Insights into Antiviral Properties and Molecular Mechanisms of Non-Flavonoid Polyphenols against Human Herpesviruses
Herpesviruses are one of the most contagious DNA viruses that threaten human health, causing severe diseases, including, but not limited to, certain types of cancer and neurological complications. The overuse and misuse of anti-herpesvirus drugs are key factors leading to drug resistance. Therefore,...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-11-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/22/13891 |
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| author | Sherif T. S. Hassan Miroslava Šudomová Alena Mazurakova Peter Kubatka |
| author_facet | Sherif T. S. Hassan Miroslava Šudomová Alena Mazurakova Peter Kubatka |
| author_sort | Sherif T. S. Hassan |
| collection | DOAJ |
| description | Herpesviruses are one of the most contagious DNA viruses that threaten human health, causing severe diseases, including, but not limited to, certain types of cancer and neurological complications. The overuse and misuse of anti-herpesvirus drugs are key factors leading to drug resistance. Therefore, targeting human herpesviruses with natural products is an attractive form of therapy, as it might improve treatment efficacy in therapy-resistant herpesviruses. Plant polyphenols are major players in the health arena as they possess diverse bioactivities. Hence, in this article, we comprehensively summarize the recent advances that have been attained in employing plant non-flavonoid polyphenols, such as phenolic acids, tannins and their derivatives, stilbenes and their derivatives, lignans, neolignans, xanthones, anthraquinones and their derivatives, curcuminoids, coumarins, furanocoumarins, and other polyphenols (phloroglucinol) as promising anti-herpesvirus drugs against various types of herpesvirus such as alpha-herpesviruses (herpes simplex virus type 1 and 2 and varicella-zoster virus), beta-herpesviruses (human cytomegalovirus), and gamma-herpesviruses (Epstein–Barr virus and Kaposi sarcoma-associated herpesvirus). The molecular mechanisms of non-flavonoid polyphenols against the reviewed herpesviruses are also documented. |
| first_indexed | 2024-03-09T18:17:43Z |
| format | Article |
| id | doaj.art-76db45997cac41b7a4e481e9a06c482a |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T18:17:43Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-76db45997cac41b7a4e481e9a06c482a2023-11-24T08:35:06ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-11-0123221389110.3390/ijms232213891Insights into Antiviral Properties and Molecular Mechanisms of Non-Flavonoid Polyphenols against Human HerpesvirusesSherif T. S. Hassan0Miroslava Šudomová1Alena Mazurakova2Peter Kubatka3Department of Applied Ecology, Faculty of Environmental Sciences, Czech University of Life Sciences Prague, Kamýcká 129, 165 00 Prague, Czech RepublicMuseum of Literature in Moravia, Klášter 1, 664 61 Rajhrad, Czech RepublicDepartment of Medical Biology, Jessenius Faculty of Medicine, Comenius University in Bratislava, 03601 Martin, SlovakiaDepartment of Medical Biology, Jessenius Faculty of Medicine, Comenius University in Bratislava, 03601 Martin, SlovakiaHerpesviruses are one of the most contagious DNA viruses that threaten human health, causing severe diseases, including, but not limited to, certain types of cancer and neurological complications. The overuse and misuse of anti-herpesvirus drugs are key factors leading to drug resistance. Therefore, targeting human herpesviruses with natural products is an attractive form of therapy, as it might improve treatment efficacy in therapy-resistant herpesviruses. Plant polyphenols are major players in the health arena as they possess diverse bioactivities. Hence, in this article, we comprehensively summarize the recent advances that have been attained in employing plant non-flavonoid polyphenols, such as phenolic acids, tannins and their derivatives, stilbenes and their derivatives, lignans, neolignans, xanthones, anthraquinones and their derivatives, curcuminoids, coumarins, furanocoumarins, and other polyphenols (phloroglucinol) as promising anti-herpesvirus drugs against various types of herpesvirus such as alpha-herpesviruses (herpes simplex virus type 1 and 2 and varicella-zoster virus), beta-herpesviruses (human cytomegalovirus), and gamma-herpesviruses (Epstein–Barr virus and Kaposi sarcoma-associated herpesvirus). The molecular mechanisms of non-flavonoid polyphenols against the reviewed herpesviruses are also documented.https://www.mdpi.com/1422-0067/23/22/13891polyphenolsantiviral activityherpes simplex virusHSV-1HSV-2human cytomegalovirus (HCMV) |
| spellingShingle | Sherif T. S. Hassan Miroslava Šudomová Alena Mazurakova Peter Kubatka Insights into Antiviral Properties and Molecular Mechanisms of Non-Flavonoid Polyphenols against Human Herpesviruses International Journal of Molecular Sciences polyphenols antiviral activity herpes simplex virus HSV-1 HSV-2 human cytomegalovirus (HCMV) |
| title | Insights into Antiviral Properties and Molecular Mechanisms of Non-Flavonoid Polyphenols against Human Herpesviruses |
| title_full | Insights into Antiviral Properties and Molecular Mechanisms of Non-Flavonoid Polyphenols against Human Herpesviruses |
| title_fullStr | Insights into Antiviral Properties and Molecular Mechanisms of Non-Flavonoid Polyphenols against Human Herpesviruses |
| title_full_unstemmed | Insights into Antiviral Properties and Molecular Mechanisms of Non-Flavonoid Polyphenols against Human Herpesviruses |
| title_short | Insights into Antiviral Properties and Molecular Mechanisms of Non-Flavonoid Polyphenols against Human Herpesviruses |
| title_sort | insights into antiviral properties and molecular mechanisms of non flavonoid polyphenols against human herpesviruses |
| topic | polyphenols antiviral activity herpes simplex virus HSV-1 HSV-2 human cytomegalovirus (HCMV) |
| url | https://www.mdpi.com/1422-0067/23/22/13891 |
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