Regenerative Potential of Enamel Matrix Protein Derivative and Acellular Dermal Matrix for Gingival Recession: A Systematic Review and Meta-Analysis
Objective: The purpose of this study was to assess the clinical effectiveness of using a combination of enamel matrix protein derivative and acellular dermal matrix in comparison to acellular dermal matrix alone for treating gingival recessions. Methods: The Cochrane Library (Wiley), PubMed by Medli...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-02-01
|
| Series: | Proteomes |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2227-7382/9/1/11 |
| _version_ | 1797395372570574848 |
|---|---|
| author | Muhammad Saad Shaikh Mohid Abrar Lone Hesham Matabdin Muneeb Ahmed Lone Azeem Hussain Soomro Muhammad Sohail Zafar |
| author_facet | Muhammad Saad Shaikh Mohid Abrar Lone Hesham Matabdin Muneeb Ahmed Lone Azeem Hussain Soomro Muhammad Sohail Zafar |
| author_sort | Muhammad Saad Shaikh |
| collection | DOAJ |
| description | Objective: The purpose of this study was to assess the clinical effectiveness of using a combination of enamel matrix protein derivative and acellular dermal matrix in comparison to acellular dermal matrix alone for treating gingival recessions. Methods: The Cochrane Library (Wiley), PubMed by Medline (NLM), Medline (EBSCO), and Embase (Ovid) databases were searched for entries up to April 2020. Only clinical trials were included. Primary outcomes were root coverage (%), changes in keratinized tissue width and recession (mm). Meta-analysis was conducted for root coverage, changes in keratinized tissue width, recession, clinical attachment level and probing depth. Results: Four studies were selected for the analysis. In primary outcomes, root coverage, change in keratinized tissue width and recession analysis showed a mean difference of 4.99% (<i>p</i> = 0.11), 0.20 mm (<i>p</i> = 0.14) and 0.13 mm (<i>p</i> = 0.23) respectively between the two groups. Secondary outcomes analysis also exhibited a statistically insignificant difference between the test and control group with mean difference of 0.11 mm (<i>p</i> = 0.32) in clinical attachment level gain and -0.03 mm (<i>p</i> = 0.29) in probing depth reduction analysis. Conclusions: Within the limits of this study, enamel matrix protein derivative combined with acellular dermal matrix used for treating gingival recession defects resulted in no beneficial effect clinically than acellular dermal matrix only. |
| first_indexed | 2024-03-09T00:33:30Z |
| format | Article |
| id | doaj.art-76dde641edca4e268ea6d726d6588d8e |
| institution | Directory Open Access Journal |
| issn | 2227-7382 |
| language | English |
| last_indexed | 2024-03-09T00:33:30Z |
| publishDate | 2021-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Proteomes |
| spelling | doaj.art-76dde641edca4e268ea6d726d6588d8e2023-12-11T18:19:55ZengMDPI AGProteomes2227-73822021-02-01911110.3390/proteomes9010011Regenerative Potential of Enamel Matrix Protein Derivative and Acellular Dermal Matrix for Gingival Recession: A Systematic Review and Meta-AnalysisMuhammad Saad Shaikh0Mohid Abrar Lone1Hesham Matabdin2Muneeb Ahmed Lone3Azeem Hussain Soomro4Muhammad Sohail Zafar5Department of Oral Biology, Sindh Institute of Oral Health Sciences, Jinnah Sindh Medical University, Karachi 75510, PakistanDepartment of Oral Pathology, Sindh Institute of Oral Health Sciences, Jinnah Sindh Medical University, Karachi 75510, PakistanDepartment of Periodontics, Eastman Dental Institute, University College London, London WC1E 6BT, UKDepartment of Prosthodontics, Dr. Ishrat-ul-Ebad Khan Institute of Oral Health Sciences, Dow University of Health Sciences, Karachi 74200, PakistanDepartment of Oral Pathology, Dow University of Health Sciences, Karachi 74200, PakistanDepartment of Restorative Dentistry, College of Dentistry, Taibah University, Al Madinah, Al Munawwarah 41311, Saudi ArabiaObjective: The purpose of this study was to assess the clinical effectiveness of