Validation of circulating histone detection by mass spectrometry for early diagnosis, prognosis, and management of critically ill septic patients

Validation of circulating histone detection by mass spectrometry for early diagnosis, prognosis, and management of critically ill septic patients

Abstract Background As leading contributors to worldwide morbidity and mortality, sepsis and septic shock are considered a major global health concern. Proactive biomarker identification in patients with sepsis suspicion at any time remains a daunting challenge for hospitals. Despite great progress...

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Main Authors: José Luis García-Giménez, Eva García-López, Salvador Mena-Mollá, Jesús Beltrán-García, Rebeca Osca-Verdegal, Elena Nacher-Sendra, Carmen Aguado-Velasco, Germán Casabó-Vallés, Carlos Romá-Mateo, María Rodriguez-Gimillo, Oreto Antúnez, José Ferreres, Federico V. Pallardó, Nieves Carbonell
Format: Article
Language:English
Published: BMC 2023-05-01
Series:Journal of Translational Medicine
Subjects:
Histones
Mass spectrometry
Sepsis
Septic shock
Disseminated intravascular coagulation
Diagnosis
Online Access:https://doi.org/10.1186/s12967-023-04197-1

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