The Healthy and Diseased Equine Endometrium: A Review of Morphological Features and Molecular Analyses
Mares are seasonally polyestric. The breeding season in spring and summer and the winter anestrus are flanked by transitional periods. Endometrial diseases are a frequent cause of subfertility and have an economic impact on the horse breeding industry. They include different forms of endometrosis, e...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-04-01
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| Series: | Animals |
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| Online Access: | https://www.mdpi.com/2076-2615/10/4/625 |
| _version_ | 1797571403796447232 |
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| author | Sandra Schöniger Heinz-Adolf Schoon |
| author_facet | Sandra Schöniger Heinz-Adolf Schoon |
| author_sort | Sandra Schöniger |
| collection | DOAJ |
| description | Mares are seasonally polyestric. The breeding season in spring and summer and the winter anestrus are flanked by transitional periods. Endometrial diseases are a frequent cause of subfertility and have an economic impact on the horse breeding industry. They include different forms of endometrosis, endometritis, glandular maldifferentiation, and angiosis. Except for suppurative endometritis, these are subclinical and can only be diagnosed by the microscopic examination of an endometrial biopsy. Endometrosis is characterized by periglandular fibrosis and nonsuppurative endometritis by stromal infiltration with lymphocytes and plasma cells. The pathogenesis of endometrosis and nonsuppurative endometritis is still undetermined. Some mares are predisposed to persistent endometritis; this has likely a multifactorial etiology. Glandular differentiation has to be interpreted under consideration of the season. The presence of endometrial diseases is associated with alterations in the expression of several intra- and extracellular molecular markers. Some of them may have potential to be used as diagnostic biomarkers for equine endometrial health and disease. The aim of this review is to provide an overview on pathomorphological findings of equine endometrial diseases, to outline data on analyses of cellular and molecular mechanisms, and to discuss the impact of these data on reproduction and treatment. |
| first_indexed | 2024-03-10T20:40:01Z |
| format | Article |
| id | doaj.art-76e84cf769d54a42be6d063cbb9a5827 |
| institution | Directory Open Access Journal |
| issn | 2076-2615 |
| language | English |
| last_indexed | 2024-03-10T20:40:01Z |
| publishDate | 2020-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Animals |
| spelling | doaj.art-76e84cf769d54a42be6d063cbb9a58272023-11-19T20:46:10ZengMDPI AGAnimals2076-26152020-04-0110462510.3390/ani10040625The Healthy and Diseased Equine Endometrium: A Review of Morphological Features and Molecular AnalysesSandra Schöniger0Heinz-Adolf Schoon1Targos Molecular Pathology GmbH, Germaniastrasse 7, 34119 Kassel, GermanyInstitute of Veterinary Pathology, Faculty of Veterinary Medicine, Leipzig University, An den Tierkliniken 33, 04103 Leipzig, GermanyMares are seasonally polyestric. The breeding season in spring and summer and the winter anestrus are flanked by transitional periods. Endometrial diseases are a frequent cause of subfertility and have an economic impact on the horse breeding industry. They include different forms of endometrosis, endometritis, glandular maldifferentiation, and angiosis. Except for suppurative endometritis, these are subclinical and can only be diagnosed by the microscopic examination of an endometrial biopsy. Endometrosis is characterized by periglandular fibrosis and nonsuppurative endometritis by stromal infiltration with lymphocytes and plasma cells. The pathogenesis of endometrosis and nonsuppurative endometritis is still undetermined. Some mares are predisposed to persistent endometritis; this has likely a multifactorial etiology. Glandular differentiation has to be interpreted under consideration of the season. The presence of endometrial diseases is associated with alterations in the expression of several intra- and extracellular molecular markers. Some of them may have potential to be used as diagnostic biomarkers for equine endometrial health and disease. The aim of this review is to provide an overview on pathomorphological findings of equine endometrial diseases, to outline data on analyses of cellular and molecular mechanisms, and to discuss the impact of these data on reproduction and treatment.https://www.mdpi.com/2076-2615/10/4/625biomarkerendometrial diseasesequinemaremolecular mechanismspathology |
| spellingShingle | Sandra Schöniger Heinz-Adolf Schoon The Healthy and Diseased Equine Endometrium: A Review of Morphological Features and Molecular Analyses Animals biomarker endometrial diseases equine mare molecular mechanisms pathology |
| title | The Healthy and Diseased Equine Endometrium: A Review of Morphological Features and Molecular Analyses |
| title_full | The Healthy and Diseased Equine Endometrium: A Review of Morphological Features and Molecular Analyses |
| title_fullStr | The Healthy and Diseased Equine Endometrium: A Review of Morphological Features and Molecular Analyses |
| title_full_unstemmed | The Healthy and Diseased Equine Endometrium: A Review of Morphological Features and Molecular Analyses |
| title_short | The Healthy and Diseased Equine Endometrium: A Review of Morphological Features and Molecular Analyses |
| title_sort | healthy and diseased equine endometrium a review of morphological features and molecular analyses |
| topic | biomarker endometrial diseases equine mare molecular mechanisms pathology |
| url | https://www.mdpi.com/2076-2615/10/4/625 |
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