using a combination of enamel matrix protein derivative and acellular dermal matrix in comparison to acellular dermal matrix alone for treating gingival recessions. Methods: The Cochrane Library (Wiley), PubMed by Medline (NLM), Medline (EBSCO), and Embase (Ovid) databases were searched for entries up to April 2020. Only clinical trials were included. Primary outcomes were root coverage (%), changes in keratinized tissue width and recession (mm). Meta-analysis was conducted for root coverage, changes in keratinized tissue width, recession, clinical attachment level and probing depth. Results: Four studies were selected for the analysis. In primary outcomes, root coverage, change in keratinized tissue width and recession analysis showed a mean difference of 4.99% (<i>p</i> = 0.11), 0.20 mm (<i>p</i> = 0.14) and 0.13 mm (<i>p</i> = 0.23) respectively between the two groups. Secondary outcomes analysis also exhibited a statistically insignificant difference between the test and control group with mean difference of 0.11 mm (<i>p</i> = 0.32) in clinical attachment level gain and -0.03 mm (<i>p</i> = 0.29) in probing depth reduction analysis. Conclusions: Within the limits of this study, enamel matrix protein derivative combined with acellular dermal matrix used for treating gingival recession defects resulted in no beneficial effect clinically than acellular dermal matrix only.https://www.mdpi.com/2227-7382/9/1/11enamel proteomeacellular dermal matrixalveolar bonesystematic reviewperiodontal regeneration |
| spellingShingle | Muhammad Saad Shaikh Mohid Abrar Lone Hesham Matabdin Muneeb Ahmed Lone Azeem Hussain Soomro Muhammad Sohail Zafar Regenerative Potential of Enamel Matrix Protein Derivative and Acellular Dermal Matrix for Gingival Recession: A Systematic Review and Meta-Analysis Proteomes enamel proteome acellular dermal matrix alveolar bone systematic review periodontal regeneration |
| title | Regenerative Potential of Enamel Matrix Protein Derivative and Acellular Dermal Matrix for Gingival Recession: A Systematic Review and Meta-Analysis |
| title_full | Regenerative Potential of Enamel Matrix Protein Derivative and Acellular Dermal Matrix for Gingival Recession: A Systematic Review and Meta-Analysis |
| title_fullStr | Regenerative Potential of Enamel Matrix Protein Derivative and Acellular Dermal Matrix for Gingival Recession: A Systematic Review and Meta-Analysis |
| title_full_unstemmed | Regenerative Potential of Enamel Matrix Protein Derivative and Acellular Dermal Matrix for Gingival Recession: A Systematic Review and Meta-Analysis |
| title_short | Regenerative Potential of Enamel Matrix Protein Derivative and Acellular Dermal Matrix for Gingival Recession: A Systematic Review and Meta-Analysis |
| title_sort | regenerative potential of enamel matrix protein derivative and acellular dermal matrix for gingival recession a systematic review and meta analysis |
| topic | enamel proteome acellular dermal matrix alveolar bone systematic review periodontal regeneration |
| url | https://www.mdpi.com/2227-7382/9/1/11 |
| work_keys_str_mv | AT muhammadsaadshaikh regenerativepotentialofenamelmatrixproteinderivativeandacellulardermalmatrixforgingivalrecessionasystematicreviewandmetaanalysis AT mohidabrarlone regenerativepotentialofenamelmatrixproteinderivativeandacellulardermalmatrixforgingivalrecessionasystematicreviewandmetaanalysis AT heshammatabdin regenerativepotentialofenamelmatrixproteinderivativeandacellulardermalmatrixforgingivalrecessionasystematicreviewandmetaanalysis AT muneebahmedlone regenerativepotentialofenamelmatrixproteinderivativeandacellulardermalmatrixforgingivalrecessionasystematicreviewandmetaanalysis AT azeemhussainsoomro regenerativepotentialofenamelmatrixproteinderivativeandacellulardermalmatrixforgingivalrecessionasystematicreviewandmetaanalysis AT muhammadsohailzafar regenerativepotentialofenamelmatrixproteinderivativeandacellulardermalmatrixforgingivalrecessionasystematicreviewandmetaanalysis |