Mitochondrial DNA sequence variation and neurodegeneration
<p>Abstract</p> <p>Mitochondria, the powerhouse of the cell, play a critical role in several metabolic processes and apoptotic pathways. Many lines of evidence suggest that mitochondria have a central role in ageing-related neurodegenerative diseases. Moreover, there is a long hist...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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BMC
2008-09-01
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| Series: | Human Genomics |
| Subjects: | |
| Online Access: | http://www.humgenomics.com/content/3/1/71 |
| _version_ | 1817996817442275328 |
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| author | Mancuso Michelangelo Filosto Massimiliano Orsucci Daniele Siciliano Gabriele |
| author_facet | Mancuso Michelangelo Filosto Massimiliano Orsucci Daniele Siciliano Gabriele |
| author_sort | Mancuso Michelangelo |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Mitochondria, the powerhouse of the cell, play a critical role in several metabolic processes and apoptotic pathways. Many lines of evidence suggest that mitochondria have a central role in ageing-related neurodegenerative diseases. Moreover, there is a long history of investigations on mitochondria aimed at identifying genetic markers relating to ageing and neurodegenerative diseases. In this review, some of the major neurodegenerative disorders are highlighted and the role of mitochondrial haplogroups in the pathogenetic cascade leading to these diseases is discussed.</p> |
| first_indexed | 2024-04-14T02:27:52Z |
| format | Article |
| id | doaj.art-76ebc01ecc694a0cbaeaa823e715f659 |
| institution | Directory Open Access Journal |
| issn | 1479-7364 |
| language | English |
| last_indexed | 2024-04-14T02:27:52Z |
| publishDate | 2008-09-01 |
| publisher | BMC |
| record_format | Article |
| series | Human Genomics |
| spelling | doaj.art-76ebc01ecc694a0cbaeaa823e715f6592022-12-22T02:17:49ZengBMCHuman Genomics1479-73642008-09-0131717810.1186/1479-7364-3-1-71Mitochondrial DNA sequence variation and neurodegenerationMancuso MichelangeloFilosto MassimilianoOrsucci DanieleSiciliano Gabriele<p>Abstract</p> <p>Mitochondria, the powerhouse of the cell, play a critical role in several metabolic processes and apoptotic pathways. Many lines of evidence suggest that mitochondria have a central role in ageing-related neurodegenerative diseases. Moreover, there is a long history of investigations on mitochondria aimed at identifying genetic markers relating to ageing and neurodegenerative diseases. In this review, some of the major neurodegenerative disorders are highlighted and the role of mitochondrial haplogroups in the pathogenetic cascade leading to these diseases is discussed.</p>http://www.humgenomics.com/content/3/1/71mitochondriamtDNAmtDNA haplogroupsneurodegenerative disorders |
| spellingShingle | Mancuso Michelangelo Filosto Massimiliano Orsucci Daniele Siciliano Gabriele Mitochondrial DNA sequence variation and neurodegeneration Human Genomics mitochondria mtDNA mtDNA haplogroups neurodegenerative disorders |
| title | Mitochondrial DNA sequence variation and neurodegeneration |
| title_full | Mitochondrial DNA sequence variation and neurodegeneration |
| title_fullStr | Mitochondrial DNA sequence variation and neurodegeneration |
| title_full_unstemmed | Mitochondrial DNA sequence variation and neurodegeneration |
| title_short | Mitochondrial DNA sequence variation and neurodegeneration |
| title_sort | mitochondrial dna sequence variation and neurodegeneration |
| topic | mitochondria mtDNA mtDNA haplogroups neurodegenerative disorders |
| url | http://www.humgenomics.com/content/3/1/71 |
| work_keys_str_mv | AT mancusomichelangelo mitochondrialdnasequencevariationandneurodegeneration AT filostomassimiliano mitochondrialdnasequencevariationandneurodegeneration AT orsuccidaniele mitochondrialdnasequencevariationandneurodegeneration AT sicilianogabriele mitochondrialdnasequencevariationandneurodegeneration |