Adjuvant role of macrophages in stem cell-induced cardiac repair in rats
Heart attacks: mixed cell therapy for heart regeneration A tailored technique involving stem cells and anti-inflammatory immune cells shows promise for repairing heart tissue damage. Immune cells called anti-inflammatory macrophages are vital for healing of the heart following a heart attack. Youngk...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2018-11-01
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| Series: | Experimental and Molecular Medicine |
| Online Access: | https://doi.org/10.1038/s12276-018-0171-5 |
| _version_ | 1818608889736724480 |
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| author | Soo yeon Lim Dong Im Cho Hye-yun Jeong Hye-jin Kang Mi Ra Kim Meeyoung Cho Yong Sook Kim Youngkeun Ahn |
| author_facet | Soo yeon Lim Dong Im Cho Hye-yun Jeong Hye-jin Kang Mi Ra Kim Meeyoung Cho Yong Sook Kim Youngkeun Ahn |
| author_sort | Soo yeon Lim |
| collection | DOAJ |
| description | Heart attacks: mixed cell therapy for heart regeneration A tailored technique involving stem cells and anti-inflammatory immune cells shows promise for repairing heart tissue damage. Immune cells called anti-inflammatory macrophages are vital for healing of the heart following a heart attack. Youngkeun Ahn, Yong Sook Kim and co-workers at Chonnam National University Hospital in Gwangju, South Korea trialed a novel stem cell therapy on rats to improve cardiac repair. They took bone marrow-derived macrophages and stem cells from each rat and incubated the two cell types together to create individualized treatments. Following induced heart attacks, they injected one group of rats with both cell types, and another group with stem cells only. While heart function improved in both groups, the group treated with both cell types showed significant improvements with a greater reduction in cardiac fibrosis and increased the reparative activity of macrophages. |
| first_indexed | 2024-12-16T14:49:49Z |
| format | Article |
| id | doaj.art-76ee4a9aae8c476db127bacb6b16cc33 |
| institution | Directory Open Access Journal |
| issn | 1226-3613 2092-6413 |
| language | English |
| last_indexed | 2024-12-16T14:49:49Z |
| publishDate | 2018-11-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Experimental and Molecular Medicine |
| spelling | doaj.art-76ee4a9aae8c476db127bacb6b16cc332022-12-21T22:27:38ZengNature Publishing GroupExperimental and Molecular Medicine1226-36132092-64132018-11-01501111010.1038/s12276-018-0171-5Adjuvant role of macrophages in stem cell-induced cardiac repair in ratsSoo yeon Lim0Dong Im Cho1Hye-yun Jeong2Hye-jin Kang3Mi Ra Kim4Meeyoung Cho5Yong Sook Kim6Youngkeun Ahn7Cell Regeneration Research Center, Chonnam National University HospitalCell Regeneration Research Center, Chonnam National University HospitalCell Regeneration Research Center, Chonnam National University HospitalCell Regeneration Research Center, Chonnam National University HospitalCell Regeneration Research Center, Chonnam National University HospitalCell Regeneration Research Center, Chonnam National University HospitalCell Regeneration Research Center, Chonnam National University HospitalCell Regeneration Research Center, Chonnam National University HospitalHeart attacks: mixed cell therapy for heart regeneration A tailored technique involving stem cells and anti-inflammatory immune cells shows promise for repairing heart tissue damage. Immune cells called anti-inflammatory macrophages are vital for healing of the heart following a heart attack. Youngkeun Ahn, Yong Sook Kim and co-workers at Chonnam National University Hospital in Gwangju, South Korea trialed a novel stem cell therapy on rats to improve cardiac repair. They took bone marrow-derived macrophages and stem cells from each rat and incubated the two cell types together to create individualized treatments. Following induced heart attacks, they injected one group of rats with both cell types, and another group with stem cells only. While heart function improved in both groups, the group treated with both cell types showed significant improvements with a greater reduction in cardiac fibrosis and increased the reparative activity of macrophages.https://doi.org/10.1038/s12276-018-0171-5 |
| spellingShingle | Soo yeon Lim Dong Im Cho Hye-yun Jeong Hye-jin Kang Mi Ra Kim Meeyoung Cho Yong Sook Kim Youngkeun Ahn Adjuvant role of macrophages in stem cell-induced cardiac repair in rats Experimental and Molecular Medicine |
| title | Adjuvant role of macrophages in stem cell-induced cardiac repair in rats |
| title_full | Adjuvant role of macrophages in stem cell-induced cardiac repair in rats |
| title_fullStr | Adjuvant role of macrophages in stem cell-induced cardiac repair in rats |
| title_full_unstemmed | Adjuvant role of macrophages in stem cell-induced cardiac repair in rats |
| title_short | Adjuvant role of macrophages in stem cell-induced cardiac repair in rats |
| title_sort | adjuvant role of macrophages in stem cell induced cardiac repair in rats |
| url | https://doi.org/10.1038/s12276-018-0171-5 |
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