Rebamipide Promotes the Regeneration of Aspirin-Induced Small-Intestine Mucosal Injury through Accumulation of β-Catenin.

Rebamipide Promotes the Regeneration of Aspirin-Induced Small-Intestine Mucosal Injury through Accumulation of β-Catenin.

The effect of rebamipide on repairing intestinal mucosal damage induced by nonsteroidal anti-inflammatory drugs and its mechanism remain unclear. In this study, we sought to explore the mechanism whereby rebamipide could promote the regeneration of aspirin-induced intestinal mucosal damage.BALB/c mi...

Full description

Bibliographic Details
Main Authors:	Yu Lai, Wa Zhong, Tao Yu, Zhong-Sheng Xia, Jie-Yao Li, Hui Ouyang, Ti-Dong Shan, Hong-Sheng Yang, Qi-Kui Chen
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2015-01-01
Series:	PLoS ONE
Online Access:	http://europepmc.org/articles/PMC4489841?pdf=render

Similar Items

Retraction: Rebamipide Promotes the Regeneration of Aspirin-Induced Small-Intestine Mucosal Injury through Accumulation of β-Catenin.
by: PLOS ONE Editors
Published: (2024-01-01)

Quiescence Exit of Tert+ Stem Cells by Wnt/β-Catenin Is Indispensable for Intestinal Regeneration
by: Han Na Suh, et al.
Published: (2017-11-01)

Prophylactic Effect of Rebamipide on Aspirin-Induced Gastric Lesions and Disruption of Tight Junctional Protein Zonula Occludens-1 Distribution
by: Takahiro Suzuki, et al.
Published: (2008-01-01)

A multicenter, randomized, double-blind, placebo-controlled trial of high-dose rebamipide treatment for low-dose aspirin-induced moderate-to-severe small intestinal damage.
by: Toshio Watanabe, et al.
Published: (2015-01-01)

Rebamipide: New opportunities of gastroenteroprotection
by: V I Simanenkov, et al.
Published: (2015-12-01)

The role of Wnt/β-catenin signaling in enterocyte turnover during methotrexate-induced intestinal mucositis in a rat.
by: Igor Sukhotnik, et al.
Published: (2014-01-01)

Hydrogel Formulations Incorporating Drug Nanocrystals Enhance the Therapeutic Effect of Rebamipide in a Hamster Model for Oral Mucositis
by: Noriaki Nagai, et al.
Published: (2020-06-01)

Preventive Effect of Rebamipide Gargle on Chemoradiotherpy-Induced Oral Mucositis in Patients with Oral Cancer: a Pilot Study
by: Takashi Yasuda, et al.
Published: (2011-11-01)

Rebamipide: evidence base for use in gastroenterology
by: D. N. Andreev, et al.
Published: (2020-12-01)

Pharmacological and clinical feature of rebamipide: new therapeutic targets
by: M. Yu. Zvyaglova, et al.
Published: (2020-02-01)

Regeneration Process Markers in Hyperregenerative Type of Small Intestinal Mucosal Atrophy
by: T. A. Kuznetsova, et al.
Published: (2015-11-01)

The effects of rebamipide, sucralfate, and rifaximin against inflammation and apoptosis in radiation-induced murine intestinal injury
by: Won Moon, et al.
Published: (2022-12-01)

Altered β-catenin expression in oral mucosal dysplasia: a comparative study
by: Brunno Santos de Freitas SILVA, et al.
Published: (2015-10-01)

Rebamipide using in gastroesophageal reflux disease treatment
by: V. T. Ivashkin, et al.
Published: (2020-04-01)

Topical rebamipide improves lid wiper epitheliopathy
by: Itakura H, et al.
Published: (2013-10-01)

Efficacy and Safety of Rebamipide in Prevention of NSAID-Gastropathy
by: Serhiy Tkach, et al.
Published: (2017-03-01)

Enhanced bioavailability of rebamipide nanocrystal tablets: Formulation and in vitro/in vivo evaluation
by: Yu Guo, et al.
Published: (2015-06-01)

Rebamipide ameliorates indomethacin-induced small intestinal damage and proton pump inhibitor-induced exacerbation of this damage by modulation of small intestinal microbiota.
by: Tetsuya Tanigawa, et al.
Published: (2021-01-01)

