| Summary: | Moringa Oleifera (MO) has potential for nutritional and medical applications. We verified whether the administration of MO changed mineral accumulation patterns and mitigative effects of lead poisoning using Sprague–Dawley rats. MO leaves, aqueous leaf extracts, and seeds were administrated to rats in two different concentrations (100 and 600 mg/kg body weight/day) for 3 weeks. Element analysis, biochemical blood tests, oxidative-stress assessment, and blood δ-aminolevulinic acid dehydratase (ALAD) activity assays were performed after euthanasia and dissection. Although apparent changes in element accumulation patterns and biochemical parameters for hepatic and renal function assessments were not observed, lead-induced oxidative stress was significantly mitigated by the administration of MO leaves. The administration of high-dose MO leaves and seeds significantly recovered ALAD activity. Further investigations for potential mitigative effects of MO on lead toxicity and its mechanism are required.
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