Current Strategies to Enhance Adipose Stem Cell Function: An Update
Mesenchymal stem cells (MSCs) emerged as a promising therapeutic tool targeting a variety of inflammatory disorders due to their multiple remarkable properties, such as superior immunomodulatory function and tissue-regenerative capacity. Although bone marrow (BM) is a dominant source for adult MSCs,...
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-08-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/20/15/3827 |
| _version_ | 1811322296927780864 |
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| author | Yoojin Seo Tae-Hoon Shin Hyung-Sik Kim |
| author_facet | Yoojin Seo Tae-Hoon Shin Hyung-Sik Kim |
| author_sort | Yoojin Seo |
| collection | DOAJ |
| description | Mesenchymal stem cells (MSCs) emerged as a promising therapeutic tool targeting a variety of inflammatory disorders due to their multiple remarkable properties, such as superior immunomodulatory function and tissue-regenerative capacity. Although bone marrow (BM) is a dominant source for adult MSCs, increasing evidence suggests that adipose tissue-derived stem cells (ASCs), which can be easily obtained at a relatively high yield, have potent therapeutic advantages comparable with BM-MSCs. Despite its outstanding benefits in pre-clinical settings, the practical efficacy of ASCs remains controversial since clinical trials with ASC application often resulted in unsatisfactory outcomes. To overcome this challenge, scientists established several strategies to generate highly functional ASCs beyond the naïve cells, including (1) pre-conditioning of ASCs with various stimulants such as inflammatory agents, (2) genetic manipulation of ASCs and (3) modification of culture conditions with three-dimensional (3D) aggregate formation and hypoxic culture. Also, exosomes and other extracellular vesicles secreted from ASCs can be applied directly to recapitulate the beneficial performance of ASCs. This review summarizes the current strategies to improve the therapeutic features of ASCs for successful clinical implementation. |
| first_indexed | 2024-04-13T13:32:39Z |
| format | Article |
| id | doaj.art-76d59bd4b0c44b75b1efb04589b4306c |
| institution | Directory Open Access Journal |
| issn | 1422-0067 |
| language | English |
| last_indexed | 2024-04-13T13:32:39Z |
| publishDate | 2019-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-76d59bd4b0c44b75b1efb04589b4306c2022-12-22T02:44:54ZengMDPI AGInternational Journal of Molecular Sciences1422-00672019-08-012015382710.3390/ijms20153827ijms20153827Current Strategies to Enhance Adipose Stem Cell Function: An UpdateYoojin Seo0Tae-Hoon Shin1Hyung-Sik Kim2Dental and Life Science Institute, Pusan National University, Yangsan 50612, KoreaTranslational Stem Cell Biology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USADental and Life Science Institute, Pusan National University, Yangsan 50612, KoreaMesenchymal stem cells (MSCs) emerged as a promising therapeutic tool targeting a variety of inflammatory disorders due to their multiple remarkable properties, such as superior immunomodulatory function and tissue-regenerative capacity. Although bone marrow (BM) is a dominant source for adult MSCs, increasing evidence suggests that adipose tissue-derived stem cells (ASCs), which can be easily obtained at a relatively high yield, have potent therapeutic advantages comparable with BM-MSCs. Despite its outstanding benefits in pre-clinical settings, the practical efficacy of ASCs remains controversial since clinical trials with ASC application often resulted in unsatisfactory outcomes. To overcome this challenge, scientists established several strategies to generate highly functional ASCs beyond the naïve cells, including (1) pre-conditioning of ASCs with various stimulants such as inflammatory agents, (2) genetic manipulation of ASCs and (3) modification of culture conditions with three-dimensional (3D) aggregate formation and hypoxic culture. Also, exosomes and other extracellular vesicles secreted from ASCs can be applied directly to recapitulate the beneficial performance of ASCs. This review summarizes the current strategies to improve the therapeutic features of ASCs for successful clinical implementation.https://www.mdpi.com/1422-0067/20/15/3827adipose stem cellsmesenchymal stem cellsimmunomodulationcell therapyfunction enhancement |
| spellingShingle | Yoojin Seo Tae-Hoon Shin Hyung-Sik Kim Current Strategies to Enhance Adipose Stem Cell Function: An Update International Journal of Molecular Sciences adipose stem cells mesenchymal stem cells immunomodulation cell therapy function enhancement |
| title | Current Strategies to Enhance Adipose Stem Cell Function: An Update |
| title_full | Current Strategies to Enhance Adipose Stem Cell Function: An Update |
| title_fullStr | Current Strategies to Enhance Adipose Stem Cell Function: An Update |
| title_full_unstemmed | Current Strategies to Enhance Adipose Stem Cell Function: An Update |
| title_short | Current Strategies to Enhance Adipose Stem Cell Function: An Update |
| title_sort | current strategies to enhance adipose stem cell function an update |
| topic | adipose stem cells mesenchymal stem cells immunomodulation cell therapy function enhancement |
| url | https://www.mdpi.com/1422-0067/20/15/3827 |
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