REBAMIPIDE: EFFECTIVE DRUG PREVENTION OF NSAID ENTEROPATHY IS POSSIBLE
by: E. V. Moroz, et al.
Published: (2016-12-01)

Rebamipide ameliorates atherosclerosis by controlling lipid metabolism and inflammation.
by: JooYeon Jhun, et al.
Published: (2017-01-01)

Topical rebamipide improves the ocular surface in mild lagophthalmos
by: Itakura M, et al.
Published: (2013-07-01)

Preparation and characterization of a novel aspirin derivative with anti-thrombotic and gastric mucosal protection properties.
by: Xi-E Zhen, et al.
Published: (2014-01-01)

The effectiveness of rebamipide mouthwash therapy for radiotherapy and chemoradiotherapy-induced oral mucositis in patients with head and neck cancer: a systematic review and meta-analysis
by: Shinsuke Akagi, et al.
Published: (2019-07-01)

β-Catenin signaling in hepatocellular carcinoma
by: Chuanrui Xu, et al.
Published: (2022-02-01)

Effects of Rebamipide on Gastrointestinal Symptoms in Patients with Type 2 Diabetes Mellitus
by: Sejeong Park, et al.
Published: (2016-04-01)

Wnt/β-Catenin Signaling Activation beyond Robust Nuclear β-Catenin Accumulation in Nondysplastic Barrett’s Esophagus: Regulation via Dickkopf-1
by: Orestis Lyros, et al.
Published: (2015-07-01)

Parkin deficiency prevents chronic ethanol-induced hepatic lipid accumulation through β-catenin accumulation
by: Dong Hun Lee, et al.
Published: (2019-08-01)

Effect of infliximab combination therapy on inflammatory biomarkers and intestinal mucosal healing in patients with extensive Crohn’s disease
by: Jian Jiafu, Liu Sixue, Wu Huibo, Zhong Wa, Xia Zhongsheng, Zhong Yingqiang
Published: (2022-03-01)

High Concentration of Aspirin Induces Apoptosis in Rat Tendon Stem Cells via Inhibition of the Wnt/β-Catenin Pathway
by: Yunjiao Wang, et al.
Published: (2018-11-01)

Glycerol may reduce intestinal mucosal barrier damage in sepsis mice through aquaporin 3
by: HE Rui, ZHU Ye-ke, TENG Wen-bin, SHAN Yue, YI Sheng-hua, ZHU Sheng-mei, LI Yu-hong
Published: (2020-05-01)

Volumetric Compression Induces Intracellular Crowding to Control Intestinal Organoid Growth via Wnt/β-Catenin Signaling
by: Li, Yiwei, et al.
Published: (2022)

Naked1 antagonizes Wnt signaling by preventing nuclear accumulation of β-catenin.
by: Terence J Van Raay, et al.
Published: (2011-04-01)

Pharmacokinetics and pharmacodynamics of rebamipide. New possibilities of therapy: A review
by: Natalia V. Bakulina, et al.
Published: (2023-01-01)

Efficacy of rebamipide 2% ophthalmic solution in the treatment of dry eyes
by: Saurabh Shrivastava, et al.
Published: (2018-01-01)

Resolution of persistent corneal erosion after administration of topical rebamipide
by: Kashima T, et al.
Published: (2012-08-01)

Rebamipide delivered by brushite cement enhances osteoblast and macrophage proliferation.
by: Michael Pujari-Palmer, et al.
Published: (2015-01-01)

Data on chemical activation of Wnt/β-catenin during axolotl limb regeneration
by: Sabina Wischin, et al.
Published: (2017-04-01)

Wnt/β-Catenin Signaling Triggers Neuron Reprogramming and Regeneration in the Mouse Retina
by: Daniela Sanges, et al.
Published: (2013-07-01)

Intracellular Control of β-Catenin and Intestinal Cell Fate by SIRT2
by: Mark R. Frey, PhD
Published: (2020-01-01)

TLR4 activates the β-catenin pathway to cause intestinal neoplasia.
by: Rebeca Santaolalla, et al.
Published: (2013-01-01)