Recruitment methods and yield rates for a multisite clinical trial exploring risk reduction for Alzheimer's disease (rrAD)
Abstract INTRODUCTION The risk reduction for Alzheimer's disease (rrAD) trial was a multisite clinical trial to assess exercise and intensive vascular pharmacological treatment on cognitive function in community‐dwelling older adults at increased risk for Alzheimer's disease. METHODS Eligi...
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2023-10-01
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| Series: | Alzheimer’s & Dementia: Translational Research & Clinical Interventions |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/trc2.12422 |
| _version_ | 1827397780056834048 |
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| author | Amanda N. Szabo‐Reed Tristyn Hall Eric D. Vidoni Angela Van Sciver Monica Sewell Jeffrey M. Burns C. Munro Cullum William P. Gahan Linda S. Hynan Diana R. Kerwin Heidi Rossetti Ann M. Stowe Wanpen Vongpatanasin David C. Zhu Rong Zhang Jeffrey N. Keller Ellen F. Binder |
| author_facet | Amanda N. Szabo‐Reed Tristyn Hall Eric D. Vidoni Angela Van Sciver Monica Sewell Jeffrey M. Burns C. Munro Cullum William P. Gahan Linda S. Hynan Diana R. Kerwin Heidi Rossetti Ann M. Stowe Wanpen Vongpatanasin David C. Zhu Rong Zhang Jeffrey N. Keller Ellen F. Binder |
| author_sort | Amanda N. Szabo‐Reed |
| collection | DOAJ |
| description | Abstract INTRODUCTION The risk reduction for Alzheimer's disease (rrAD) trial was a multisite clinical trial to assess exercise and intensive vascular pharmacological treatment on cognitive function in community‐dwelling older adults at increased risk for Alzheimer's disease. METHODS Eligibility, consent, and randomization rates across different referral sources were compared. Informal interviews conducted with each site's project team were conducted upon study completion. RESULTS Initially, 3290 individuals were screened, of whom 28% were eligible to consent, 805 consented to participate (87.2% of those eligible), and 513 (36.3% of those consented) were randomized. Emails sent from study site listservs/databases yielded the highest amount (20.9%) of screened individuals. Professional referrals from physicians yielded the greatest percentage of consented individuals (57.1%). Referrals from non‐professional contacts (ie, friends, family; 75%) and mail/phone contact from a site (73.8%) had the highest yield of randomization. DISCUSSION Professional referrals or email from listservs/registries were most effective for enrolling participants. The greatest yield of eligible/randomized participants came from non‐professional and mail/phone contacts. Future trials should consider special efforts targeting these recruitment approaches. Highlights Clinical trial recruitment is commonly cited as a significant barrier to advancing our understanding of cognitive health interventions. The most cited referral source was email, followed by interviews/editorials on the radio, television, local newspapers, newsletters, or magazine articles. The referral method that brought in the largest number of contacts was email but did not result in the greatest yield of consents or eligible participants. The sources that yielded the greatest likelihood of consent were professional referrals (ie, physician), social media, and mail/phone contact from study site. The greatest yield of eligible/randomized participants came from non‐professional contacts and mail/phone contact from a site. Findings suggest that sites may need to focus on more selective referral sources, such as using contact mailing and phone lists, rather than more widely viewed recruitment sources, such as social media or TV/radio advertisements. |
| first_indexed | 2024-03-08T19:16:33Z |
| format | Article |
| id | doaj.art-76e17e8719694a40a6deed1b1495c499 |
| institution | Directory Open Access Journal |
| issn | 2352-8737 |
| language | English |
| last_indexed | 2024-03-08T19:16:33Z |
| publishDate | 2023-10-01 |
| publisher | Wiley |
| record_format | Article |
| series | Alzheimer’s & Dementia: Translational Research & Clinical Interventions |
| spelling | doaj.art-76e17e8719694a40a6deed1b1495c4992023-12-27T06:47:04ZengWileyAlzheimer’s & Dementia: Translational Research & Clinical Interventions2352-87372023-10-0194n/an/a10.1002/trc2.12422Recruitment methods and yield rates for a multisite clinical trial exploring risk reduction for Alzheimer's disease (rrAD)Amanda N. Szabo‐Reed0Tristyn Hall1Eric D. Vidoni2Angela Van Sciver3Monica Sewell4Jeffrey M. Burns5C. Munro Cullum6William P. Gahan7Linda S. Hynan8Diana R. Kerwin9Heidi Rossetti10Ann M. Stowe11Wanpen Vongpatanasin12David C. Zhu13Rong Zhang14Jeffrey N. Keller15Ellen F. Binder16KU Alzheimer's Disease Research Center, University of Kansas Medical CenterFairwayKansasUSAInstitute for Exercise and Environmental Medicine Texas Health Presbyterian Hospital Dallas Dallas USAKU Alzheimer's Disease Research Center, University of Kansas Medical CenterFairwayKansasUSAKU Alzheimer's Disease Research Center, University of Kansas Medical CenterFairwayKansasUSADepartment of Internal Medicine Division of Geriatrics & Nutritional Science Washington University School of