Tethered Aryl Groups Increase the Activity of Anti-Proliferative Thieno[2,3-<i>b</i>]Pyridines by Targeting a Lipophilic Region in the Active Site of PI-PLC

Tethered Aryl Groups Increase the Activity of Anti-Proliferative Thieno[2,3-<i>b</i>]Pyridines by Targeting a Lipophilic Region in the Active Site of PI-PLC

The compounds 2-amino-3-carboxamido-thieno[2,3-<i>b</i>]pyridines have demonstrated excellent anti-proliferative activity against human cancer cell lines, including the triple-negative breast cancer cell line MDA-MB-231. In this study, 81 novel thieno[2,3-<i>b</i>]pyridines w...

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Bibliographic Details
Main Authors:	Natalie A. Haverkate, Euphemia Leung, Lisa I. Pilkington, David Barker
Format:	Article
Language:	English
Published:	MDPI AG 2021-11-01
Series:	Pharmaceutics
Subjects:	thieno[2,3-<i>b</i>]pyridines anti-proliferative α,β-unsaturated ketones heterocycles
Online Access:	https://www.mdpi.com/1999-4923/13/12/2020

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