SGLT2-Inhibitors and Euglycemia Diabetic Ketoacidosis: A Missed Diagnosis
Euglycemic diabetic ketoacidosis (EuDKA), is an uncommon but potentially fatal medical emergency characterized by metabolic acidosis, ketosis, and either normal or near normal blood glucose level. The Diagnosis is delayed due to a lack of hyperglycemia leading to adverse consequences. It’s not a r...
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| Format: | Article |
| Language: | English |
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Liaquat National Hospital and Medical College
2023-12-01
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| Series: | Liaquat National Journal of Primary Care |
| Subjects: | |
| Online Access: | https://journals.lnh.edu.pk/lnjpc/pdf/8e9ad2b0-050d-4d05-bee1-f5241bcc32fa.pdf |
| _version_ | 1797745906100994048 |
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| author | Muhammad Nadeem Ahmed Khan Sana Jabeen |
| author_facet | Muhammad Nadeem Ahmed Khan Sana Jabeen |
| author_sort | Muhammad Nadeem Ahmed Khan |
| collection | DOAJ |
| description | Euglycemic diabetic ketoacidosis (EuDKA), is an uncommon but potentially fatal medical emergency characterized by metabolic
acidosis, ketosis, and either normal or near normal blood glucose level. The Diagnosis is delayed due to a lack of hyperglycemia
leading to adverse consequences. It’s not a routine diagnosis but patients with both types of diabetes mellitus may suffer from it. Since
august 2014, after the inclusion of sodium-glucose cotransporter-2 inhibitors (SGLT2i) for the management of diabetes mellitus, the
incidence of euglycemia DKA has raised. The other conditions that may contribute to this metabolic disorder include fasting, chronic
liver disease, pregnancy, gastroparesis, bariatric surgery, glycogen storage disease, cocaine intoxication, and insulin pump failure.
Euglycemic DKA, a diagnosis of exclusion, should be considered in any unexplained metabolic acidosis among diabetic patients,
who report to the hospital with nonspecific symptoms not suggesting DKA and have been taking sodium-glucose cotransporter-2
inhibitors. Here we are describing a case of ketoacidosis with normoglycemia caused by empagliflozin in a female suffering from
type 2 diabetes mellitus to raise awareness of physicians to minimize the delays in the identification of this life-threatening metabolic
disorder. |
| first_indexed | 2024-03-12T15:30:34Z |
| format | Article |
| id | doaj.art-76e2fae49b4845bfab7dfed9b62abe41 |
| institution | Directory Open Access Journal |
| issn | 2707-3521 2708-9134 |
| language | English |
| last_indexed | 2024-03-12T15:30:34Z |
| publishDate | 2023-12-01 |
| publisher | Liaquat National Hospital and Medical College |
| record_format | Article |
| series | Liaquat National Journal of Primary Care |
| spelling | doaj.art-76e2fae49b4845bfab7dfed9b62abe412023-08-10T06:54:22ZengLiaquat National Hospital and Medical CollegeLiaquat National Journal of Primary Care2707-35212708-91342023-12-015320720910.37184/lnjpc.2707-3521.5.28SGLT2-Inhibitors and Euglycemia Diabetic Ketoacidosis: A Missed DiagnosisMuhammad Nadeem Ahmed Khan0Sana Jabeen1Department of Medicine, PNS Rahat Hospital, Karachi, PakistanDepartment of Medicine, Memon Medical Institute, Karachi, PakistanEuglycemic diabetic ketoacidosis (EuDKA), is an uncommon but potentially fatal medical emergency characterized by metabolic acidosis, ketosis, and either normal or near normal blood glucose level. The Diagnosis is delayed due to a lack of hyperglycemia leading to adverse consequences. It’s not a routine diagnosis but patients with both types of diabetes mellitus may suffer from it. Since august 2014, after the inclusion of sodium-glucose cotransporter-2 inhibitors (SGLT2i) for the management of diabetes mellitus, the incidence of euglycemia DKA has raised. The other conditions that may contribute to this metabolic disorder include fasting, chronic liver disease, pregnancy, gastroparesis, bariatric surgery, glycogen storage disease, cocaine intoxication, and insulin pump failure. Euglycemic DKA, a diagnosis of exclusion, should be considered in any unexplained metabolic acidosis among diabetic patients, who report to the hospital with nonspecific symptoms not suggesting DKA and have been taking sodium-glucose cotransporter-2 inhibitors. Here we are describing a case of ketoacidosis with normoglycemia caused by empagliflozin in a female suffering from type 2 diabetes mellitus to raise awareness of physicians to minimize the delays in the identification of this life-threatening metabolic disorder.https://journals.lnh.edu.pk/lnjpc/pdf/8e9ad2b0-050d-4d05-bee1-f5241bcc32fa.pdfmetabolic acidosishyperglycemiadiabetes mellitussodium-glucose cotransporter-2 inhibitorsempagliflozin. |
| spellingShingle | Muhammad Nadeem Ahmed Khan Sana Jabeen SGLT2-Inhibitors and Euglycemia Diabetic Ketoacidosis: A Missed Diagnosis Liaquat National Journal of Primary Care metabolic acidosis hyperglycemia diabetes mellitus sodium-glucose cotransporter-2 inhibitors empagliflozin. |
| title | SGLT2-Inhibitors and Euglycemia Diabetic Ketoacidosis: A Missed Diagnosis |
| title_full | SGLT2-Inhibitors and Euglycemia Diabetic Ketoacidosis: A Missed Diagnosis |
| title_fullStr | SGLT2-Inhibitors and Euglycemia Diabetic Ketoacidosis: A Missed Diagnosis |
| title_full_unstemmed | SGLT2-Inhibitors and Euglycemia Diabetic Ketoacidosis: A Missed Diagnosis |
| title_short | SGLT2-Inhibitors and Euglycemia Diabetic Ketoacidosis: A Missed Diagnosis |
| title_sort | sglt2 inhibitors and euglycemia diabetic ketoacidosis a missed diagnosis |
| topic | metabolic acidosis hyperglycemia diabetes mellitus sodium-glucose cotransporter-2 inhibitors empagliflozin. |
| url | https://journals.lnh.edu.pk/lnjpc/pdf/8e9ad2b0-050d-4d05-bee1-f5241bcc32fa.pdf |
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