Gatekeeping astrocyte identity
New findings cast doubt on whether suppressing the RNA-binding protein PTBP1 can force astrocytes to become dopaminergic neurons.
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
eLife Sciences Publications Ltd
2022-06-01
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| Series: | eLife |
| Subjects: | |
| Online Access: | https://elifesciences.org/articles/80232 |
| _version_ | 1828382295140073472 |
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| author | Alexis Cooper Benedikt Berninger |
| author_facet | Alexis Cooper Benedikt Berninger |
| author_sort | Alexis Cooper |
| collection | DOAJ |
| description | New findings cast doubt on whether suppressing the RNA-binding protein PTBP1 can force astrocytes to become dopaminergic neurons. |
| first_indexed | 2024-12-10T04:29:25Z |
| format | Article |
| id | doaj.art-76e7f9be5f5c4f188174dfdc2ad680fb |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-12-10T04:29:25Z |
| publishDate | 2022-06-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-76e7f9be5f5c4f188174dfdc2ad680fb2022-12-22T02:02:11ZengeLife Sciences Publications LtdeLife2050-084X2022-06-011110.7554/eLife.80232Gatekeeping astrocyte identityAlexis Cooper0https://orcid.org/0000-0002-2182-0046Benedikt Berninger1https://orcid.org/0000-0003-2652-2782Centre for Developmental Neurobiology, King's College London, London, United Kingdom; The Francis Crick Institute, London, United KingdomCentre for Developmental Neurobiology, King's College London, London, United Kingdom; The Francis Crick Institute, London, United Kingdom; University Medical Center of the Johannes Gutenberg University, Mainz, GermanyNew findings cast doubt on whether suppressing the RNA-binding protein PTBP1 can force astrocytes to become dopaminergic neurons.https://elifesciences.org/articles/80232PTBP1astrocyte-to-neuron conversionlineage reprogrammingparkinson's diseasebrain repairastrocyte |
| spellingShingle | Alexis Cooper Benedikt Berninger Gatekeeping astrocyte identity eLife PTBP1 astrocyte-to-neuron conversion lineage reprogramming parkinson's disease brain repair astrocyte |
| title | Gatekeeping astrocyte identity |
| title_full | Gatekeeping astrocyte identity |
| title_fullStr | Gatekeeping astrocyte identity |
| title_full_unstemmed | Gatekeeping astrocyte identity |
| title_short | Gatekeeping astrocyte identity |
| title_sort | gatekeeping astrocyte identity |
| topic | PTBP1 astrocyte-to-neuron conversion lineage reprogramming parkinson's disease brain repair astrocyte |
| url | https://elifesciences.org/articles/80232 |
| work_keys_str_mv | AT alexiscooper gatekeepingastrocyteidentity AT benediktberninger gatekeepingastrocyteidentity |