Medicine in St. Louis St. Louis Missouri USAKU Alzheimer's Disease Research Center, University of Kansas Medical CenterFairwayKansasUSADepartment of Psychiatry UT Southwestern Medical Center Dallas Texas USAInstitute for Dementia Research and Prevention Pennington Biomedical Research Center Baton Rouge Louisiana USADepartment of Psychiatry UT Southwestern Medical Center Dallas Texas USAKerwin Research Center and Memory Care Dallas Texas USADepartment of Psychiatry UT Southwestern Medical Center Dallas Texas USADepartment of Neurology University of Kentucky Lexington Kentucky USAInstitute for Dementia Research and Prevention Pennington Biomedical Research Center Baton Rouge Louisiana USADepartment for Radiology Michigan State University East Lansing Michigan USAInstitute for Exercise and Environmental Medicine Texas Health Presbyterian Hospital Dallas Dallas USAInstitute for Dementia Research and Prevention Pennington Biomedical Research Center Baton Rouge Louisiana USADepartment of Internal Medicine Division of Geriatrics & Nutritional Science Washington University School of Medicine in St. Louis St. Louis Missouri USAAbstract INTRODUCTION The risk reduction for Alzheimer's disease (rrAD) trial was a multisite clinical trial to assess exercise and intensive vascular pharmacological treatment on cognitive function in community‐dwelling older adults at increased risk for Alzheimer's disease. METHODS Eligibility, consent, and randomization rates across different referral sources were compared. Informal interviews conducted with each site's project team were conducted upon study completion. RESULTS Initially, 3290 individuals were screened, of whom 28% were eligible to consent, 805 consented to participate (87.2% of those eligible), and 513 (36.3% of those consented) were randomized. Emails sent from study site listservs/databases yielded the highest amount (20.9%) of screened individuals. Professional referrals from physicians yielded the greatest percentage of consented individuals (57.1%). Referrals from non‐professional contacts (ie, friends, family; 75%) and mail/phone contact from a site (73.8%) had the highest yield of randomization. DISCUSSION Professional referrals or email from listservs/registries were most effective for enrolling participants. The greatest yield of eligible/randomized participants came from non‐professional and mail/phone contacts. Future trials should consider special efforts targeting these recruitment approaches. Highlights Clinical trial recruitment is commonly cited as a significant barrier to advancing our understanding of cognitive health interventions. The most cited referral source was email, followed by interviews/editorials on the radio, television, local newspapers, newsletters, or magazine articles. The referral method that brought in the largest number of contacts was email but did not result in the greatest yield of consents or eligible participants. The sources that yielded the greatest likelihood of consent were professional referrals (ie, physician), social media, and mail/phone contact from study site. The greatest yield of eligible/randomized participants came from non‐professional contacts and mail/phone contact from a site. Findings suggest that sites may need to focus on more selective referral sources, such as using contact mailing and phone lists, rather than more widely viewed recruitment sources, such as social media or TV/radio advertisements.https://doi.org/10.1002/trc2.12422Alzheimer's diseasebrain structurecognitionexerciserecruitmentreduction of vascular risk factors |
| spellingShingle | Amanda N. Szabo‐Reed Tristyn Hall Eric D. Vidoni Angela Van Sciver Monica Sewell Jeffrey M. Burns C. Munro Cullum William P. Gahan Linda S. Hynan Diana R. Kerwin Heidi Rossetti Ann M. Stowe Wanpen Vongpatanasin David C. Zhu Rong Zhang Jeffrey N. Keller Ellen F. Binder Recruitment methods and yield rates for a multisite clinical trial exploring risk reduction for Alzheimer's disease (rrAD) Alzheimer’s & Dementia: Translational Research & Clinical Interventions Alzheimer's disease brain structure cognition exercise recruitment reduction of vascular risk factors |
| title | Recruitment methods and yield rates for a multisite clinical trial exploring risk reduction for Alzheimer's disease (rrAD) |
| title_full | Recruitment methods and yield rates for a multisite clinical trial exploring risk reduction for Alzheimer's disease (rrAD) |
| title_fullStr | Recruitment methods and yield rates for a multisite clinical trial exploring risk reduction for Alzheimer's disease (rrAD) |
| title_full_unstemmed | Recruitment methods and yield rates for a multisite clinical trial exploring risk reduction for Alzheimer's disease (rrAD) |
| title_short | Recruitment methods and yield rates for a multisite clinical trial exploring risk reduction for Alzheimer's disease (rrAD) |
| title_sort | recruitment methods and yield rates for a multisite clinical trial exploring risk reduction for alzheimer s disease rrad |
| topic | Alzheimer's disease brain structure cognition exercise recruitment reduction of vascular risk factors |
| url | https://doi.org/10.1002/trc2.12422 |
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