Vascular endothelial growth factor (VEGF) gene polymorphism in oral submucous fibrosis subjects - A preliminary study
Background: Oral Submucous Fibrosis is one of the oral potentially malignant disorders presenting with progressive restriction in mouth opening. The condition having a high malignant transformation rate necessitates identification of biomarkers to be employed for early detection of malignant change....
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| Format: | Article |
| Language: | English |
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Manipal College of Medical Sciences, Pokhara
2016-08-01
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| Series: | Asian Journal of Medical Sciences |
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| Online Access: | https://www.nepjol.info/index.php/AJMS/article/view/15064 |
| _version_ | 1818130821077270528 |
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| author | Devishree V Rai |
| author_facet | Devishree V Rai |
| author_sort | Devishree V Rai |
| collection | DOAJ |
| description | Background: Oral Submucous Fibrosis is one of the oral potentially malignant disorders presenting with progressive restriction in mouth opening. The condition having a high malignant transformation rate necessitates identification of biomarkers to be employed for early detection of malignant change. This will influence the prognosis in addition to adding better quality of life to patients.
Aims and Objectives: To relate the association of VEGF -460C/T polymorphism in patients with OSMF and to compare the same among healthy subjects.
Materials and Methods: Thirty patients with Oral submucous fibrosis and 20 controls free from habits and any form of lesions were included in the study. The polymorphism of VEGF gene was detected by polymerase chain reaction-based restriction analysis.
Results: Sixty-four percent of the population in the study was in the age group of 21-40 yrs suggesting the prominence of disease in younger individuals with male predominance. With reference to polymorphism, 6.67% of the subjects from OSMF group showed CT polymorphism and 16.67% showed TT polymorphism. There were no statistically significant differences in the polymorphism between the study group and controls. However the frequency of T allele in the patient group 12 (20%) was greater than that in the control group 1 (2.5%), which was a significant finding. There was no association between the habits, frequency of habits, duration of quid placement, site of quid placement and style of chewing with the nature of polymorphism.
Conclusion: VEGF 460C/T has the potential to be used as a prognostic marker in predicting the malignant transformation of OSMF. |
| first_indexed | 2024-12-11T08:11:07Z |
| format | Article |
| id | doaj.art-76e6de9ffab344a3b672bf16ec9aed1c |
| institution | Directory Open Access Journal |
| issn | 2467-9100 2091-0576 |
| language | English |
| last_indexed | 2024-12-11T08:11:07Z |
| publishDate | 2016-08-01 |
| publisher | Manipal College of Medical Sciences, Pokhara |
| record_format | Article |
| series | Asian Journal of Medical Sciences |
| spelling | doaj.art-76e6de9ffab344a3b672bf16ec9aed1c2022-12-22T01:14:53ZengManipal College of Medical Sciences, PokharaAsian Journal of Medical Sciences2467-91002091-05762016-08-01751016https://doi.org/10.3126/ajms.v7i5.15064Vascular endothelial growth factor (VEGF) gene polymorphism in oral submucous fibrosis subjects - A preliminary studyDevishree V Rai 0Former Postgraduate, Department of Oral Medicine and Radiology, SDM College of Dental Sciences and Hospital, Sattur, DharwadBackground: Oral Submucous Fibrosis is one of the oral potentially malignant disorders presenting with progressive restriction in mouth opening. The condition having a high malignant transformation rate necessitates identification of biomarkers to be employed for early detection of malignant change. This will influence the prognosis in addition to adding better quality of life to patients. Aims and Objectives: To relate the association of VEGF -460C/T polymorphism in patients with OSMF and to compare the same among healthy subjects. Materials and Methods: Thirty patients with Oral submucous fibrosis and 20 controls free from habits and any form of lesions were included in the study. The polymorphism of VEGF gene was detected by polymerase chain reaction-based restriction analysis. Results: Sixty-four percent of the population in the study was in the age group of 21-40 yrs suggesting the prominence of disease in younger individuals with male predominance. With reference to polymorphism, 6.67% of the subjects from OSMF group showed CT polymorphism and 16.67% showed TT polymorphism. There were no statistically significant differences in the polymorphism between the study group and controls. However the frequency of T allele in the patient group 12 (20%) was greater than that in the control group 1 (2.5%), which was a significant finding. There was no association between the habits, frequency of habits, duration of quid placement, site of quid placement and style of chewing with the nature of polymorphism. Conclusion: VEGF 460C/T has the potential to be used as a prognostic marker in predicting the malignant transformation of OSMF.https://www.nepjol.info/index.php/AJMS/article/view/15064vegf gene polymorphismosmforal cancermalignant transformationpolymerase chain reaction |
| spellingShingle | Devishree V Rai Vascular endothelial growth factor (VEGF) gene polymorphism in oral submucous fibrosis subjects - A preliminary study Asian Journal of Medical Sciences vegf gene polymorphism osmf oral cancer malignant transformation polymerase chain reaction |
| title | Vascular endothelial growth factor (VEGF) gene polymorphism in oral submucous fibrosis subjects - A preliminary study |
| title_full | Vascular endothelial growth factor (VEGF) gene polymorphism in oral submucous fibrosis subjects - A preliminary study |
| title_fullStr | Vascular endothelial growth factor (VEGF) gene polymorphism in oral submucous fibrosis subjects - A preliminary study |
| title_full_unstemmed | Vascular endothelial growth factor (VEGF) gene polymorphism in oral submucous fibrosis subjects - A preliminary study |
| title_short | Vascular endothelial growth factor (VEGF) gene polymorphism in oral submucous fibrosis subjects - A preliminary study |
| title_sort | vascular endothelial growth factor vegf gene polymorphism in oral submucous fibrosis subjects a preliminary study |
| topic | vegf gene polymorphism osmf oral cancer malignant transformation polymerase chain reaction |
| url | https://www.nepjol.info/index.php/AJMS/article/view/15064 |
| work_keys_str_mv | AT devishreevrai vascularendothelialgrowthfactorvegfgenepolymorphisminoralsubmucousfibrosissubjectsapreliminarystudy |