Triglyceride glucose-body mass index and the risk of progression to diabetes from prediabetes: A 5-year cohort study in Chinese adults
ObjectiveEvidence regarding the relationship between the triglyceride glucose-body mass index (TyG-BMI) and the risk of progression from prediabetes to diabetes remains limited. Our study aimed to investigate the relationship between them in patients with prediabetes.MethodsIn this retrospective coh...
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| Format: | Article |
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Frontiers Media S.A.
2023-02-01
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| Series: | Frontiers in Public Health |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpubh.2023.1028461/full |
| _version_ | 1811173355520262144 |
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| author | Yong Han Haofei Hu Qiming Li Zhe Deng Dehong Liu |
| author_facet | Yong Han Haofei Hu Qiming Li Zhe Deng Dehong Liu |
| author_sort | Yong Han |
| collection | DOAJ |
| description | ObjectiveEvidence regarding the relationship between the triglyceride glucose-body mass index (TyG-BMI) and the risk of progression from prediabetes to diabetes remains limited. Our study aimed to investigate the relationship between them in patients with prediabetes.MethodsIn this retrospective cohort study, data were collected from 25,279 patients with prediabetes who received health checks between 2010 and 2016. We used a Cox proportional-hazards regression model to examine the relationship between TyG-BMI and diabetes risk. We used Cox proportional hazards regression with cubic spline functions and smooth curve fitting to identify the nonlinear relationship between them. In addition, A series of sensitivity and subgroup analyses were also conducted.ResultsThe mean age of the included participants was 49.29 ± 13.82 years old, and 1,6734 (66.2%) were male. The mean TyG-BMI was 219.47. The median follow-up time was 2.89 years, and 2,687 (10.63%) individuals had a final diagnosis of diabetes. After adjusting for covariates, TyG-BMI was positively linked with incident diabetes in patients with prediabetes (HR = 1.011, 95%CI 1.010–1.012). TyG-BMI had a non-linear connection with diabetes risk, and its inflection point was 231.66. Right and left effects sizes (HR) at the inflection point were 1.017 (95%CI:1.014–1.019) and 1.007 (95%CI:1.005–1.009), respectively. The sensitivity analysis demonstrated the robustness of these results.ConclusionThis study demonstrated a positive, non-linear relationship between the TyG-BMI and diabetes risk in Chinese patients with prediabetes. When the TyG-BMI was <231.66, there was a significant positive association between TyG-BMI and the risk of progression from prediabetes to diabetes. This study serves as a reference to promote clinical consultation and optimize diabetes prevention decisions for patients with prediabetes. |
| first_indexed | 2024-04-10T17:45:27Z |
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| id | doaj.art-76e301f1aa7945a6b02a2de478b792df |
| institution | Directory Open Access Journal |
| issn | 2296-2565 |
| language | English |
| last_indexed | 2024-04-10T17:45:27Z |
| publishDate | 2023-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Public Health |
| spelling | doaj.art-76e301f1aa7945a6b02a2de478b792df2023-02-03T04:59:38ZengFrontiers Media S.A.Frontiers in Public Health2296-25652023-02-011110.3389/fpubh.2023.10284611028461Triglyceride glucose-body mass index and the risk of progression to diabetes from prediabetes: A 5-year cohort study in Chinese adultsYong Han0Haofei Hu1Qiming Li2Zhe Deng3Dehong Liu4Department of Emergency, Shenzhen Second People's Hospital, Shenzhen, Guangdong, ChinaDepartment of Nephrology, Shenzhen Second People's Hospital, Shenzhen, Guangdong, ChinaDepartment of Emergency, Shenzhen Second People's Hospital, Shenzhen, Guangdong, ChinaDepartment of Emergency, Shenzhen Second People's Hospital, Shenzhen, Guangdong, ChinaDepartment of Emergency, Shenzhen Second People's Hospital, Shenzhen, Guangdong, ChinaObjectiveEvidence regarding the relationship between the triglyceride glucose-body mass index (TyG-BMI) and the risk of progression from prediabetes to diabetes remains limited. Our study aimed to investigate the relationship between them in patients with prediabetes.MethodsIn this retrospective cohort study, data were collected from 25,279 patients with prediabetes who received health checks between 2010 and 2016. We used a Cox proportional-hazards regression model to examine the relationship between TyG-BMI and diabetes risk. We used Cox proportional hazards regression with cubic spline functions and smooth curve fitting to identify the nonlinear relationship between them. In addition, A series of sensitivity and subgroup analyses were also conducted.ResultsThe mean age of the included participants was 49.29 ± 13.82 years old, and 1,6734 (66.2%) were male. The mean TyG-BMI was 219.47. The median follow-up time was 2.89 years, and 2,687 (10.63%) individuals had a final diagnosis of diabetes. After adjusting for covariates, TyG-BMI was positively linked with incident diabetes in patients with prediabetes (HR = 1.011, 95%CI 1.010–1.012). TyG-BMI had a non-linear connection with diabetes risk, and its inflection point was 231.66. Right and left effects sizes (HR) at the inflection point were 1.017 (95%CI:1.014–1.019) and 1.007 (95%CI:1.005–1.009), respectively. The sensitivity analysis demonstrated the robustness of these results.ConclusionThis study demonstrated a positive, non-linear relationship between the TyG-BMI and diabetes risk in Chinese patients with prediabetes. When the TyG-BMI was <231.66, there was a significant positive association between TyG-BMI and the risk of progression from prediabetes to diabetes. This study serves as a reference to promote clinical consultation and optimize diabetes prevention decisions for patients with prediabetes.https://www.frontiersin.org/articles/10.3389/fpubh.2023.1028461/fulltriglyceride-glucose indexprediabetesdiabetessmooth curve fittingnon-linear relationship |
| spellingShingle | Yong Han Haofei Hu Qiming Li Zhe Deng Dehong Liu Triglyceride glucose-body mass index and the risk of progression to diabetes from prediabetes: A 5-year cohort study in Chinese adults Frontiers in Public Health triglyceride-glucose index prediabetes diabetes smooth curve fitting non-linear relationship |
| title | Triglyceride glucose-body mass index and the risk of progression to diabetes from prediabetes: A 5-year cohort study in Chinese adults |
| title_full | Triglyceride glucose-body mass index and the risk of progression to diabetes from prediabetes: A 5-year cohort study in Chinese adults |
| title_fullStr | Triglyceride glucose-body mass index and the risk of progression to diabetes from prediabetes: A 5-year cohort study in Chinese adults |
| title_full_unstemmed | Triglyceride glucose-body mass index and the risk of progression to diabetes from prediabetes: A 5-year cohort study in Chinese adults |
| title_short | Triglyceride glucose-body mass index and the risk of progression to diabetes from prediabetes: A 5-year cohort study in Chinese adults |
| title_sort | triglyceride glucose body mass index and the risk of progression to diabetes from prediabetes a 5 year cohort study in chinese adults |
| topic | triglyceride-glucose index prediabetes diabetes smooth curve fitting non-linear relationship |
| url | https://www.frontiersin.org/articles/10.3389/fpubh.2023.1028461/full |
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