Oxidative Stress and AKT-Associated Angiogenesis in a Zebrafish Model and Its Potential Application for Withanolides
Oxidative stress and the AKT serine/threonine kinase (AKT) signaling pathway are essential regulators in cellular migration, metastasis, and angiogenesis. More than 300 withanolides were discovered from the plant family Solanaceae, exhibiting diverse functions. Notably, the relationship between oxid...
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| Format: | Article |
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MDPI AG
2022-03-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/11/6/961 |
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| author | Jen-Yang Tang Yuan-Bin Cheng Ya-Ting Chuang Kun-Han Yang Fang-Rong Chang Wangta Liu Hsueh-Wei Chang |
| author_facet | Jen-Yang Tang Yuan-Bin Cheng Ya-Ting Chuang Kun-Han Yang Fang-Rong Chang Wangta Liu Hsueh-Wei Chang |
| author_sort | Jen-Yang Tang |
| collection | DOAJ |
| description | Oxidative stress and the AKT serine/threonine kinase (AKT) signaling pathway are essential regulators in cellular migration, metastasis, and angiogenesis. More than 300 withanolides were discovered from the plant family Solanaceae, exhibiting diverse functions. Notably, the relationship between oxidative stress, AKT signaling, and angiogenesis in withanolide treatments lacks comprehensive understanding. Here, we summarize connecting evidence related to oxidative stress, AKT signaling, and angiogenesis in the zebrafish model. A convenient vertebrate model monitored the in vivo effects of developmental and tumor xenograft angiogenesis using zebrafish embryos. The oxidative stress and AKT-signaling-modulating abilities of withanolides were highlighted in cancer treatments, which indicated that further assessments of their angiogenesis-modulating potential are necessary in the future. Moreover, targeting AKT for inhibiting AKT and its AKT signaling shows the potential for anti-migration and anti-angiogenesis purposes for future application to withanolides. This particularly holds for investigating the anti-angiogenetic effects mediated by the oxidative stress and AKT signaling pathways in withanolide-based cancer therapy in the future. |
| first_indexed | 2024-03-09T20:01:01Z |
| format | Article |
| id | doaj.art-76e945add283430dada6edcfd9ead933 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-09T20:01:01Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-76e945add283430dada6edcfd9ead9332023-11-24T00:43:54ZengMDPI AGCells2073-44092022-03-0111696110.3390/cells11060961Oxidative Stress and AKT-Associated Angiogenesis in a Zebrafish Model and Its Potential Application for WithanolidesJen-Yang Tang0Yuan-Bin Cheng1Ya-Ting Chuang2Kun-Han Yang3Fang-Rong Chang4Wangta Liu5Hsueh-Wei Chang6School of Post-Baccalaureate Medicine, Kaohsiung Medical University, Kaohsiung 80708, TaiwanDepartment of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 80424, TaiwanDepartment of Biomedical Science and Environmental Biology, College of Life Science, Kaohsiung Medical University, Kaohsiung 80708, TaiwanGraduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 80708, TaiwanGraduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 80708, TaiwanDepartment of Biotechnology, Kaohsiung Medical University, Kaohsiung 80708, TaiwanDepartment of Biomedical Science and Environmental Biology, College of Life Science, Kaohsiung Medical University, Kaohsiung 80708, TaiwanOxidative stress and the AKT serine/threonine kinase (AKT) signaling pathway are essential regulators in cellular migration, metastasis, and angiogenesis. More than 300 withanolides were discovered from the plant family Solanaceae, exhibiting diverse functions. Notably, the relationship between oxidative stress, AKT signaling, and angiogenesis in withanolide treatments lacks comprehensive understanding. Here, we summarize connecting evidence related to oxidative stress, AKT signaling, and angiogenesis in the zebrafish model. A convenient vertebrate model monitored the in vivo effects of developmental and tumor xenograft angiogenesis using zebrafish embryos. The oxidative stress and AKT-signaling-modulating abilities of withanolides were highlighted in cancer treatments, which indicated that further assessments of their angiogenesis-modulating potential are necessary in the future. Moreover, targeting AKT for inhibiting AKT and its AKT signaling shows the potential for anti-migration and anti-angiogenesis purposes for future application to withanolides. This particularly holds for investigating the anti-angiogenetic effects mediated by the oxidative stress and AKT signaling pathways in withanolide-based cancer therapy in the future.https://www.mdpi.com/2073-4409/11/6/961withanolidesoxidative stressAKTangiogenesiszebrafish |
| spellingShingle | Jen-Yang Tang Yuan-Bin Cheng Ya-Ting Chuang Kun-Han Yang Fang-Rong Chang Wangta Liu Hsueh-Wei Chang Oxidative Stress and AKT-Associated Angiogenesis in a Zebrafish Model and Its Potential Application for Withanolides Cells withanolides oxidative stress AKT angiogenesis zebrafish |
| title | Oxidative Stress and AKT-Associated Angiogenesis in a Zebrafish Model and Its Potential Application for Withanolides |
| title_full | Oxidative Stress and AKT-Associated Angiogenesis in a Zebrafish Model and Its Potential Application for Withanolides |
| title_fullStr | Oxidative Stress and AKT-Associated Angiogenesis in a Zebrafish Model and Its Potential Application for Withanolides |
| title_full_unstemmed | Oxidative Stress and AKT-Associated Angiogenesis in a Zebrafish Model and Its Potential Application for Withanolides |
| title_short | Oxidative Stress and AKT-Associated Angiogenesis in a Zebrafish Model and Its Potential Application for Withanolides |
| title_sort | oxidative stress and akt associated angiogenesis in a zebrafish model and its potential application for withanolides |
| topic | withanolides oxidative stress AKT angiogenesis zebrafish |
| url | https://www.mdpi.com/2073-4409/11/6/961 |
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