Morphology and pathogenesis of white matter changes in chronic cerebrovascular disease
This review contains up-to-date information on the fundamentals and clinical aspects of white matter disease in chronic progressive cerebrovascular disease with cognitive impairment, the leading risk factors for which are hypertension and cerebral atherosclerosis. Highly informative methods of neuro...
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| Format: | Article |
| Language: | English |
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Research Center of Neurology
2022-06-01
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| Series: | Анналы клинической и экспериментальной неврологии |
| Subjects: | |
| Online Access: | https://annaly-nevrologii.com/journal/pathID/article/viewFile/827/pdf |
| _version_ | 1818180550351912960 |
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| author | Tatyana S. Gulevskaya Pavel L. Anufriev Мarine М. Tanashyan |
| author_facet | Tatyana S. Gulevskaya Pavel L. Anufriev Мarine М. Tanashyan |
| author_sort | Tatyana S. Gulevskaya |
| collection | DOAJ |
| description | This review contains up-to-date information on the fundamentals and clinical aspects of white matter disease in chronic progressive cerebrovascular disease with cognitive impairment, the leading risk factors for which are hypertension and cerebral atherosclerosis. Highly informative methods of neuroimaging have contributed significantly to the study of this problem, confirming the important role of white matter changes in the development and progression of cognitive impairment. The full range of the morphological changes in white matter, typical of vascular encephalopathy and cognitive dysfunction, is presented. Chronic hypoperfusion and white matter ischaemia play a leading role in the pathogenesis of white matter changes in vascular dementia development, but alternative hypotheses are also emerging. Further fundamental morphological and clinical studies will help to determine the leading mechanisms of white matter damage in patients with vascular and other age-related forms of dementia. This is necessary for the development of effective methods of treatment and prevention. |
| first_indexed | 2024-12-11T21:21:33Z |
| format | Article |
| id | doaj.art-76e3ef5b1526419ca573c1a561d4c639 |
| institution | Directory Open Access Journal |
| issn | 2075-5473 2409-2533 |
| language | English |
| last_indexed | 2024-12-11T21:21:33Z |
| publishDate | 2022-06-01 |
| publisher | Research Center of Neurology |
| record_format | Article |
| series | Анналы клинической и экспериментальной неврологии |
| spelling | doaj.art-76e3ef5b1526419ca573c1a561d4c6392022-12-22T00:50:28ZengResearch Center of NeurologyАнналы клинической и экспериментальной неврологии2075-54732409-25332022-06-01162788810.54101/ACEN.2022.2.9598Morphology and pathogenesis of white matter changes in chronic cerebrovascular diseaseTatyana S. Gulevskaya0https://orcid.org/0000-0003-2970-8136Pavel L. Anufriev1https://orcid.org/0000-0002-5327-2275Мarine М. Tanashyan2https://orcid.org/0000-0002-5883-8119Research Center of NeurologyResearch Center of NeurologyResearch Center of NeurologyThis review contains up-to-date information on the fundamentals and clinical aspects of white matter disease in chronic progressive cerebrovascular disease with cognitive impairment, the leading risk factors for which are hypertension and cerebral atherosclerosis. Highly informative methods of neuroimaging have contributed significantly to the study of this problem, confirming the important role of white matter changes in the development and progression of cognitive impairment. The full range of the morphological changes in white matter, typical of vascular encephalopathy and cognitive dysfunction, is presented. Chronic hypoperfusion and white matter ischaemia play a leading role in the pathogenesis of white matter changes in vascular dementia development, but alternative hypotheses are also emerging. Further fundamental morphological and clinical studies will help to determine the leading mechanisms of white matter damage in patients with vascular and other age-related forms of dementia. This is necessary for the development of effective methods of treatment and prevention.https://annaly-nevrologii.com/journal/pathID/article/viewFile/827/pdfwhite matter diseasehypertensioncerebral atherosclerosiswhite matter hyperintensitycognitive impairmentbinswanger's disease |
| spellingShingle | Tatyana S. Gulevskaya Pavel L. Anufriev Мarine М. Tanashyan Morphology and pathogenesis of white matter changes in chronic cerebrovascular disease Анналы клинической и экспериментальной неврологии white matter disease hypertension cerebral atherosclerosis white matter hyperintensity cognitive impairment binswanger's disease |
| title | Morphology and pathogenesis of white matter changes in chronic cerebrovascular disease |
| title_full | Morphology and pathogenesis of white matter changes in chronic cerebrovascular disease |
| title_fullStr | Morphology and pathogenesis of white matter changes in chronic cerebrovascular disease |
| title_full_unstemmed | Morphology and pathogenesis of white matter changes in chronic cerebrovascular disease |
| title_short | Morphology and pathogenesis of white matter changes in chronic cerebrovascular disease |
| title_sort | morphology and pathogenesis of white matter changes in chronic cerebrovascular disease |
| topic | white matter disease hypertension cerebral atherosclerosis white matter hyperintensity cognitive impairment binswanger's disease |
| url | https://annaly-nevrologii.com/journal/pathID/article/viewFile/827/pdf |
| work_keys_str_mv | AT tatyanasgulevskaya morphologyandpathogenesisofwhitematterchangesinchroniccerebrovasculardisease AT pavellanufriev morphologyandpathogenesisofwhitematterchangesinchroniccerebrovasculardisease AT marinemtanashyan morphologyandpathogenesisofwhitematterchangesinchroniccerebrovasculardisease |