinical implications of the neuropathophysiological background of schizophrenia is rising, including changes in cortical gyrification that may be due to neurodevelopmental abnormalities. Inpatients with schizophrenia can show abnormal gyrification of cortical regions correlated with the symptom severity.MethodsOur study included 36 patients that suffered an acute episode of schizophrenia and have undergone structural magnetic resonance imaging (MRI) to calculate the local gyrification index (LGI).ResultsIn the whole sample, the severity of symptoms significantly correlated with higher LGI in different cortical areas, including bilateral frontal, cingulate, parietal, temporal cortices, and right occipital cortex. Among these areas, patients with low hostility symptoms (LHS) compared to patients with high hostility symptoms (HHS) showed significantly lower LGI related to the severity of symptoms in bilateral frontal and temporal lobes.DiscussionThe severity of psychopathology correlated with higher LGI in large portions of the cerebral cortex, possibly expressing abnormal neural development in schizophrenia. These findings could pave the way for further studies and future tailored diagnostic and therapeutic strategies. |
| first_indexed | 2024-04-11T00:58:22Z |
| format | Article |
| id | doaj.art-76d52d202f1b43f59ccd4d65b9a44040 |
| institution | Directory Open Access Journal |
| issn | 1664-0640 |
| language | English |
| last_indexed | 2024-04-11T00:58:22Z |
| publishDate | 2023-01-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Psychiatry |
| spelling | doaj.art-76d52d202f1b43f59ccd4d65b9a440402023-01-04T21:06:17ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402023-01-011310.3389/fpsyt.2022.10927841092784Correlations between cortical gyrification and schizophrenia symptoms with and without comorbid hostility symptomsStefano Ferracuti0Stefano Ferracuti1Antonio Del Casale2Antonio Del Casale3Andrea Romano4Andrea Romano5Ida Gualtieri6Martina Lucignani7Antonio Napolitano8Martina Nicole Modesti9Martina Nicole Modesti10Andrea Buscajoni11Teodolinda Zoppi12Georgios D. Kotzalidis13Lorenza Manelfi14Eleonora de Pisa15Eleonora de Pisa16Paolo Girardi17Paolo Girardi18Gabriele Mandarelli19Giovanna Parmigiani20Maria Camilla Rossi-Espagnet21Maria Camilla Rossi-Espagnet22Maurizio Pompili23Maurizio Pompili24Alessandro Bozzao25Alessandro Bozzao26Department of Human Neuroscience, Faculty of Medicine and Dentistry, Sapienza University, Rome, ItalyUnit of Risk Management, Sant’Andrea University Hospital, Rome, ItalyDepartment of Dynamic and Clinical Psychology, and Health Studies, Faculty of Medicine and Psychology, Sapienza University, Rome, ItalyUnit of Psychiatry, Sant’Andrea University Hospital, Rome, ItalyDepartment of Neuroscience, Mental Health and Sensory Organs, Faculty of Medicine and Psychology, Sapienza University, Rome, ItalyUnit of Neuroradiology, Sant’Andrea University Hospital, Rome, ItalyDepartment of Neuroscience, Mental Health and Sensory Organs, Faculty of Medicine and Psychology, Sapienza University, Rome, ItalyIRCCS Bambino Gesù, Rome, ItalyIRCCS Bambino Gesù, Rome, ItalyUnit of Psychiatry, Sant’Andrea University Hospital, Rome, ItalyDepartment of Neuroscience, Mental Health and Sensory Organs, Faculty of Medicine and Psychology, Sapienza University, Rome, ItalyDepartment of Neuroscience, Mental Health and Sensory Organs, Faculty of Medicine and Psychology, Sapienza University, Rome, ItalyDepartment of Neuroscience, Mental Health and Sensory Organs, Faculty of Medicine and Psychology, Sapienza University, Rome, ItalyDepartment of Neuroscience, Mental Health and Sensory Organs, Faculty of Medicine and Psychology, Sapienza University, Rome, ItalyDepartment of Neuroscience, Mental Health and Sensory Organs, Faculty of Medicine and Psychology, Sapienza University, Rome, ItalyUnit of Psychiatry, Sant’Andrea University Hospital, Rome, ItalyDepartment of Neuroscience, Mental Health and Sensory Organs, Faculty of Medicine and Psychology, Sapienza University, Rome, ItalyDepartment of Dynamic and Clinical Psychology, and Health Studies, Faculty of Medicine and Psychology, Sapienza