Evaluating Alterations of the Oral Microbiome and Its Link to Oral Cancer among Betel Quid Chewers: Prospecting Reversal through Probiotic Intervention
Areca nut and slaked lime, with or without tobacco wrapped in <i>Piper betle</i> leaf, prepared as betel quid, is extensively consumed as a masticatory product in many countries across the world. Betel Quid can promote the malignant transformation of oral lesions as well as trigger benig...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-07-01
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| Series: | Pathogens |
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| Online Access: | https://www.mdpi.com/2076-0817/12/8/996 |
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| author | Prerna Diwan Mohit Nirwan Mayank Bahuguna Shashi Prabha Kumari James Wahlang Rakesh Kumar Gupta |
| author_facet | Prerna Diwan Mohit Nirwan Mayank Bahuguna Shashi Prabha Kumari James Wahlang Rakesh Kumar Gupta |
| author_sort | Prerna Diwan |
| collection | DOAJ |
| description | Areca nut and slaked lime, with or without tobacco wrapped in <i>Piper betle</i> leaf, prepared as betel quid, is extensively consumed as a masticatory product in many countries across the world. Betel Quid can promote the malignant transformation of oral lesions as well as trigger benign cellular and molecular changes. In the oral cavity, it causes changes at the compositional level in oral microbiota called dysbiosis. This dysbiosis may play an important role in Oral Cancer in betel quid chewers. The abnormal presence and increase of bacteria <i>Fusobacterium nucleatum</i>, <i>Capnocytophaga gingivalis</i>, <i>Prevotella melaninogenica</i>, <i>Peptostreptococcus</i> sp., <i>Porphyromonas gingivalis</i>, and <i>Streptococcus mitis</i> in saliva and/or other oral sites of the cancer patients has attracted frequent attention for its association with oral cancer development. In the present review, the authors have analysed the literature reports to revisit the oncogenic potential of betel quid and oral microbiome alterations, evaluating the potential of oral microbiota both as a driver and biomarker of oral cancer. The authors have also shared a perspective that the restoration of local microbiota can become a potentially therapeutic or prophylactic strategy for the delay or reversal of lip and oral cavity cancers, especially in high-risk population groups. |
| first_indexed | 2024-03-10T23:40:36Z |
| format | Article |
| id | doaj.art-76d85b0a08e84663a5eba72c4d418bf1 |
| institution | Directory Open Access Journal |
| issn | 2076-0817 |
| language | English |
| last_indexed | 2024-03-10T23:40:36Z |
| publishDate | 2023-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pathogens |
| spelling | doaj.art-76d85b0a08e84663a5eba72c4d418bf12023-11-19T02:31:57ZengMDPI AGPathogens2076-08172023-07-0112899610.3390/pathogens12080996Evaluating Alterations of the Oral Microbiome and Its Link to Oral Cancer among Betel Quid Chewers: Prospecting Reversal through Probiotic InterventionPrerna Diwan0Mohit Nirwan1Mayank Bahuguna2Shashi Prabha Kumari3James Wahlang4Rakesh Kumar Gupta5Department of Microbiology, Ram Lal Anand College, University of Delhi, New Delhi 110021, IndiaDepartment of Microbiology, Ram Lal Anand College, University of Delhi, New Delhi 110021, IndiaDepartment of Microbiology, Ram Lal Anand College, University of Delhi, New Delhi 110021, IndiaDepartment of Microbiology, Ram Lal Anand College, University of Delhi, New Delhi 110021, IndiaDepartment of Biochemistry, St. Edmund’s College, Shillong 793003, IndiaDepartment of Microbiology, Ram Lal Anand College, University of Delhi, New Delhi 110021, IndiaAreca nut and slaked lime, with or without tobacco wrapped in <i>Piper betle</i> leaf, prepared as betel quid, is extensively consumed as a masticatory product in many countries across the world. Betel Quid can promote the malignant transformation of oral lesions as well as trigger benign cellular and molecular changes. In the oral cavity, it causes changes at the compositional level in oral microbiota called dysbiosis. This dysbiosis may play an important role in Oral Cancer in betel quid chewers. The abnormal presence and increase of bacteria <i>Fusobacterium nucleatum</i>, <i>Capnocytophaga gingivalis</i>, <i>Prevotella melaninogenica</i>, <i>Peptostreptococcus</i> sp., <i>Porphyromonas gingivalis</i>, and <i>Streptococcus mitis</i> in saliva and/or other oral sites of the cancer patients has attracted frequent attention for its association with oral cancer development. In the present review, the authors have analysed the literature reports to revisit the oncogenic potential of betel quid and oral microbiome alterations, evaluating the potential of oral microbiota both as a driver and biomarker of oral cancer. The authors have also shared a perspective that the restoration of local microbiota can become a potentially therapeutic or prophylactic strategy for the delay or reversal of lip and oral cavity cancers, especially in high-risk population groups.https://www.mdpi.com/2076-0817/12/8/996microbiomeprecancerouslesionsbetel quidarecolineareca nut |
| spellingShingle | Prerna Diwan Mohit Nirwan Mayank Bahuguna Shashi Prabha Kumari James Wahlang Rakesh Kumar Gupta Evaluating Alterations of the Oral Microbiome and Its Link to Oral Cancer among Betel Quid Chewers: Prospecting Reversal through Probiotic Intervention Pathogens microbiome precancerous lesions betel quid arecoline areca nut |
| title | Evaluating Alterations of the Oral Microbiome and Its Link to Oral Cancer among Betel Quid Chewers: Prospecting Reversal through Probiotic Intervention |
| title_full | Evaluating Alterations of the Oral Microbiome and Its Link to Oral Cancer among Betel Quid Chewers: Prospecting Reversal through Probiotic Intervention |
| title_fullStr | Evaluating Alterations of the Oral Microbiome and Its Link to Oral Cancer among Betel Quid Chewers: Prospecting Reversal through Probiotic Intervention |
| title_full_unstemmed | Evaluating Alterations of the Oral Microbiome and Its Link to Oral Cancer among Betel Quid Chewers: Prospecting Reversal through Probiotic Intervention |
| title_short | Evaluating Alterations of the Oral Microbiome and Its Link to Oral Cancer among Betel Quid Chewers: Prospecting Reversal through Probiotic Intervention |
| title_sort | evaluating alterations of the oral microbiome and its link to oral cancer among betel quid chewers prospecting reversal through probiotic intervention |
| topic | microbiome precancerous lesions betel quid arecoline areca nut |
| url | https://www.mdpi.com/2076-0817/12/8/996 |
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