Experimental Variables that Affect Human Hepatocyte AAV Transduction in Liver Chimeric Mice

Experimental Variables that Affect Human Hepatocyte AAV Transduction in Liver Chimeric Mice

Adeno-associated virus (AAV) vector serotypes vary in their ability to transduce hepatocytes from different species. Chimeric mouse models harboring human hepatocytes have shown translational promise for liver-directed gene therapies. However, many variables that influence human hepatocyte transduct...

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Bibliographic Details
Main Authors: Chenhui Zou, Koen O.A. Vercauteren, Eleftherios Michailidis, Mohammad Kabbani, Irene Zoluthkin, Corrine Quirk, Luis Chiriboga, Mustafa Yazicioglu, Xavier M. Anguela, Philip Meuleman, Katherine A. High, Roland W. Herzog, Ype P. de Jong
Format: Article
Language:English
Published: Elsevier 2020-09-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
humanized mice
AAV
gene therapy
liver
human hepatocytes
donor variability
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050120301200

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