University, Rome, ItalyUnit of Psychiatry, Sant’Andrea University Hospital, Rome, ItalyDepartment of Interdisciplinary Medicine, Section of Criminology and Forensic Psychiatry, University of Bari, Bari, ItalyDepartment of Human Neuroscience, Faculty of Medicine and Dentistry, Sapienza University, Rome, ItalyDepartment of Neuroscience, Mental Health and Sensory Organs, Faculty of Medicine and Psychology, Sapienza University, Rome, ItalyDepartment of Interdisciplinary Medicine, Section of Criminology and Forensic Psychiatry, University of Bari, Bari, ItalyUnit of Psychiatry, Sant’Andrea University Hospital, Rome, ItalyDepartment of Neuroscience, Mental Health and Sensory Organs, Faculty of Medicine and Psychology, Sapienza University, Rome, ItalyDepartment of Neuroscience, Mental Health and Sensory Organs, Faculty of Medicine and Psychology, Sapienza University, Rome, ItalyUnit of Neuroradiology, Sant’Andrea University Hospital, Rome, ItalyIntroductionInterest in identifying the clinical implications of the neuropathophysiological background of schizophrenia is rising, including changes in cortical gyrification that may be due to neurodevelopmental abnormalities. Inpatients with schizophrenia can show abnormal gyrification of cortical regions correlated with the symptom severity.MethodsOur study included 36 patients that suffered an acute episode of schizophrenia and have undergone structural magnetic resonance imaging (MRI) to calculate the local gyrification index (LGI).ResultsIn the whole sample, the severity of symptoms significantly correlated with higher LGI in different cortical areas, including bilateral frontal, cingulate, parietal, temporal cortices, and right occipital cortex. Among these areas, patients with low hostility symptoms (LHS) compared to patients with high hostility symptoms (HHS) showed significantly lower LGI related to the severity of symptoms in bilateral frontal and temporal lobes.DiscussionThe severity of psychopathology correlated with higher LGI in large portions of the cerebral cortex, possibly expressing abnormal neural development in schizophrenia. These findings could pave the way for further studies and future tailored diagnostic and therapeutic strategies.https://www.frontiersin.org/articles/10.3389/fpsyt.2022.1092784/fullschizophreniapsychosisneuroimaginggyrificationmagnetic resonance imaginghostility |
| spellingShingle | Stefano Ferracuti Stefano Ferracuti Antonio Del Casale Antonio Del Casale Andrea Romano Andrea Romano Ida Gualtieri Martina Lucignani Antonio Napolitano Martina Nicole Modesti Martina Nicole Modesti Andrea Buscajoni Teodolinda Zoppi Georgios D. Kotzalidis Lorenza Manelfi Eleonora de Pisa Eleonora de Pisa Paolo Girardi Paolo Girardi Gabriele Mandarelli Giovanna Parmigiani Maria Camilla Rossi-Espagnet Maria Camilla Rossi-Espagnet Maurizio Pompili Maurizio Pompili Alessandro Bozzao Alessandro Bozzao Correlations between cortical gyrification and schizophrenia symptoms with and without comorbid hostility symptoms Frontiers in Psychiatry schizophrenia psychosis neuroimaging gyrification magnetic resonance imaging hostility |
| title | Correlations between cortical gyrification and schizophrenia symptoms with and without comorbid hostility symptoms |
| title_full | Correlations between cortical gyrification and schizophrenia symptoms with and without comorbid hostility symptoms |
| title_fullStr | Correlations between cortical gyrification and schizophrenia symptoms with and without comorbid hostility symptoms |
| title_full_unstemmed | Correlations between cortical gyrification and schizophrenia symptoms with and without comorbid hostility symptoms |
| title_short | Correlations between cortical gyrification and schizophrenia symptoms with and without comorbid hostility symptoms |
| title_sort | correlations between cortical gyrification and schizophrenia symptoms with and without comorbid hostility symptoms |
| topic | schizophrenia psychosis neuroimaging gyrification magnetic resonance imaging hostility |
| url | https://www.frontiersin.org/articles/10.3389/fpsyt.2022.1092784/full |
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