| Summary: | Background : Results will be presented on a prospective longitudinal study of risk and resilience for post-traumatic stress disorder (PTSD) symptoms in 400 police academy recruits, assessed during academy training and followed during the first 7 years of police service. Methods : Utilizing Latent Growth Mixture Modeling (LGMM) we have established three symptom trajectories, highly resilient, initially distressed with gradual improvement, and increasing distress. Results : We will present findings on the relations of the following predictors ascertained during academy training to the three PTSD symptom trajectories: I.Q., family histories of anxiety, depression, alcohol and drug abuse, neuroticism, personal histories of childhood or adolescent traumatic exposure, levels of awakening cortisol, fear-potentiated acoustic startle, MHPG and cortisol responses to a critical incident video challenge, sleep quality as measured by actigraphy, and candidate polymorphisms including serotonin transporter (SLC6A4), adrenergic pathway genes, ADRB1, ADRB2, ADRA2C, brain derived neurotrophic factor gene (BDNF), genes for several critical components of the hypothalamic–pituitary–adrenal (HPA) axis such as the glucocorticoid receptor (NR3C1), CRH receptor 1 (CRHR1), and FK506 binding protein 5 (FKBP5) and Catechol-O-methyltransferase (COMT). Conclusion : Mulivariate models of risk and resilience will be presented utilizing a multinomial logistic regression nested in the unconditional LGMM.
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