Linking Adiposity to Interstitial Lung Disease: The Role of the Dysfunctional Adipocyte and Inflammation
Adipose tissue has functions beyond its principal functions in energy storage, including endocrine and immune functions. When faced with a surplus of energy, the functions of adipose tissue expand by mechanisms that can be both adaptive and detrimental. These detrimental adipose tissue functions can...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-09-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/12/18/2206 |
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| author | Michael Macklin Chelsea Thompson Leticia Kawano-Dourado Iazsmin Bauer Ventura Camila Weschenfelder Andrés Trostchansky Aline Marcadenti Robert M. Tighe |
| author_facet | Michael Macklin Chelsea Thompson Leticia Kawano-Dourado Iazsmin Bauer Ventura Camila Weschenfelder Andrés Trostchansky Aline Marcadenti Robert M. Tighe |
| author_sort | Michael Macklin |
| collection | DOAJ |
| description | Adipose tissue has functions beyond its principal functions in energy storage, including endocrine and immune functions. When faced with a surplus of energy, the functions of adipose tissue expand by mechanisms that can be both adaptive and detrimental. These detrimental adipose tissue functions can alter normal hormonal signaling and promote local and systemic inflammation with wide-ranging consequences. Although the mechanisms by which adipose tissue triggers metabolic dysfunction and local inflammation have been well described, little is known about the relationship between adiposity and the pathogenesis of chronic lung conditions, such as interstitial lung disease (ILD). In this review, we detail the conditions and mechanisms by which adipose tissue becomes dysfunctional and relate this dysfunction to inflammatory changes observed in various forms of ILD. Finally, we review the existing basic and clinical science literature linking adiposity to ILD, highlighting the need for additional research on the mechanisms of adipocyte-mediated inflammation in ILD and its clinical implications. |
| first_indexed | 2024-03-10T22:56:19Z |
| format | Article |
| id | doaj.art-76e5f07526d54caf9f6b0afc7475a6b7 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T22:56:19Z |
| publishDate | 2023-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-76e5f07526d54caf9f6b0afc7475a6b72023-11-19T09:58:47ZengMDPI AGCells2073-44092023-09-011218220610.3390/cells12182206Linking Adiposity to Interstitial Lung Disease: The Role of the Dysfunctional Adipocyte and InflammationMichael Macklin0Chelsea Thompson1Leticia Kawano-Dourado2Iazsmin Bauer Ventura3Camila Weschenfelder4Andrés Trostchansky5Aline Marcadenti6Robert M. Tighe7Section of Rheumatology, The University of Chicago, Chicago, IL 60637, USASection of Rheumatology, The University of Chicago, Chicago, IL 60637, USAHcor Research Institute (IP-Hcor), Hcor, São Paulo 04004-050, BrazilSection of Rheumatology, The University of Chicago, Chicago, IL 60637, USAGraduate Program in Health Sciences (Cardiology), Cardiology Institute, University Foundation of Cardiology (IC/FUC), Porto Alegre 90050-170, BrazilDepartment of Biochemistry and Biomedical Research Center, School of Medicine, University of the Republic, Montevideo 11800, UruguayHcor Research Institute (IP-Hcor), Hcor, São Paulo 04004-050, BrazilDivision of Pulmonary, Allergy, and Critical Care Medicine, Duke University Medical Center, Durham, NC 27710, USAAdipose tissue has functions beyond its principal functions in energy storage, including endocrine and immune functions. When faced with a surplus of energy, the functions of adipose tissue expand by mechanisms that can be both adaptive and detrimental. These detrimental adipose tissue functions can alter normal hormonal signaling and promote local and systemic inflammation with wide-ranging consequences. Although the mechanisms by which adipose tissue triggers metabolic dysfunction and local inflammation have been well described, little is known about the relationship between adiposity and the pathogenesis of chronic lung conditions, such as interstitial lung disease (ILD). In this review, we detail the conditions and mechanisms by which adipose tissue becomes dysfunctional and relate this dysfunction to inflammatory changes observed in various forms of ILD. Finally, we review the existing basic and clinical science literature linking adiposity to ILD, highlighting the need for additional research on the mechanisms of adipocyte-mediated inflammation in ILD and its clinical implications.https://www.mdpi.com/2073-4409/12/18/2206obesityadiposityinterstitial lung diseaseautoimmunityfibrosisinflammation |
| spellingShingle | Michael Macklin Chelsea Thompson Leticia Kawano-Dourado Iazsmin Bauer Ventura Camila Weschenfelder Andrés Trostchansky Aline Marcadenti Robert M. Tighe Linking Adiposity to Interstitial Lung Disease: The Role of the Dysfunctional Adipocyte and Inflammation Cells obesity adiposity interstitial lung disease autoimmunity fibrosis inflammation |
| title | Linking Adiposity to Interstitial Lung Disease: The Role of the Dysfunctional Adipocyte and Inflammation |
| title_full | Linking Adiposity to Interstitial Lung Disease: The Role of the Dysfunctional Adipocyte and Inflammation |
| title_fullStr | Linking Adiposity to Interstitial Lung Disease: The Role of the Dysfunctional Adipocyte and Inflammation |
| title_full_unstemmed | Linking Adiposity to Interstitial Lung Disease: The Role of the Dysfunctional Adipocyte and Inflammation |
| title_short | Linking Adiposity to Interstitial Lung Disease: The Role of the Dysfunctional Adipocyte and Inflammation |
| title_sort | linking adiposity to interstitial lung disease the role of the dysfunctional adipocyte and inflammation |
| topic | obesity adiposity interstitial lung disease autoimmunity fibrosis inflammation |
| url | https://www.mdpi.com/2073-4409/12/18/2206 |
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