Ingestion of mammalian meat and alpha-gal allergy: Clinical relevance in primary care
Background: An allergic reaction to mammalian meat has recently been reported in rural parts of South Africa and throughout other parts of the world. The cause of this allergic reaction is because of an oligosaccharide antigen known as galactose-alpha-1, 3-galactose (alpha-gal) found in mammalian me...
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| Format: | Article |
| Language: | English |
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AOSIS
2019-04-01
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| Series: | African Journal of Primary Health Care & Family Medicine |
| Subjects: | |
| Online Access: | https://phcfm.org/index.php/phcfm/article/view/1901 |
| _version_ | 1819296451301212160 |
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| author | Tshegofatso Mabelane Gboyega A. Ogunbanjo |
| author_facet | Tshegofatso Mabelane Gboyega A. Ogunbanjo |
| author_sort | Tshegofatso Mabelane |
| collection | DOAJ |
| description | Background: An allergic reaction to mammalian meat has recently been reported in rural parts of South Africa and throughout other parts of the world. The cause of this allergic reaction is because of an oligosaccharide antigen known as galactose-alpha-1, 3-galactose (alpha-gal) found in mammalian meat. Hard ticks in various parts of the world have been identified as a cause of sensitisation to the alpha-gal antigen. However, mechanisms of sensitisation in Africa are poorly understood.
Aim: The aim of this article is to review current literature on the alpha-gal allergy and mammalian meat ingestion and the family physician’s role in diagnosing and managing this condition.
Method: Indexes were searched using the keywords in the following electronic databases: Elsevier Science Direct, Google Scholar, Medline and PubMed.
Results: Clinical presentation of the alpha-gal allergy occurs typically as a delayed anaphylaxis occurring within 3–6 hours after the ingestion of mammalian meat. A subset of patients described in South Africa presented with a rapid onset of symptoms occurring within 45 minutes. Furthermore, some of these patients present with abdominal symptoms only, which may be mistaken as food poisoning. Diagnosis is based on a history of reaction to mammalian meats (especially to fatty portions or organs) and serum specific alpha-gal antibodies. The main management of the alpha-gal allergy is avoidance of red meat and in mild reactions treatment with oral H1 receptor antihistamines.
Conclusion: Sensitisation to the alpha-gal allergy results in adverse reactions to red meat, with tolerance to turkey, chicken and fish. A family physician can safely manage this condition. |
| first_indexed | 2024-12-24T04:58:19Z |
| format | Article |
| id | doaj.art-76d667c6dc044498bf9c79077825a948 |
| institution | Directory Open Access Journal |
| issn | 2071-2928 2071-2936 |
| language | English |
| last_indexed | 2024-12-24T04:58:19Z |
| publishDate | 2019-04-01 |
| publisher | AOSIS |
| record_format | Article |
| series | African Journal of Primary Health Care & Family Medicine |
| spelling | doaj.art-76d667c6dc044498bf9c79077825a9482022-12-21T17:14:19ZengAOSISAfrican Journal of Primary Health Care & Family Medicine2071-29282071-29362019-04-01111e1e510.4102/phcfm.v11i1.1901614Ingestion of mammalian meat and alpha-gal allergy: Clinical relevance in primary careTshegofatso Mabelane0Gboyega A. Ogunbanjo1Allergy and Immunology Unit, University of Cape Town, Lung Institute, MowbrayDepartment of Family Medicine and Primary Health Care, Sefako Makgatho Health Sciences University, Ga-RankuwaBackground: An allergic reaction to mammalian meat has recently been reported in rural parts of South Africa and throughout other parts of the world. The cause of this allergic reaction is because of an oligosaccharide antigen known as galactose-alpha-1, 3-galactose (alpha-gal) found in mammalian meat. Hard ticks in various parts of the world have been identified as a cause of sensitisation to the alpha-gal antigen. However, mechanisms of sensitisation in Africa are poorly understood. Aim: The aim of this article is to review current literature on the alpha-gal allergy and mammalian meat ingestion and the family physician’s role in diagnosing and managing this condition. Method: Indexes were searched using the keywords in the following electronic databases: Elsevier Science Direct, Google Scholar, Medline and PubMed. Results: Clinical presentation of the alpha-gal allergy occurs typically as a delayed anaphylaxis occurring within 3–6 hours after the ingestion of mammalian meat. A subset of patients described in South Africa presented with a rapid onset of symptoms occurring within 45 minutes. Furthermore, some of these patients present with abdominal symptoms only, which may be mistaken as food poisoning. Diagnosis is based on a history of reaction to mammalian meats (especially to fatty portions or organs) and serum specific alpha-gal antibodies. The main management of the alpha-gal allergy is avoidance of red meat and in mild reactions treatment with oral H1 receptor antihistamines. Conclusion: Sensitisation to the alpha-gal allergy results in adverse reactions to red meat, with tolerance to turkey, chicken and fish. A family physician can safely manage this condition.https://phcfm.org/index.php/phcfm/article/view/1901alpha-gal allergymammalian meatmanagementprimary carespecific IgE antibodyalpha-gal sensitisation |
| spellingShingle | Tshegofatso Mabelane Gboyega A. Ogunbanjo Ingestion of mammalian meat and alpha-gal allergy: Clinical relevance in primary care African Journal of Primary Health Care & Family Medicine alpha-gal allergy mammalian meat management primary care specific IgE antibody alpha-gal sensitisation |
| title | Ingestion of mammalian meat and alpha-gal allergy: Clinical relevance in primary care |
| title_full | Ingestion of mammalian meat and alpha-gal allergy: Clinical relevance in primary care |
| title_fullStr | Ingestion of mammalian meat and alpha-gal allergy: Clinical relevance in primary care |
| title_full_unstemmed | Ingestion of mammalian meat and alpha-gal allergy: Clinical relevance in primary care |
| title_short | Ingestion of mammalian meat and alpha-gal allergy: Clinical relevance in primary care |
| title_sort | ingestion of mammalian meat and alpha gal allergy clinical relevance in primary care |
| topic | alpha-gal allergy mammalian meat management primary care specific IgE antibody alpha-gal sensitisation |
| url | https://phcfm.org/index.php/phcfm/article/view/1901 |
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