Kinetics of competitive cometabolism under aerobic conditions
Commonly observed competitive substrate inhibition in cometabolism of organic contaminants is used as rate- and reducing-power-determining factors to develop a kinetic model of the competitive cometabolism. Analogous to the well-known theory of Leudeking-Piret kinetics where the product formation de...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2020-01-01
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| Series: | Water-Energy Nexus |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2588912520300217 |
| _version_ | 1819290443305713664 |
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| author | Michael H. Kim Chihhao Fan Shu-Yuan Pan Ingyu Lee YuPo Lin Hyunook Kim |
| author_facet | Michael H. Kim Chihhao Fan Shu-Yuan Pan Ingyu Lee YuPo Lin Hyunook Kim |
| author_sort | Michael H. Kim |
| collection | DOAJ |
| description | Commonly observed competitive substrate inhibition in cometabolism of organic contaminants is used as rate- and reducing-power-determining factors to develop a kinetic model of the competitive cometabolism. Analogous to the well-known theory of Leudeking-Piret kinetics where the product formation demands reducing power, cometabolism is modeled as a reducing power demanding process that also competes with microbial growth for the available reducing power from the degradation of energy-yielding primary substrate. The model further incorporates other growth-associated phenomena such as substrate inhibition and multiple growth/nongrowth substrate interactions that may occur during cometabolic transformation processes. The kinetic model is used successfully to predict a variety of degradation patterns of growth/nongrowth substrates, displayed by microbial cultures when exposed to different concentration ratios of growth to nongrowth substrate: a complete degradation of nongrowth substrates that coincides with the simultaneous depletion of a growth substrate and, in some other cases, an incomplete degradation of a nongrowth substrate following the complete depletion of a growth substrate. These distinct patterns of substrate degradation are attributed to intrinsic specificities of enzymes for cometabolism and lack of reducing power available from the growth substrate degradation. The efficacy of cometabolic capabilities of actively growing microbial cultures and pre-cultured resting cells is discussed in terms of reducing power available in such systems. |
| first_indexed | 2024-12-24T03:22:49Z |
| format | Article |
| id | doaj.art-76d87dc2e7d6430eb2a44102d2cec08a |
| institution | Directory Open Access Journal |
| issn | 2588-9125 |
| language | English |
| last_indexed | 2024-12-24T03:22:49Z |
| publishDate | 2020-01-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Water-Energy Nexus |
| spelling | doaj.art-76d87dc2e7d6430eb2a44102d2cec08a2022-12-21T17:17:26ZengKeAi Communications Co., Ltd.Water-Energy Nexus2588-91252020-01-0136270Kinetics of competitive cometabolism under aerobic conditionsMichael H. Kim0Chihhao Fan1Shu-Yuan Pan2Ingyu Lee3YuPo Lin4Hyunook Kim5Geo-Centers, Inc, PO Box 68, APG, MD 21010, USADepartment of Bioenvironmental Systems Engineering, National Taiwan University, TaiwanDepartment of Bioenvironmental Systems Engineering, National Taiwan University, TaiwanArgonne National Laboratory, Lemont, IL 60439, USAArgonne National Laboratory, Lemont, IL 60439, USADepartment of Environmental Engineering, University of Seoul, South Korea; Corresponding author.Commonly observed competitive substrate inhibition in cometabolism of organic contaminants is used as rate- and reducing-power-determining factors to develop a kinetic model of the competitive cometabolism. Analogous to the well-known theory of Leudeking-Piret kinetics where the product formation demands reducing power, cometabolism is modeled as a reducing power demanding process that also competes with microbial growth for the available reducing power from the degradation of energy-yielding primary substrate. The model further incorporates other growth-associated phenomena such as substrate inhibition and multiple growth/nongrowth substrate interactions that may occur during cometabolic transformation processes. The kinetic model is used successfully to predict a variety of degradation patterns of growth/nongrowth substrates, displayed by microbial cultures when exposed to different concentration ratios of growth to nongrowth substrate: a complete degradation of nongrowth substrates that coincides with the simultaneous depletion of a growth substrate and, in some other cases, an incomplete degradation of a nongrowth substrate following the complete depletion of a growth substrate. These distinct patterns of substrate degradation are attributed to intrinsic specificities of enzymes for cometabolism and lack of reducing power available from the growth substrate degradation. The efficacy of cometabolic capabilities of actively growing microbial cultures and pre-cultured resting cells is discussed in terms of reducing power available in such systems.http://www.sciencedirect.com/science/article/pii/S2588912520300217CometabolismCompetitionReductant supplyOxygenaseKinetic modelSpecificity |
| spellingShingle | Michael H. Kim Chihhao Fan Shu-Yuan Pan Ingyu Lee YuPo Lin Hyunook Kim Kinetics of competitive cometabolism under aerobic conditions Water-Energy Nexus Cometabolism Competition Reductant supply Oxygenase Kinetic model Specificity |
| title | Kinetics of competitive cometabolism under aerobic conditions |
| title_full | Kinetics of competitive cometabolism under aerobic conditions |
| title_fullStr | Kinetics of competitive cometabolism under aerobic conditions |
| title_full_unstemmed | Kinetics of competitive cometabolism under aerobic conditions |
| title_short | Kinetics of competitive cometabolism under aerobic conditions |
| title_sort | kinetics of competitive cometabolism under aerobic conditions |
| topic | Cometabolism Competition Reductant supply Oxygenase Kinetic model Specificity |
| url | http://www.sciencedirect.com/science/article/pii/S2588912520300217 |
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