Gut Microbiota Dynamics in Relation to Long-COVID-19 Syndrome: Role of Probiotics to Combat Psychiatric Complications
Increasing numbers of patients who recover from COVID-19 report lasting symptoms, such as fatigue, muscle weakness, dementia, and insomnia, known collectively as post-acute COVID syndrome or long COVID. These lasting symptoms have been examined in different studies and found to influence multiple or...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-09-01
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| Series: | Metabolites |
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| Online Access: | https://www.mdpi.com/2218-1989/12/10/912 |
| _version_ | 1797471507972096000 |
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| author | Maha F. Alenazy Haya I. Aljohar Ashwag R. Alruwaili Maha H. Daghestani Mona A. Alonazi Ranyah S. Labban Afaf K. El-Ansary Hanan A. Balto |
| author_facet | Maha F. Alenazy Haya I. Aljohar Ashwag R. Alruwaili Maha H. Daghestani Mona A. Alonazi Ranyah S. Labban Afaf K. El-Ansary Hanan A. Balto |
| author_sort | Maha F. Alenazy |
| collection | DOAJ |
| description | Increasing numbers of patients who recover from COVID-19 report lasting symptoms, such as fatigue, muscle weakness, dementia, and insomnia, known collectively as post-acute COVID syndrome or long COVID. These lasting symptoms have been examined in different studies and found to influence multiple organs, sometimes resulting in life-threating conditions. In this review, these symptoms are discussed in connection to the COVID-19 and long-COVID-19 immune changes, highlighting oral and psychiatric health, as this work focuses on the gut microbiota’s link to long-COVID-19 manifestations in the liver, heart, kidney, brain, and spleen. A model of this is presented to show the biological and clinical implications of gut microbiota in SARS-CoV-2 infection and how they could possibly affect the therapeutic aspects of the disease. Probiotics can support the body’s systems in fighting viral infections. This review focuses on current knowledge about the use of probiotics as adjuvant therapies for COVID-19 patients that might help to prevent long-COVID-19 complications. |
| first_indexed | 2024-03-09T19:49:16Z |
| format | Article |
| id | doaj.art-76e9ae7883bf4eec889486d4edb8a75c |
| institution | Directory Open Access Journal |
| issn | 2218-1989 |
| language | English |
| last_indexed | 2024-03-09T19:49:16Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Metabolites |
| spelling | doaj.art-76e9ae7883bf4eec889486d4edb8a75c2023-11-24T01:15:03ZengMDPI AGMetabolites2218-19892022-09-01121091210.3390/metabo12100912Gut Microbiota Dynamics in Relation to Long-COVID-19 Syndrome: Role of Probiotics to Combat Psychiatric ComplicationsMaha F. Alenazy0Haya I. Aljohar1Ashwag R. Alruwaili2Maha H. Daghestani3Mona A. Alonazi4Ranyah S. Labban5Afaf K. El-Ansary6Hanan A. Balto7Department of Physiology, College of Medicine, King Saud University, Riyadh 11682, Saudi ArabiaDepartment of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh 11495, Saudi ArabiaDepartment of Radiological Sciences, College of Applied Medical Science, King Saud University, Riyadh 11595, Saudi ArabiaDepartment of Zoology, College of Science, King Saud University, Riyadh 11495, Saudi ArabiaDepartment of Biochemistry, College of Science, King Saud University, Riyadh 11495, Saudi ArabiaGeneral Administration of Nutrition, Ministry of Health, Riyadh 11595, Saudi ArabiaSenior Scientist, Central Research Laboratory, Female Campus, King Saud University, Riyadh 11595, Saudi ArabiaDepartment of Restorative Dental Sciences, College of Dentistry, King Saud University, P.O. Box 62645, Riyadh 11595, Saudi ArabiaIncreasing numbers of patients who recover from COVID-19 report lasting symptoms, such as fatigue, muscle weakness, dementia, and insomnia, known collectively as post-acute COVID syndrome or long COVID. These lasting symptoms have been examined in different studies and found to influence multiple organs, sometimes resulting in life-threating conditions. In this review, these symptoms are discussed in connection to the COVID-19 and long-COVID-19 immune changes, highlighting oral and psychiatric health, as this work focuses on the gut microbiota’s link to long-COVID-19 manifestations in the liver, heart, kidney, brain, and spleen. A model of this is presented to show the biological and clinical implications of gut microbiota in SARS-CoV-2 infection and how they could possibly affect the therapeutic aspects of the disease. Probiotics can support the body’s systems in fighting viral infections. This review focuses on current knowledge about the use of probiotics as adjuvant therapies for COVID-19 patients that might help to prevent long-COVID-19 complications.https://www.mdpi.com/2218-1989/12/10/912long COVID-19gut microbiotagut–organ axispsychiatric disordersprobiotics |
| spellingShingle | Maha F. Alenazy Haya I. Aljohar Ashwag R. Alruwaili Maha H. Daghestani Mona A. Alonazi Ranyah S. Labban Afaf K. El-Ansary Hanan A. Balto Gut Microbiota Dynamics in Relation to Long-COVID-19 Syndrome: Role of Probiotics to Combat Psychiatric Complications Metabolites long COVID-19 gut microbiota gut–organ axis psychiatric disorders probiotics |
| title | Gut Microbiota Dynamics in Relation to Long-COVID-19 Syndrome: Role of Probiotics to Combat Psychiatric Complications |
| title_full | Gut Microbiota Dynamics in Relation to Long-COVID-19 Syndrome: Role of Probiotics to Combat Psychiatric Complications |
| title_fullStr | Gut Microbiota Dynamics in Relation to Long-COVID-19 Syndrome: Role of Probiotics to Combat Psychiatric Complications |
| title_full_unstemmed | Gut Microbiota Dynamics in Relation to Long-COVID-19 Syndrome: Role of Probiotics to Combat Psychiatric Complications |
| title_short | Gut Microbiota Dynamics in Relation to Long-COVID-19 Syndrome: Role of Probiotics to Combat Psychiatric Complications |
| title_sort | gut microbiota dynamics in relation to long covid 19 syndrome role of probiotics to combat psychiatric complications |
| topic | long COVID-19 gut microbiota gut–organ axis psychiatric disorders probiotics |
| url | https://www.mdpi.com/2218-1989/12/10/912 |
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