Greater alteration of gut microbiota occurs in childhood obesity than in adulthood obesity
The children's gut microbiota, associated with the development of obesity, is in maturation. The impact of obesity on the gut microbiota in childhood could have a more significant effect than on adulthood and eventually be lifelong lasting, but it has been rarely studied. Aimed to discover the...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-01-01
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| Series: | Frontiers in Pediatrics |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fped.2023.1087401/full |
| _version_ | 1797942728932196352 |
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| author | Zhongjia Yu Xiang-Fang Yu Xiang-Fang Yu Xiu Zhao Zhe Su Pei-Gen Ren Pei-Gen Ren |
| author_facet | Zhongjia Yu Xiang-Fang Yu Xiang-Fang Yu Xiu Zhao Zhe Su Pei-Gen Ren Pei-Gen Ren |
| author_sort | Zhongjia Yu |
| collection | DOAJ |
| description | The children's gut microbiota, associated with the development of obesity, is in maturation. The impact of obesity on the gut microbiota in childhood could have a more significant effect than on adulthood and eventually be lifelong lasting, but it has been rarely studied. Aimed to discover the difference in gut microbiota between children and adults with obesity, we collected published amplicon sequencing data from National Center for Biotechnology Information (NCBI) and re-analyzed them using a uniform bioinformatic pipeline, as well as predicted the obesity using gut microbiota based on the random forest model. Summarizing common points among these cohorts, we found that the gut microbiota had a significant difference between children with and without obesity, but this difference was not observed in adult cohorts. Based on the random forest model, it was more challenging to predict childhood obesity using gut microbiota than adulthood obesity. Our results suggest that gut microbiota in childhood is more easily affected than in adulthood. Early intervention for childhood obesity is essential to improve children's health and lifelong gut microbiota-related health. |
| first_indexed | 2024-04-10T20:12:26Z |
| format | Article |
| id | doaj.art-76e42a9ad96d4848a1bb1782f23063dd |
| institution | Directory Open Access Journal |
| issn | 2296-2360 |
| language | English |
| last_indexed | 2024-04-10T20:12:26Z |
| publishDate | 2023-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pediatrics |
| spelling | doaj.art-76e42a9ad96d4848a1bb1782f23063dd2023-01-26T09:36:40ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602023-01-011110.3389/fped.2023.10874011087401Greater alteration of gut microbiota occurs in childhood obesity than in adulthood obesityZhongjia Yu0Xiang-Fang Yu1Xiang-Fang Yu2Xiu Zhao3Zhe Su4Pei-Gen Ren5Pei-Gen Ren6Center for Energy Metabolism and Reproduction, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, ChinaCenter for Energy Metabolism and Reproduction, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, ChinaShenzhen College of Advanced Technology, University of Chinese Academy of Sciences, Shenzhen, ChinaDepartment of Endocrinology, Shenzhen Children's Hospital, Shenzhen, ChinaDepartment of Endocrinology, Shenzhen Children's Hospital, Shenzhen, ChinaCenter for Energy Metabolism and Reproduction, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, ChinaShenzhen College of Advanced Technology, University of Chinese Academy of Sciences, Shenzhen, ChinaThe children's gut microbiota, associated with the development of obesity, is in maturation. The impact of obesity on the gut microbiota in childhood could have a more significant effect than on adulthood and eventually be lifelong lasting, but it has been rarely studied. Aimed to discover the difference in gut microbiota between children and adults with obesity, we collected published amplicon sequencing data from National Center for Biotechnology Information (NCBI) and re-analyzed them using a uniform bioinformatic pipeline, as well as predicted the obesity using gut microbiota based on the random forest model. Summarizing common points among these cohorts, we found that the gut microbiota had a significant difference between children with and without obesity, but this difference was not observed in adult cohorts. Based on the random forest model, it was more challenging to predict childhood obesity using gut microbiota than adulthood obesity. Our results suggest that gut microbiota in childhood is more easily affected than in adulthood. Early intervention for childhood obesity is essential to improve children's health and lifelong gut microbiota-related health.https://www.frontiersin.org/articles/10.3389/fped.2023.1087401/fullchildrenadultsgut microbiotaobesitydata mining |
| spellingShingle | Zhongjia Yu Xiang-Fang Yu Xiang-Fang Yu Xiu Zhao Zhe Su Pei-Gen Ren Pei-Gen Ren Greater alteration of gut microbiota occurs in childhood obesity than in adulthood obesity Frontiers in Pediatrics children adults gut microbiota obesity data mining |
| title | Greater alteration of gut microbiota occurs in childhood obesity than in adulthood obesity |
| title_full | Greater alteration of gut microbiota occurs in childhood obesity than in adulthood obesity |
| title_fullStr | Greater alteration of gut microbiota occurs in childhood obesity than in adulthood obesity |
| title_full_unstemmed | Greater alteration of gut microbiota occurs in childhood obesity than in adulthood obesity |
| title_short | Greater alteration of gut microbiota occurs in childhood obesity than in adulthood obesity |
| title_sort | greater alteration of gut microbiota occurs in childhood obesity than in adulthood obesity |
| topic | children adults gut microbiota obesity data mining |
| url | https://www.frontiersin.org/articles/10.3389/fped.2023.1087401/full |
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