Triethylene glycol, an active component of Ashwagandha (Withania somnifera) leaves, is responsible for sleep induction.
Insomnia is the most common sleep complaint which occurs due to difficulty in falling asleep or maintaining it. Most of currently available drugs for insomnia develop dependency and/or adverse effects. Hence natural therapies could be an alternative choice of treatment for insomnia. The root or whol...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2017-01-01
|
| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC5313221?pdf=render |
| _version_ | 1818034502426951680 |
|---|---|
| author | Mahesh K Kaushik Sunil C Kaul Renu Wadhwa Masashi Yanagisawa Yoshihiro Urade |
| author_facet | Mahesh K Kaushik Sunil C Kaul Renu Wadhwa Masashi Yanagisawa Yoshihiro Urade |
| author_sort | Mahesh K Kaushik |
| collection | DOAJ |
| description | Insomnia is the most common sleep complaint which occurs due to difficulty in falling asleep or maintaining it. Most of currently available drugs for insomnia develop dependency and/or adverse effects. Hence natural therapies could be an alternative choice of treatment for insomnia. The root or whole plant extract of Ashwagandha (Withania somnifera) has been used to induce sleep in Indian system of traditional home medicine, Ayurveda. However, its active somnogenic components remain unidentified. We investigated the effect of various components of Ashwagandha leaf on sleep regulation by oral administration in mice. We found that the alcoholic extract that contained high amount of active withanolides was ineffective to induce sleep in mice. However, the water extract which contain triethylene glycol as a major component induced significant amount of non-rapid eye movement sleep with slight change in rapid eye movement sleep. Commercially available triethylene glycol also increased non-rapid eye movement sleep in mice in a dose-dependent (10-30 mg/mouse) manner. These results clearly demonstrated that triethylene glycol is an active sleep-inducing component of Ashwagandha leaves and could potentially be useful for insomnia therapy. |
| first_indexed | 2024-12-10T06:40:11Z |
| format | Article |
| id | doaj.art-76dba463aacf4859ad2aab7f031e678c |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-10T06:40:11Z |
| publishDate | 2017-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-76dba463aacf4859ad2aab7f031e678c2022-12-22T01:58:48ZengPublic Library of Science (PLoS)PLoS ONE1932-62032017-01-01122e017250810.1371/journal.pone.0172508Triethylene glycol, an active component of Ashwagandha (Withania somnifera) leaves, is responsible for sleep induction.Mahesh K KaushikSunil C KaulRenu WadhwaMasashi YanagisawaYoshihiro UradeInsomnia is the most common sleep complaint which occurs due to difficulty in falling asleep or maintaining it. Most of currently available drugs for insomnia develop dependency and/or adverse effects. Hence natural therapies could be an alternative choice of treatment for insomnia. The root or whole plant extract of Ashwagandha (Withania somnifera) has been used to induce sleep in Indian system of traditional home medicine, Ayurveda. However, its active somnogenic components remain unidentified. We investigated the effect of various components of Ashwagandha leaf on sleep regulation by oral administration in mice. We found that the alcoholic extract that contained high amount of active withanolides was ineffective to induce sleep in mice. However, the water extract which contain triethylene glycol as a major component induced significant amount of non-rapid eye movement sleep with slight change in rapid eye movement sleep. Commercially available triethylene glycol also increased non-rapid eye movement sleep in mice in a dose-dependent (10-30 mg/mouse) manner. These results clearly demonstrated that triethylene glycol is an active sleep-inducing component of Ashwagandha leaves and could potentially be useful for insomnia therapy.http://europepmc.org/articles/PMC5313221?pdf=render |
| spellingShingle | Mahesh K Kaushik Sunil C Kaul Renu Wadhwa Masashi Yanagisawa Yoshihiro Urade Triethylene glycol, an active component of Ashwagandha (Withania somnifera) leaves, is responsible for sleep induction. PLoS ONE |
| title | Triethylene glycol, an active component of Ashwagandha (Withania somnifera) leaves, is responsible for sleep induction. |
| title_full | Triethylene glycol, an active component of Ashwagandha (Withania somnifera) leaves, is responsible for sleep induction. |
| title_fullStr | Triethylene glycol, an active component of Ashwagandha (Withania somnifera) leaves, is responsible for sleep induction. |
| title_full_unstemmed | Triethylene glycol, an active component of Ashwagandha (Withania somnifera) leaves, is responsible for sleep induction. |
| title_short | Triethylene glycol, an active component of Ashwagandha (Withania somnifera) leaves, is responsible for sleep induction. |
| title_sort | triethylene glycol an active component of ashwagandha withania somnifera leaves is responsible for sleep induction |
| url | http://europepmc.org/articles/PMC5313221?pdf=render |
| work_keys_str_mv | AT maheshkkaushik triethyleneglycolanactivecomponentofashwagandhawithaniasomniferaleavesisresponsibleforsleepinduction AT sunilckaul triethyleneglycolanactivecomponentofashwagandhawithaniasomniferaleavesisresponsibleforsleepinduction AT renuwadhwa triethyleneglycolanactivecomponentofashwagandhawithaniasomniferaleavesisresponsibleforsleepinduction AT masashiyanagisawa triethyleneglycolanactivecomponentofashwagandhawithaniasomniferaleavesisresponsibleforsleepinduction AT yoshihirourade triethyleneglycolanactivecomponentofashwagandhawithaniasomniferaleavesisresponsibleforsleepinduction |